日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Study protocol for assessment of the efficacy of calcium dobesilate versus placebo on SARS-CoV-2 viral load in outpatients with COVID-19 (CADOVID study): a randomised, placebo-controlled, double-blind, monocentric phase II trial

评估钙多贝西酸盐与安慰剂对门诊COVID-19患者SARS-CoV-2病毒载量疗效的研究方案(CADOVID研究):一项随机、安慰剂对照、双盲、单中心II期试验

Salamun, Julien; Da Silva, Tamara; Ustero, Pilar; Gosmain, Yvan; Guessous, Idris; Calmy, Alexandra; Spechbach, Herve

Sphingosine-1-phosphate as a key player of insulin secretion induced by high-density lipoprotein treatment

鞘氨醇-1-磷酸酯是高密度脂蛋白治疗诱导胰岛素分泌的关键因素

Brulhart-Meynet, Marie-Claude; Thomas, Aurélien; Sidibé, Jonathan; Visentin, Florian; Dusaulcy, Rodolphe; Schwitzgebel, Valérie; Pataky, Zoltan; Philippe, Jacques; Vuilleumier, Nicolas; James, Richard W; Gosmain, Yvan; Frias, Miguel A

miR-132-3p is a positive regulator of alpha-cell mass and is downregulated in obese hyperglycemic mice

miR-132-3p是α细胞数量的正向调节因子,在肥胖高血糖小鼠中表达下调。

Rodolphe Dusaulcy ,Sandra Handgraaf ,Florian Visentin ,Christian Vesin ,Jacques Philippe ,Yvan Gosmain

High-fat diet impacts more changes in beta-cell compared to alpha-cell transcriptome

与α细胞转录组相比,高脂饮食对β细胞转录组的影响更大。

Dusaulcy, Rodolphe; Handgraaf, Sandra; Visentin, Florian; Howald, Cedric; Dermitzakis, Emmanouil T; Philippe, Jacques; Gosmain, Yvan

17-β Estradiol regulates proglucagon-derived peptide secretion in mouse and human α- and L cells

17-β雌二醇调节小鼠和人α细胞和L细胞中胰高血糖素原衍生肽的分泌。

Sandra Handgraaf, Rodolphe Dusaulcy, Florian Visentin, Jacques Philippe, Yvan Gosmain

α-Cell Dysfunctions and Molecular Alterations in Male Insulinopenic Diabetic Mice Are Not Completely Corrected by Insulin

胰岛素缺乏型糖尿病雄性小鼠的α细胞功能障碍和分子改变不能被胰岛素完全纠正

Dusaulcy, Rodolphe; Handgraaf, Sandra; Heddad-Masson, Mounia; Visentin, Florian; Vesin, Christian; Reimann, Franck; Gribble, Fiona; Philippe, Jacques; Gosmain, Yvan

Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia

雄性肥胖小鼠肠内分泌L细胞的功能和分子适应与胰腺α细胞功能的维持和高血糖的预防有关

Dusaulcy, Rodolphe; Handgraaf, Sandra; Skarupelova, Svetlana; Visentin, Florian; Vesin, Christian; Heddad-Masson, Mounia; Reimann, Frank; Gribble, Fiona; Philippe, Jacques; Gosmain, Yvan

Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function

Pax6 控制与胰腺 α 细胞分化和功能有关的关键基因的表达

Yvan Gosmain, Eric Marthinet, Claire Cheyssac, Audrey Guérardel, Aline Mamin, Liora S Katz, Karim Bouzakri, Jacques Philippe

Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2

Pax6 调节胰高血糖素原加工酶 PC2 及其分子伴侣 7B2。

Katz, Liora S; Gosmain, Yvan; Marthinet, Eric; Philippe, Jacques

The beta-cell specific transcription factor Nkx6.1 inhibits glucagon gene transcription by interfering with Pax6

β 细胞特异性转录因子 Nkx6.1 通过干扰 Pax6 来抑制胰高血糖素基因转录

Benoit R Gauthier, Yvan Gosmain, Aline Mamin, Jacques Philippe