日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ICOS is upregulated on T cells following radiation and agonism combined with radiation results in enhanced tumor control.

放射治疗后,T细胞上的ICOS表达上调,激动剂与放射治疗相结合可增强肿瘤控制

Blair Tiffany, Baird Jason, Bambina Shelly, Kramer Gwen, Gostissa Monica, Harvey Christopher J, Gough Michael J, Crittenden Marka R

ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models

JTX-2011(vopratelimab)对ICOS的激动作用需要初始T细胞启动和Fc交联才能在临床前模型中实现最佳的T细胞活化和抗肿瘤免疫。

Amanda Hanson ,Kutlu Elpek ,Ellen Duong ,Lindsey Shallberg ,Martin Fan ,Calvin Johnson ,Matthew Wallace ,George R Mabry ,Stephen Sazinsky ,Lauren Pepper ,Chengyi J Shu ,Sriram Sathyanarayanan ,Sarah Zuerndorfer ,Tyler Simpson ,Monica Gostissa ,Michael Briskin ,Deborah Law ,Jennifer Michaelson ,Christopher J Harvey

Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells

磷脂酰肌醇 3-激酶δ阻断增加 B 细胞的基因组不稳定性

Mara Compagno, Qi Wang, Chiara Pighi, Taek-Chin Cheong, Fei-Long Meng, Teresa Poggio, Leng-Siew Yeap, Elif Karaca, Rafael B Blasco, Fernanda Langellotto, Chiara Ambrogio, Claudia Voena, Adrian Wiestner, Siddha N Kasar, Jennifer R Brown, Jing Sun, Catherine J Wu, Monica Gostissa, Frederick W Alt, Rob

Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells

通过对 CD8 T 细胞进行纵向无创监测来预测对 CTLA-4 阻断的反应

Rashidian, Mohammad; Ingram, Jessica R; Dougan, Michael; Dongre, Anushka; Whang, Katherine A; LeGall, Camille; Cragnolini, Juan J; Bierie, Brian; Gostissa, Monica; Gorman, James; Grotenbreg, Gijsbert M; Bhan, Atul; Weinberg, Robert A; Ploegh, Hidde L

Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching

AID引发的DNA断裂的方向特异性连接促进抗体类别转换

Junchao Dong #, Rohit A Panchakshari #, Tingting Zhang #, Yu Zhang, Jiazhi Hu, Sabrina A Volpi, Robin M Meyers, Yu-Jui Ho, Zhou Du, Davide F Robbiani, Feilong Meng, Monica Gostissa, Michel C Nussenzweig, John P Manis, Frederick W Alt

A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1.

基于胚胎干细胞的快速小鼠模型用于研究由 Epstein-Barr 病毒蛋白 LMP1 驱动的 B 细胞淋巴瘤

Ba Zhaoqing, Meng Fei-Long, Gostissa Monica, Huang Pei-Yi, Ke Qiang, Wang Zhe, Dao Mai N, Fujiwara Yuko, Rajewsky Klaus, Zhang Baochun, Alt Frederick W

IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances.

IgH 类别转换利用了两个 DNA 断裂在较长的染色体距离上以顺式连接这一普遍特性

Gostissa Monica, Schwer Bjoern, Chang Amelia, Dong Junchao, Meyers Robin M, Marecki Gregory T, Choi Vivian W, Chiarle Roberto, Zarrin Ali A, Alt Frederick W

Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice

ATM缺陷小鼠外周B细胞淋巴瘤的促发机制

Tepsuporn, Suprawee; Hu, Jiazhi; Gostissa, Monica; Alt, Frederick W

Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes

V(D)J 重组相关 DNA 断裂和易位通过双着丝粒染色体在成熟 B 细胞中发育传播

Jiazhi Hu, Suprawee Tepsuporn, Robin M Meyers, Monica Gostissa, Frederick W Alt

Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector

切除重编程转基因可提高利用单个可切除载体产生的 iPS 细胞的分化潜能

Cesar A Sommer, Andreia Gianotti Sommer, Tyler A Longmire, Constantina Christodoulou, Dolly D Thomas, Monica Gostissa, Fred W Alt, George J Murphy, Darrell N Kotton, Gustavo Mostoslavsky