日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A phase II, multicenter, open-label, single-arm study of berzosertib plus topotecan in patients with relapsed platinum-resistant small-cell lung cancer (DDRiver SCLC 250)

一项 II 期、多中心、开放标签、单臂研究，评估 berzosertib 联合拓扑替康治疗复发性铂耐药小细胞肺癌患者的疗效（DDRiver SCLC 250）。

期刊:ESMO Open
影响因子:8.3
doi:10.1016/j.esmoop.2025.105918
Navarro, A; Thomas, A; Cheng, Y; Chen, Y; Reguart, N; Yoshida, T; Cousin, S; Dong, X; Yamamoto, N; Cappuzzo, F; Hallwachs, R; Bolleddula, J; Sarholz, B; Grombacher, T; Otte, M; Gounaris, I; Ferrer, J; Moulin, C; Paz-Ares, L
肺癌
肿瘤
肿瘤免疫
CLC
细胞生物学
发表日期：2026
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Pathway for the Development of ATR Inhibitors in Pediatric Malignancies: An ACCELERATE Multistakeholder Analysis

儿童恶性肿瘤中ATR抑制剂的研发路径：一项ACCELERATE多方利益相关者分析

期刊:Jco Precision Oncology
影响因子:5.6
doi:10.1200/PO-25-00642
Gatz, Susanne A; Glade-Bender, Julia; Pearson, Andrew D J; Ortiz, Michael V; Bernardi, Ronald; Chesler, Lou; Clifford, Steve; Cohen-Gogo, Sarah; De La Cuesta, Esther; de Rojas, Teresa; Durinck, Kaat; Federico, Sara; Fox, Elizabeth; George, Sally; Gounaris, Ioannis; Henssen, Anton George; Irwin, Meredith; Kool, Marcel; Lau, Alan; Nysom, Karsten; Pappo, Alberto; Pennock, Gregory K; Pfister, Stefan M; Scobie, Nicole; Slotkin, Emily K; Smith, Malcolm; Speleman, Frank; Stewart, Elizabeth A; Weigel, Brenda J; Vassal, Gilles
CEL
ATR
肿瘤
肿瘤免疫
发表日期：2026
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Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

综合群体药代动力学、药效学和安全性分析，为ATR抑制剂Tuvusertib的临床开发中的剂量选择提供信息

期刊:Clinical Pharmacology & Therapeutics
影响因子:5.5
doi:10.1002/cpt.70029
Mukker, Jatinder Kaur; Diderichsen, Paul Matthias; Hellmann, Farina; Yap, Timothy A; Plummer, Ruth; Tolcher, Anthony W; de Bono, Johann S; Gounaris, Ioannis; Szucs, Zoltan; Zimmermann, Astrid; Kareva, Irina; Bolleddula, Jayaprakasam; Seithel-Keuth, Annick; Locatelli, Giuseppe; Enderlin, Marta; Hicking, Christine; Zutshi, Anup; Gao, Wei; Strotmann, Rainer; Benincosa, Lisa; Venkatakrishnan, Karthik
ATR
发表日期：2026
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An Integrated Nonclinical and Clinical Risk Assessment of the Effects of Investigational ATRi Tuvusertib on QTc Interval in Patients With Solid Tumors

研究性ATRi药物Tuvusertib对实体瘤患者QTc间期影响的非临床和临床综合风险评估

期刊:Cts-Clinical and Translational Science
影响因子:2.8
doi:10.1111/cts.70496
Mukker, Jatinder Kaur; Yap, Timothy A; Tolcher, Anthony W; de Bono, Johann S; Plummer, Ruth; Grosser, Gary; van Amsterdam, Christoph; Schieferstein, Hanno; Witjes, Han; Diderichsen, Paul Matthias; Krebs-Brown, Axel; Gao, Wei; Strotmann, Rainer; Szucs, Zoltan; Gounaris, Ioannis; Venkatakrishnan, Karthik
ATR
发表日期：2026
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Epidemiology and Outcomes of Late-Onset Neonatal Sepsis in Preterm Infants in a Tertiary Hospital

