日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses.

内源性 p21 水平通过抑制过量和受限的新生 DNA 合成来保护基因组稳定性。

Calzetta Nicolás L, Mansilla Sabrina F, Ahlers Candelaria Mares, Bertolin Agostina P, Caimi Lilen I, Arbilla Sofía Venerus, Zeng Jingkun, Wiesmüller Lisa, Gottifredi Vanesa

Versatile enhancement of the killing potential of anti-cancer agents achieved by peptide mimetics of the PCNA interface towards specialized DNA polymerases.

通过肽模拟物模拟 PCNA 界面与特异性 DNA 聚合酶的相互作用,实现抗癌药物杀伤潜力的多功能增强

Okraine Yiovana Verónica, de la Vega María Belén, Venerus Arbilla Sofía, Moyano Ginette, Bertolin Agostina P, Pallarés Horacio M, Wiesmüller Lisa, Mansilla Sabrina F, Gottifredi Vanesa

The levels of p53 govern the hierarchy of DNA damage tolerance pathway usage

p53 的水平决定了 DNA 损伤耐受通路使用的层级。

Bryan A Castaño ,Sabrina Schorer ,Yitian Guo ,Nicolás L Calzetta ,Vanesa Gottifredi ,Lisa Wiesmüller ,Stephanie Biber

Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability

聚合酶 iota (Pol ι) 可防止 PrimPol 介导的新生 DNA 合成和染色体不稳定性

Sabrina F Mansilla, Agostina P Bertolin, Sofía Venerus Arbilla, Bryan A Castaño, Tiya Jahjah, Jenny K Singh, Sebastián O Siri, María Victoria Castro, María Belén de la Vega, Annabel Quinet, Lisa Wiesmüller, Vanesa Gottifredi

Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells

Rho 激酶 (ROCK) 抑制剂会在 BRCA2 缺陷细胞中诱发多种有丝分裂缺陷和合成致死

Julieta Martino #, Sebastián Omar Siri #, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi

Correction: Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells

更正:Rho激酶(ROCK)抑制剂可诱导BRCA2缺陷细胞出现多种有丝分裂缺陷和合成致死性。

Martino, Julieta; Siri, Sebastián Omar; Calzetta, Nicolás Luis; Paviolo, Natalia Soledad; Garro, Cintia; Pansa, Maria F; Carbajosa, Sofía; Brown, Aaron C; Bocco, José Luis; Gloger, Israel; Drewes, Gerard; Madauss, Kevin P; Soria, Gastón; Gottifredi, Vanesa

Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices

干性特征、p53 和 pol iota 之间的相互作用对复制途径选择的影响

Michaela Ihle, Stephanie Biber, Insa S Schroeder, Christine Blattner, Miriam Deniz, Giovanna Damia, Vanesa Gottifredi, Lisa Wiesmüller

Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance

p53分子的多种生化特性有助于激活依赖于聚合酶ι的DNA损伤耐受机制。

Stephanie Biber ,Helmut Pospiech ,Vanesa Gottifredi ,Lisa Wiesmüller

Mus81-Eme1-dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity

有丝分裂中 Mus81-Eme1 依赖的 DNA 复制中间体的异常加工损害了基因组完整性

Nicolás Luis Calzetta, Marina Alejandra González Besteiro, Vanesa Gottifredi

Under-Replicated DNA: The Byproduct of Large Genomes?

低复制DNA:大型基因组的副产品?

Bertolin, Agustina P; Hoffmann, Jean-Sébastien; Gottifredi, Vanesa