文献库，生知库 | 链接生命科学的每一步

James Larkin, Richard Marais, Nuria Porta, David Gonzalez de Castro, Lisa Parsons, Christina Messiou, Gordon Stamp, Lisa Thompson, Kim Edmonds, Sarah Sarker, Jane Banerji, Paul Lorigan, Thomas R Jeffry Evans, Pippa Corrie, Ernest Marshall, Mark R Middleton, Paul Nathan, Steve Nicholson, Christian Ot

肿瘤

黑色素瘤

发表日期：2024

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Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

ALC1 核小体重塑缺陷导致 PARPi 敏感化，并与 HRD 产生合成致死性。

期刊:Molecular Cell

影响因子:14.5

doi:10.1016/j.molcel.2020.12.006

Graeme Hewitt ,Valerie Borel ,Sandra Segura-Bayona ,Tohru Takaki ,Phil Ruis ,Roberto Bellelli ,Laura C Lehmann ,Lucia Sommerova ,Aleksandra Vancevska ,Antonia Tomas-Loba ,Kang Zhu ,Christopher Cooper ,Kasper Fugger ,Harshil Patel ,Robert Goldstone ,Deborah Schneider-Luftman ,Ellie Herbert ,Gordon Stamp ,Rachel Brough ,Stephen Pettitt ,Christopher J Lord ,Stephen C West ,Ivan Ahel ,Dragana Ahel ,J Ross Chapman ,Sebastian Deindl ,Simon J Boulton

PARP

发表日期：2021

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RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance

RAC1P29S通过血清反应因子诱导间质表型转换，促进黑色素瘤发展和治疗耐药性。

期刊:Cancer Cell

影响因子:48.8

doi:10.1016/j.ccell.2019.05.015

Daniël A Lionarons,David C Hancock,Sareena Rana,Philip East,Christopher Moore,Miguel M Murillo,Joana Carvalho,Bradley Spencer-Dene,Eleanor Herbert,Gordon Stamp,Djamil Damry,Dinis P Calado,Ian Rosewell,Ralph Fritsch,Richard R Neubig,Miriam Molina-Arcas,Julian Downward

Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis

Polε不稳定导致复制压力、发育异常和肿瘤发生

期刊:Molecular Cell

影响因子:14.5

doi:10.1016/j.molcel.2018.04.008

Roberto Bellelli ，Valerie Borel ，Clare Logan ，Jennifer Svendsen ，Danielle E Cox ，Emma Nye ，Kay Metcalfe ，Susan M O'Connell ，Gordon Stamp ，Helen R Flynn ，Ambrosius P Snijders ，François Lassailly ，Andrew Jackson ，Simon J Boulton

Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer

RAS 与 PI 3-激酶相互作用的破坏可诱导 EGFR 突变驱动的肺癌消退

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2018.12.003

Miguel M Murillo, Sareena Rana, Bradley Spencer-Dene, Emma Nye, Gordon Stamp, Julian Downward

YAP drives cutaneous squamous cell carcinoma formation and progression

YAP 促进皮肤鳞状细胞癌的形成和进展

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.33304

Zoé Vincent-Mistiaen #, Ahmed Elbediwy #, Hannah Vanyai, Jennifer Cotton, Gordon Stamp, Emma Nye, Bradley Spencer-Dene, Gareth J Thomas, Junhao Mao, Barry Thompson

Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression

导管来源和腺泡来源的胰腺导管腺癌表现出不同的肿瘤进展和标志物表达

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2017.09.093

Rute M M Ferreira ,Rocio Sancho ,Hendrik A Messal ,Emma Nye ,Bradley Spencer-Dene ,Richard K Stone ,Gordon Stamp ,Ian Rosewell ,Alberto Quaglia ,Axel Behrens

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling

YAP1 和 TAZ 通过直接上调 JAK-STAT3 信号来控制小鼠胰腺癌的发生

期刊:Gastroenterology

影响因子:25.7

doi:10.1053/j.gastro.2016.05.006

Ralph Gruber, Richard Panayiotou, Emma Nye, Bradley Spencer-Dene, Gordon Stamp, Axel Behrens

Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours

Lgr6 标记了一类稀有的乳腺祖细胞，这些细胞能够形成乳腺腔内肿瘤

期刊:Nature Cell Biology

影响因子:17.3

doi:10.1038/ncb3434

Leander Blaas, Fabio Pucci, Hendrik A Messal, Agneta B Andersson, E Josue Ruiz, Marco Gerling, Iyadh Douagi, Bradley Spencer-Dene, Alexandra Musch, Richard Mitter, Leena Bhaw, Richard Stone, Dorothee Bornhorst, Abdul K Sesay, Jos Jonkers, Gordon Stamp, Ilaria Malanchi, Rune Toftgård, Axel Behrens

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments

抑制脂肪酸去饱和对代谢受损环境中的癌细胞生存有害

期刊:Cancer & Metabolism

影响因子:6

doi:10.1186/s40170-016-0146-8

Barrie Peck #, Zachary T Schug #, Qifeng Zhang, Beatrice Dankworth, Dylan T Jones, Elizabeth Smethurst, Rachana Patel, Susan Mason, Ming Jiang, Rebecca Saunders, Michael Howell, Richard Mitter, Bradley Spencer-Dene, Gordon Stamp, Lynn McGarry, Daniel James, Emma Shanks, Eric O Aboagye, Susan E Critc

Nilotinib in KIT-driven advanced melanoma: Results from the phase II single-arm NICAM trial

尼洛替尼治疗 KIT 驱动的晚期黑色素瘤：II 期单臂 NICAM 试验结果

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

ALC1 核小体重塑缺陷导致 PARPi 敏感化，并与 HRD 产生合成致死性。

RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance

RAC1P29S通过血清反应因子诱导间质表型转换，促进黑色素瘤发展和治疗耐药性。

Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis

Polε不稳定导致复制压力、发育异常和肿瘤发生

Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer

RAS 与 PI 3-激酶相互作用的破坏可诱导 EGFR 突变驱动的肺癌消退

YAP drives cutaneous squamous cell carcinoma formation and progression

YAP 促进皮肤鳞状细胞癌的形成和进展

Duct- and Acinar-Derived Pancreatic Ductal Adenocarcinomas Show Distinct Tumor Progression and Marker Expression

导管来源和腺泡来源的胰腺导管腺癌表现出不同的肿瘤进展和标志物表达

YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK-STAT3 Signaling

YAP1 和 TAZ 通过直接上调 JAK-STAT3 信号来控制小鼠胰腺癌的发生

Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours

Lgr6 标记了一类稀有的乳腺祖细胞，这些细胞能够形成乳腺腔内肿瘤

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments

抑制脂肪酸去饱和对代谢受损环境中的癌细胞生存有害