三级医院早产儿晚发型新生儿败血症的流行病学及预后

期刊:Children-Basel
影响因子:2.1
doi:10.3390/children12050532
Kaffe, Katerina; Syrogiannopoulos, George A; Petinaki, Efthimia; Goudesidou, Maria; Kalaitzi, Anna; Gounaris, Antonios; Grivea, Ioanna N
败血症
发表日期：2025
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First-in-Human Study of the Ataxia Telangiectasia and Rad3-Related (ATR) Inhibitor Tuvusertib (M1774) as Monotherapy in Patients with Solid Tumors

首次人体研究：毛细血管扩张性共济失调和Rad3相关（ATR）抑制剂Tuvusertib（M1774）作为单药疗法治疗实体瘤患者

期刊:Clinical Cancer Research
影响因子:10.2
doi:10.1158/1078-0432.CCR-23-2409
Yap, Timothy A; Tolcher, Anthony W; Plummer, Ruth; Mukker, Jatinder Kaur; Enderlin, Marta; Hicking, Christine; Grombacher, Thomas; Locatelli, Giuseppe; Szucs, Zoltan; Gounaris, Ioannis; de Bono, Johann S
ATR
Human
发表日期：2024
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Relationship among DDR gene mutations, TMB and PD-L1 in solid tumour genomes identified using clinically actionable biomarker assays

利用临床可操作的生物标志物检测方法鉴定实体瘤基因组中DDR基因突变、TMB和PD-L1之间的关系

期刊:npj Precision Oncology
影响因子:8
doi:10.1038/s41698-023-00442-4
Wang, Danyi; Elenbaas, Brian; Murugesan, Karthikeyan; Shah, Kunal; Montesion, Meagan; Gounaris, Ioannis; Scheuenpflug, Juergen; Locatelli, Giuseppe; Feng, Zheng
PD-L1
发表日期：2023
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Gene targeting in amyotrophic lateral sclerosis using causality-based feature selection and machine learning

利用基于因果关系的特征选择和机器学习进行肌萎缩侧索硬化症的基因靶向治疗

期刊:Molecular Medicine
影响因子:6.4
doi:10.1186/s10020-023-00603-y
Founta, Kyriaki; Dafou, Dimitra; Kanata, Eirini; Sklaviadis, Theodoros; Zanos, Theodoros P; Gounaris, Anastasios; Xanthopoulos, Konstantinos
发表日期：2023
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Isolation of Secondary Metabolites from Achillea grandifolia Friv. (Asteraceae) and Main Compounds' Effects on a Glioblastoma Cellular Model

从大叶蓍草（Achillea grandifolia Friv.，菊科）中分离次生代谢产物及其主要化合物对胶质母细胞瘤细胞模型的影响

期刊:Pharmaceutics
影响因子:5.5
doi:10.3390/pharmaceutics15051383
Tsiftsoglou, Olga S; Krigas, Nikos; Gounaris, Christos; Papitsa, Christina; Nanouli, Maria; Vartholomatos, Evrysthenis; Markopoulos, Georgios S; Isyhou, Rafaela; Alexiou, George; Lazari, Diamanto
细胞生物学
代谢
发表日期：2023
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Exploring the Medicinal Potential of Achillea grandifolia in Greek Wild-Growing Populations: Characterization of Volatile Compounds, Anti-Inflammatory and Antioxidant Activities of Leaves and Inflorescences

探索希腊野生蓍草的药用潜力：叶片和花序挥发性化合物、抗炎和抗氧化活性的表征

期刊:Plants-Basel
影响因子:4.1
doi:10.3390/plants12030613
Tsiftsoglou, Olga S; Atskakani, Maria-Eleni; Krigas, Nikos; Stefanakis, Michalis K; Gounaris, Christos; Hadjipavlou-Litina, Dimitra; Lazari, Diamanto
发表日期：2023
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