日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer's disease models

Corynoxine 可促进 TFEB/TFE3 介导的自噬,并减轻阿尔茨海默病模型中的 Aβ 病理。

Xin-Jie Guan ,Zhi-Qiang Deng ,Jia Liu ,Cheng-Fu Su ,Benjamin Chun-Kit Tong ,Zhou Zhu ,Sravan Gopalkrishnashetty Sreenivasmurthy ,Yu-Xuan Kan ,Ke-Jia Lu ,Carol Pui-Kei Chu ,Rong-Biao Pi ,King-Ho Cheung ,Ashok Iyaswamy ,Ju-Xian Song ,Min Li

F2,6BP restores mitochondrial genome integrity in Huntington's Disease

F2,6BP 恢复亨廷顿氏病中的线粒体基因组完整性

Anirban Chakraborty, Santi M Mandal, Mikita Mankevich, Sravan Gopalkrishnashetty Sreenivasmurthy, Muralidhar L Hegde, Balaji Krishnan, Gourisankar Ghosh, Tapas Hazra

Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease

果糖-2,6-双磷酸恢复 PNKP 的 DNA 修复活性并改善亨廷顿氏病的神经退行性症状

Anirban Chakraborty, Sravan Gopalkrishnashetty Sreenivasmurthy, Wyatt Miller, Weihan Huai, Tapan Biswas, Santi Mohan Mandal, Lisardo Boscá, Balaji Krishnan, Gourisankar Ghosh, Tapas Hazra

Interaction of Tau with Kinesin-1: Effect of Kinesin-1 Heavy Chain Elimination on Autophagy-Mediated Mutant Tau Degradation

Tau 与驱动蛋白-1 的相互作用:驱动蛋白-1 重链消除对自噬介导的突变 Tau 降解的影响

Karthikeyan Selvarasu, Abhay Kumar Singh, Avinash Dakshinamoorthy, Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Moorthi Radhakrishnan, Supriti Patnaik, Jian-Dong Huang, Leonard L Williams, Sanjib Senapati, Siva Sundara Kumar Durairajan

Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

溶酶体 TPCN(双孔段通道)抑制可改善 β-淀粉样蛋白病理并减轻阿尔茨海默病的记忆障碍

Benjamin Chun-Kit Tong, Aston Jiaxi Wu, Alexis Shiying Huang, Rui Dong, Sandeep Malampati, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Chengfu Su, Jia Liu, Juxian Song, Jia-Hong Lu, Jieqiong Tan, Weidong Pan, Min Li, King-Ho Cheung

Tetrandrine ameliorates cognitive deficits and mitigates tau aggregation in cell and animal models of tauopathies

粉防己碱可改善认知缺陷并减轻 tau 蛋白病细胞和动物模型中的 tau 聚集

Benjamin Chun-Kit Tong #, Alexis Shiying Huang #, Aston Jiaxi Wu, Ashok Iyaswamy, Olivia Ka-Yi Ho, Anna Hau-Yee Kong, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, Chengfu Su, Jia Liu, Juxian Song, Min Li, King-Ho Cheung

Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy

Corynoxine B 衍生物 CB6 通过诱导 PIK3C3 复合物依赖性自噬预防小鼠帕金森病毒性

Zhou Zhu, Liang-Feng Liu, Cheng-Fu Su, Jia Liu, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Xin-Jie Guan, Yu-Xuan Kan, Wen-Jian Xie, Chen-Liang Zhao, King-Ho Cheung, Jia-Hong Lu, Jie-Qiong Tan, Hong-Jie Zhang, Ju-Xian Song, Min Li

TFEB, a master regulator of autophagy and biogenesis, unexpectedly promotes apoptosis in response to the cyclopentenone prostaglandin 15d-PGJ2

TFEB 是自噬和生物合成的主要调节器,它意外地促进了环戊烯酮前列腺素 15d-PGJ2 引起的细胞凋亡

Chuan-Bin Yang #, Jia Liu #, Benjamin Chun-Kit Tong, Zi-Ying Wang, Zhou Zhu, Cheng-Fu Su, Sravan Gopalkrishnashetty Sreenivasmurthy, Jia-Xi Wu, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Shi-Ying Huang, King-Ho Cheung, Ju-Xian Song, Jie-Qiong Tan, Jia-Hong Lu, Min Li

Reduction of kinesin I heavy chain decreases tau hyperphosphorylation, aggregation, and memory impairment in Alzheimer's disease and tauopathy models

驱动蛋白 I 重链的减少可降低阿尔茨海默病和 tau 蛋白病模型中的 tau 过度磷酸化、聚集和记忆障碍

Karthikeyan Selvarasu, Abhay Kumar Singh, Ashok Iyaswamy, Sravan Gopalkrishnashetty Sreenivasmurthy, Senthilkumar Krishnamoorthi, Amal Kanti Bera, Jian-Dong Huang, Siva Sundara Kumar Durairajan

Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer's disease therapy

溴代原阿片是一种新型原阿片衍生物,可通过激活分子伴侣介导的自噬来缓解 tau 病理,从而治疗阿尔茨海默病

Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Rambabu N Reddi, Ananth Kumar Kammala, Karthick Vasudevan, Sanjib Senapati, Zhou Zhu, Cheng-Fu Su, Jia Liu, Xin-Jie Guan, Ka-Kit Chua, King-Ho Cheung, Hubiao Chen, Hong-Jie Zhang, Yuan Zhang, Ju-Xian Song, Siva S