日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mediator Kinase Inhibitor Selectivity and Activity in Colorectal Cancer

介导激酶抑制剂在结直肠癌中的选择性和活性

Ortiz-Ruiz, Maria J; Popoola, Olajumoke; Mitsopoulos, Konstantinos; Te-Poele, Robert; Samant, Rahul S; Box, Gary; Court, Will; Brandon, Alexis De Haven; Gowan, Sharon; Mallinger, Aurelie; Roe, Toby; Swabey, Kate; Valenti, Melanie; Al-Lazikani, Bissan; Blagg, Julian; Esdar, Christina; Schiemann, Kai; Wienke, Dirk; Eccles, Suzanne A; Workman, Paul; Clarke, Paul A

Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones

通过优化三环喹啉酮发现一种用于抑制BCL6的体内化学探针

Harnden, Alice C; Davis, Owen A; Box, Gary M; Hayes, Angela; Johnson, Louise D; Henley, Alan T; de Haven Brandon, Alexis K; Valenti, Melanie; Cheung, Kwai-Ming J; Brennan, Alfie; Huckvale, Rosemary; Pierrat, Olivier A; Talbot, Rachel; Bright, Michael D; Akpinar, Hafize Aysin; Miller, Daniel S J; Tarantino, Dalia; Gowan, Sharon; de Klerk, Selby; McAndrew, Peter Craig; Le Bihan, Yann-Vaï; Meniconi, Mirco; Burke, Rosemary; Kirkin, Vladimir; van Montfort, Rob L M; Raynaud, Florence I; Rossanese, Olivia W; Bellenie, Benjamin R; Hoelder, Swen

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies

HSF1通路抑制剂临床候选药物(CCT361814/NXP800)基于表型筛选开发,有望用于治疗难治性卵巢癌和其他恶性肿瘤。

Pasqua, A Elisa; Sharp, Swee Y; Chessum, Nicola E A; Hayes, Angela; Pellegrino, Loredana; Tucker, Michael J; Miah, Asadh; Wilding, Birgit; Evans, Lindsay E; Rye, Carl S; Mok, N Yi; Liu, Manjuan; Henley, Alan T; Gowan, Sharon; De Billy, Emmanuel; Te Poele, Robert; Powers, Marissa; Eccles, Suzanne A; Clarke, Paul A; Raynaud, Florence I; Workman, Paul; Jones, Keith; Cheeseman, Matthew D

Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo

提高结合亲和力和药代动力学可实现体内BCL6的持续降解

Huckvale, Rosemary; Harnden, Alice C; Cheung, Kwai-Ming J; Pierrat, Olivier A; Talbot, Rachel; Box, Gary M; Henley, Alan T; de Haven Brandon, Alexis K; Hallsworth, Albert E; Bright, Michael D; Akpinar, Hafize Aysin; Miller, Daniel S J; Tarantino, Dalia; Gowan, Sharon; Hayes, Angela; Gunnell, Emma A; Brennan, Alfie; Davis, Owen A; Johnson, Louise D; de Klerk, Selby; McAndrew, Craig; Le Bihan, Yann-Vaï; Meniconi, Mirco; Burke, Rosemary; Kirkin, Vladimir; van Montfort, Rob L M; Raynaud, Florence I; Rossanese, Olivia W; Bellenie, Benjamin R; Hoelder, Swen

Decreased levels of BAG3 in a family with a rare variant and in idiopathic dilated cardiomyopathy

患有罕见变异的家族中 BAG3 水平降低以及特发性扩张型心肌病

Arthur M Feldman, Rene L Begay, Tijana Knezevic, Valerie D Myers, Dobromir B Slavov, Weizhong Zhu, Katherine Gowan, Sharon L Graw, Kenneth L Jones, Douglas G Tilley, Ryan C Coleman, Paul Walinsky, Joseph Y Cheung, Luisa Mestroni, Kamel Khalili, Mathew R G Taylor

Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRα/β

通过联合靶向PDGFRα/β增强IGF1R抑制剂在儿童胶质母细胞瘤中的疗效

Bielen, Aleksandra; Perryman, Lara; Box, Gary M; Valenti, Melanie; de Haven Brandon, Alexis; Martins, Vanessa; Jury, Alexa; Popov, Sergey; Gowan, Sharon; Jeay, Sebastien; Raynaud, Florence I; Hofmann, Francesco; Hargrave, Darren; Eccles, Suzanne A; Jones, Chris

Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma.

对新型 HSP90 抑制剂 NVP-AUY922 在成人和儿童胶质母细胞瘤中的机制评价

Gaspar Nathalie, Sharp Swee Y, Eccles Suzanne A, Gowan Sharon, Popov Sergey, Jones Chris, Pearson Andrew, Vassal Gilles, Workman Paul