日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Sequential structural rearrangements at the PAM-distal site of a type I-F3 CRISPR-Cas effector enabling RNA-guided DNA transposition

I型F3 CRISPR-Cas效应蛋白PAM远端位点的序列结构重排可实现RNA引导的DNA转座

期刊:Nucleic Acids Research
影响因子:13.1
doi:10.1093/nar/gkaf1415
Ishihara, Kazuki; Matsumoto, Shunsuke; Gerle, Christoph; Gopalasingam, Chai C; Shigematsu, Hideki; Shirai, Tsuyoshi; Numata, Tomoyuki
发表日期：2026
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Structural basis of Neisseria meningitidis quinol dependent nitric oxide reductase activation by dimerization

脑膜炎奈瑟菌醌依赖性一氧化氮还原酶二聚化激活的结构基础

期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-026-09754-0
Gopalasingam, Chai C; Egami, Haruka; Shigematsu, Hideki; Sakaue, Masatora; Fukumoto, Kouki; Gerle, Christoph; Yamamoto, Masaki; Shiro, Yoshitsugu; Muramoto, Kazumasa; Tosha, Takehiko
神经科学
发表日期：2026
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Substrate specificity and action mechanism of the HerA-NurA nuclease from the hyperthermophilic archaeon Thermococcus kodakarensis

来自嗜热古菌科达卡氏热球菌（Thermococcus kodakarensis）的HerA-NurA核酸酶的底物特异性和作用机制

期刊:mBio
影响因子:4.7
doi:10.1128/mbio.03523-25
Uda, Keishiro; Yamagami, Takeshi; Ishino, Sonoko; Gerle, Christoph; Gopalasingam, Chai C; Shigematsu, Hideki; Numata, Tomoyuki; Ishino, Yoshizumi
发表日期：2026
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Cryo-EM structure of the ATP11C Q79E mutant reveals the structural basis for altered Phospholipid recognition

ATP11C Q79E突变体的冷冻电镜结构揭示了磷脂识别改变的结构基础

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.110935
Qian, Yuheng; Gopalasingam, Chai C; Gerle, Christoph; Shigematsu, Hideki; Abe, Kazuhiro; Oshima, Atsunori
发表日期：2026
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Antimicrobial Peptide-Peptoid Macrocycles from the Polymyxin B2 Chemical Space

来自多粘菌素B2化学空间的抗菌肽-类肽大环化合物

期刊:Angewandte Chemie-International Edition
影响因子:16.9
doi:10.1002/anie.202501299
Bonvin, Etienne; Orsi, Markus; Paschoud, Thierry; Gopalasingam, Ashvin; Reusser, Jérémie; Köhler, Thilo; van Delden, Christian; Reymond, Jean-Louis
发表日期：2025
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Lactate infusion improves cardiac function in a porcine model of ischemic cardiogenic shock

乳酸输注可改善猪缺血性心源性休克模型的心脏功能

期刊:Critical Care
影响因子:9.3
doi:10.1186/s13054-025-05346-2
Hørsdal, Oskar Kjærgaard; Ellegaard, Mark Stoltenberg; Larsen, Alexander Møller; Guldbrandsen, Halvor; Moeslund, Niels; Møller, Jacob Eifer; Helgestad, Ole Kristian Lerche; Ravn, Hanne Berg; Wiggers, Henrik; Nielsen, Roni; Gopalasingam, Nigopan; Berg-Hansen, Kristoffer
发表日期：2025
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The ketone body 3-hydroxybutyrate increases cardiac output and cardiac contractility in a porcine model of cardiogenic shock: a randomized, blinded, crossover trial

酮体3-羟基丁酸可增加猪心源性休克模型的心输出量和心肌收缩力：一项随机、双盲、交叉试验

期刊:Basic Research in Cardiology
影响因子:8
doi:10.1007/s00395-025-01103-2
Hørsdal, Oskar Kjærgaard; Larsen, Alexander Møller; Wethelund, Kasper Lykke; Dalsgaard, Frederik Flyvholm; Seefeldt, Jacob Marthinsen; Helgestad, Ole Kristian Lerche; Moeslund, Niels; Møller, Jacob Eifer; Ravn, Hanne Berg; Nielsen, Roni Ranghøj; Wiggers, Henrik; Berg-Hansen, Kristoffer; Gopalasingam, Nigopan
发表日期：2025
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Cardiovascular and Metabolic Effects of Modulating Circulating Ketone Bodies With 1,3-Butanediol in Patients With Heart Failure With Reduced Ejection Fraction

1,3-丁二醇调节循环酮体对射血分数降低的心力衰竭患者心血管和代谢的影响

期刊:Journal of the American Heart Association
影响因子:5.3
doi:10.1161/JAHA.124.038461
Guldbrandsen, Halvor; Gopalasingam, Nigopan; Christensen, Kristian Hylleberg; Hørsdal, Oskar Kjærgaard; Nielsen, Roni; Wiggers, Henrik; Berg-Hansen, Kristoffer
心力衰竭
心血管
代谢
发表日期：2025
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A unique gating mechanism revealed by the cryo-EM structure of monomeric ATP9A flippase

单体ATP9A翻转酶的冷冻电镜结构揭示了一种独特的门控机制

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.110631
Abe, Kazuhiro; Marimuthu, Parthiban; Qian, Yuheng; Gopalasingam, Chai C; Gerle, Christoph; Shigematsu, Hideki; Tanaka, Kotaro; Khandelia, Himanshu
发表日期：2025
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Ketone bodies for hemodynamic support in acute pulmonary embolism: a randomized, blinded, controlled animal study

酮体用于急性肺栓塞血流动力学支持：一项随机、双盲、对照动物研究

期刊:Intensive Care Medicine Experimental
影响因子:3.1
doi:10.1186/s40635-025-00844-7
Lyhne, Mads Dam; Gopalasingam, Nigopan; Berg-Hansen, Kristoffer; Dragsbaek, Simone Juel; Homilius, Casper; Seefeldt, Jacob; Hansen, Jacob Valentin; Kramer, Anders Dahl; Christensen, Lasse Juul; Ellegaard, Mark Stoltenberg; Hørsdal, Oskar Kjærgaard; Overgaard, Andreas; Larsen, Alexander Møller; Boedtkjer, Ebbe; Andersen, Asger; Nielsen, Roni
发表日期：2025
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