日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combination p53 activation and BCL-xL/BCL-2 inhibition as a therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia

联合使用 p53 激活和 BCL-xL/BCL-2 抑制作为高风险和复发性急性淋巴细胞白血病的治疗策略

Hayden L Bell, Helen J Blair, Samantha J Jepson Gosling, Martin Galler, Daniel Astley, Anthony V Moorman, Olaf Heidenreich, Gareth J Veal, Frederik W van Delft, John Lunec, Julie A E Irving

Niclosamide does not modulate airway epithelial function through blocking of the calcium activated chloride channel, TMEM16A

尼克酰胺并非通过阻断钙激活氯离子通道TMEM16A来调节气道上皮功能。

Danahay, Henry; Lilley, Sarah; Adley, Kathryn; Charlton, Holly; Fox, Roy; Gosling, Martin

Safety and efficacy of the cystic fibrosis transmembrane conductance regulator potentiator icenticaftor (QBW251)

囊性纤维化跨膜传导调节因子增强剂icenticaftor(QBW251)的安全性和有效性

Kazani, Shamsah; Rowlands, David J; Bottoli, Ivan; Milojevic, Julie; Alcantara, Jose; Jones, Ieuan; Kulmatycki, Kenneth; Machineni, Surendra; Mostovy, Lidia; Nicholls, Ian; Nick, Jerry A; Rowe, Steven M; Simmonds, Nicholas J; Vegesna, Raju; Verheijen, Jeroen; Danahay, Henry; Gosling, Martin; Ayalavajjala, Phaninatha Sarma; Salman, Mohammed; Strieter, Robert

TMEM16A Potentiation: A Novel Therapeutic Approach for the Treatment of Cystic Fibrosis

TMEM16A 增强:一种治疗囊性纤维化的新型治疗方法

Danahay, Henry L; Lilley, Sarah; Fox, Roy; Charlton, Holly; Sabater, Juan; Button, Brian; McCarthy, Clive; Collingwood, Stephen P; Gosling, Martin

Reply to Olschewski et al.: TMEM16A Potentiation: Possible Drawbacks

回复 Olschewski 等人:TMEM16A 增强作用:可能的缺点

Danahay, Henry L; Morris, David G; Gosling, Martin

TMEM16A: An Alternative Approach to Restoring Airway Anion Secretion in Cystic Fibrosis?

TMEM16A:一种恢复囊性纤维化患者气道阴离子分泌的替代方法?

Danahay, Henry; Gosling, Martin

Efficacy and Safety of the CFTR Potentiator Icenticaftor (QBW251) in COPD: Results from a Phase 2 Randomized Trial

CFTR 增强剂 Icenticaftor (QBW251) 治疗 COPD 的疗效和安全性:一项 II 期随机试验的结果

Rowe, Steven M; Jones, Ieuan; Dransfield, Mark T; Haque, Nazmul; Gleason, Stephen; Hayes, Katy A; Kulmatycki, Kenneth; Yates, Denise P; Danahay, Henry; Gosling, Martin; Rowlands, David J; Grant, Sarah S

Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction

增强TMEM16A活性并不会刺激气道黏液分泌或支气管和肺动脉平滑肌收缩。

Danahay, Henry; Fox, Roy; Lilley, Sarah; Charlton, Holly; Adley, Kathryn; Christie, Lee; Ansari, Ejaz; Ehre, Camille; Flen, Alexis; Tuvim, Michael J; Dickey, Burton F; Williams, Colin; Beaudoin, Sarah; Collingwood, Stephen P; Gosling, Martin

Variomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation

变异组学筛选鉴定出钙激活氯离子通道 ANO1 的重入环,该重入环促进通道激活。

Bill, Anke; Popa, M Oana; van Diepen, Michiel T; Gutierrez, Abraham; Lilley, Sarah; Velkova, Maria; Acheson, Kathryn; Choudhury, Hedaythul; Renaud, Nicole A; Auld, Douglas S; Gosling, Martin; Groot-Kormelink, Paul J; Gaither, L Alex

Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease.

抑制肌醇激酶Itpkb可增强淋巴细胞中的钙信号传导,并揭示治疗自身免疫性疾病的新策略

Miller Andrew T, Dahlberg Carol, Sandberg Mark L, Wen Ben G, Beisner Daniel R, Hoerter John A H, Parker Albert, Schmedt Christian, Stinson Monique, Avis Jacqueline, Cienfuegos Cynthia, McPate Mark, Tranter Pamela, Gosling Martin, Groot-Kormelink Paul J, Dawson Janet, Pan Shifeng, Tian Shin-Shay, Seidel H Martin, Cooke Michael P