文献库，生知库 | 链接生命科学的每一步

日期影响因子

Cryo-EM of autoantibody-bound NMDA receptors reveals antigenic hotspots in an active immunization model of anti-NMDAR encephalitis

冷冻电镜观察自身抗体结合的NMDA受体，揭示了抗NMDAR脑炎主动免疫模型中的抗原热点。

期刊:Science Advances

影响因子:12.5

doi:10.1126/sciadv.aeb4249

Kim, Junhoe; Jalali-Yazdi, Farzad; Jones, Brian E; Westbrook, Gary L; Gouaux, Eric

免疫/内分泌

发表日期：2026

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Efficient and rapid isolation of native AMPA receptor complexes for cryo-EM

高效快速分离天然AMPA受体复合物用于冷冻电镜分析

期刊:Protein Science

影响因子:5.2

doi:10.1002/pro.70483

Park, Jumi; Gouaux, Eric

发表日期：2026

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Native architecture, allosteric modulation and gating mechanism of glycine-dependent NMDA receptors

甘氨酸依赖性NMDA受体的天然结构、变构调节和门控机制

doi:10.64898/2026.04.13.718261

Kim, Junhoe; Benton, Avery J; Lotti, James S; Rouzbeh, Nirvan; Hansen, Kasper B; Gouaux, Eric

发表日期：2026

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Gating and noelin clustering of native Ca(2+)-permeable AMPA receptors

天然Ca(2+)通透性AMPA受体的门控和noelin聚集

影响因子:48.5

doi:10.1038/s41586-025-09289-0

Fang, Chengli; Spangler, Cathy J; Park, Jumi; Sheldon, Natalie; Trussell, Laurence O; Gouaux, Eric

发表日期：2025

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The bile acid-sensitive ion channel is gated by Ca(2+)-dependent conformational changes in the transmembrane domain

胆汁酸敏感离子通道的门控机制是通过跨膜结构域中Ca²⁺依赖性的构象变化实现的。

期刊:Nature Communications

影响因子:15.7

doi:10.1038/s41467-025-62038-9

Freitas, Makayla M; Gouaux, Eric

发表日期：2025

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Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements

冷冻电镜对NMDA受体激活的快照揭示了序列重排

期刊:Science Advances

影响因子:12.5

doi:10.1126/sciadv.adx4647

Abbott, Jamie A; Kim, Junhoe; Liu, Beiying; Popescu, Gabriela K; Gouaux, Eric; Jalali-Yazdi, Farzad

发表日期：2025

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Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography

二聚体金纳米粒子可实现冷冻电镜断层扫描中的多重标记

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2524034122

Kim, Hoyoung; Spangler, Cathy J; Matsui, Aya; Elferich, Johannes; Kim, Junhoe; Roseborough, Alex; Nyman, May; Lahtinen, Tanja M; Gouaux, Eric

发表日期：2025

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Generation of Conformation-Specific Monoclonal Antibodies for Integral Membrane Proteins.

针对整合膜蛋白的构象特异性单克隆抗体的制备

期刊:Current Protocols

影响因子:2.2

doi:10.1002/cpz1.70142

Sheldon Natalie, Dhandapani Gunasekaran, Kim Junhoe, Spangler Cathy J, Fang Chengli, Park Jumi, Rao Prashant, Gouaux Eric

发表日期：2025

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The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction

秀丽隐杆线虫TMC-2复合物的结构表明，脂质介导的亚基接触在机械感觉转导中发挥作用。

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2314096121

Clark, Sarah; Jeong, Hanbin; Posert, Rich; Goehring, April; Gouaux, Eric

发表日期：2024

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Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

利用冷冻电镜断层扫描技术研究天然海马谷氨酸能突触

影响因子:6.4

doi:10.7554/eLife.98458

Matsui, Aya; Spangler, Cathy; Elferich, Johannes; Shiozaki, Momoko; Jean, Nikki; Zhao, Xiaowei; Qin, Maozhen; Zhong, Haining; Yu, Zhiheng; Gouaux, Eric

发表日期：2024

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