日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Disulfiram metabolite Cu(DDC)(2) enhances radionuclide uptake in vivo revealing insights into tumoural ablation resistance

双硫仑代谢物 Cu(DDC)₂ 可增强体内放射性核素的摄取,揭示肿瘤消融耐药机制。

Brookes, Katie; Fear, Jessica S; Thornton, Caitlin E M; Zha, Ling; Kim, Jana; Small, Benjamin; Wongsanit, Sarinya; Nieto, Hannah R; Adcock, Holly; Jones, Adam; Pham, Truc T; Bottegoni, Giovanni; Cox, Liam R; Kannappan, Vinodh; Wang, Weiguang; Gorvin, Caroline M; Stover, Daniel G; Spitzweg, Christine; Jhiang, Sissy; Ringel, Matthew D; Campbell, Moray J; Sunassee, Kavitha; Blower, Philip J; Boelaert, Kristien; Smith, Vicki E; Read, Martin L; McCabe, Christopher J

The role of accessory proteins and co-factors in regulation of melanocortin-4 receptor signalling: An update

辅助蛋白和辅因子在黑皮质素-4受体信号调控中的作用:最新进展

Jamaluddin, Aqfan; McClellan, Alyce; Raffan, Eleanor; Gorvin, Caroline M

Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans

犬类全基因组关联研究发现 DENND1B 是犬类和人类的肥胖基因。

Wallis, Natalie J; McClellan, Alyce; Mörseburg, Alexander; Kentistou, Katherine A; Jamaluddin, Aqfan; Dowsett, Georgina K C; Schofield, Ellen; Morros-Nuevo, Anna; Saeed, Sadia; Lam, Brian Y H; Sumanasekera, Natasha T; Chan, Justine; Kumar, Sambhavi S; Zhang, Rey M; Wainwright, Jodie F; Dittmann, Marie; Lakatos, Gabriella; Rainbow, Kara; Withers, David; Bounds, Rebecca; Ma, Marcella; German, Alexander J; Ladlow, Jane; Sargan, David; Froguel, Philippe; Farooqi, I Sadaf; Ong, Ken K; Yeo, Giles S H; Tadross, John A; Perry, John R B; Gorvin, Caroline M; Raffan, Eleanor

Genetic variants predisposing to an increased risk of kidney stone disease.

导致肾结石疾病风险增加的基因变异

Lovegrove Catherine E, Goldsworthy Michelle, Haley Jeremy, Smelser Diane, Gorvin Caroline, Hannan Fadil M, Mahajan Anubha, Suri Mohnish, Sadeghi-Alavijeh Omid, Moochhala Shabbir H, Gale Daniel P, Carey David, Holmes Michael V, Furniss Dominic, Thakker Rajesh V, Howles Sarah A

A calcium-sensing receptor allelic series and underdiagnosis of genetically driven hypocalcemia

钙敏感受体等位基因系列与遗传性低钙血症的漏诊

Chang, Jeremy B; Barnhill, Connor P; Apostolov, Alexander M; Soliai, Marcus M; Hecker, Julian; Nierenberg, Jovia L; Stapleton Smith, Lyndsay M; Mathew, Arun S; Zeng, Xue; Diao, Jiayin; Fernando, C Dilanka; Chen, Qingwen; Dulken, Ben W; Petukhov, Aleksandr; Altman, Russ; Josephs, Tracy M; Lasky-Su, Jessica A; Gorvin, Caroline M; Roberts, Mary Scott; Adler, Scott H; Fox, Jonathan C; Lange, Christoph; Ji, Sun-Gou

The accessory protein MRAP2 directly interacts with melanocortin-3 receptor to enhance signaling.

辅助蛋白 MRAP2 直接与黑皮质素-3 受体相互作用,增强信号传导。

Jamaluddin Aqfan, Wyatt Rachael A, Lee Joon, Dowsett Georgina K C, Tadross John A, Broichhagen Johannes, Yeo Giles S H, Levitz Joshua, Gorvin Caroline M

An activating calcium-sensing receptor variant with biased signaling reveals a critical residue for Gα11 coupling

一种具有偏向性信号传导的激活型钙敏感受体变体揭示了Gα11偶联的关键残基

Benson, Matthew R; Wyatt, Rachael A; Levine, Michael A; Gorvin, Caroline M

A calcium-sensing receptor dileucine motif directs internalization to spatially distinct endosomal signaling pathways

钙敏感受体二亮氨酸基序指导内吞作用进入空间上不同的内体信号通路

Rachael A Wyatt ,Meurig T Gallagher ,Ling Zha ,Christopher J McCabe ,Caroline M Gorvin

Identification of anti-resorptive GPCRs by high-content imaging in human osteoclasts.

利用高内涵成像技术鉴定人破骨细胞中的抗骨吸收GPCR

Price Maria L, Wyatt Rachael A, Correia Joao, Areej Zakia, Hinds Maisie, Crastin Ana, Hardy Rowan S, Frost Morten, Gorvin Caroline M

Obesity-associated MRAP2 variants impair multiple MC4R-mediated signaling pathways

与肥胖相关的MRAP2变异会损害多种MC4R介导的信号通路

Rachael A Wyatt ,Aqfan Jamaluddin ,Vinesh Mistry ,Caitlin Quinn ,Caroline M Gorvin