日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment

ATR抑制剂ceralasertib通过调节肿瘤微环境增强癌症检查点免疫疗法的疗效。

Elizabeth L Hardaker # ,Emilio Sanseviero # ,Ankur Karmokar # ,Devon Taylor # ,Marta Milo ,Chrysis Michaloglou ,Adina Hughes ,Mimi Mai ,Matthew King ,Anisha Solanki ,Lukasz Magiera ,Ricardo Miragaia ,Gozde Kar ,Nathan Standifer ,Michael Surace ,Shaan Gill ,Alison Peter ,Sara Talbot ,Sehmus Tohumeken ,Henderson Fryer ,Ali Mostafa ,Kathy Mulgrew ,Carolyn Lam ,Scott Hoffmann ,Daniel Sutton ,Larissa Carnevalli ,Fernando J Calero-Nieto ,Gemma N Jones ,Andrew J Pierce ,Zena Wilson ,David Campbell ,Lynet Nyoni ,Carla P Martins ,Tamara Baker ,Gilberto Serrano de Almeida ,Zainab Ramlaoui ,Abdel Bidar ,Benjamin Phillips ,Joseph Boland ,Sonia Iyer ,J Carl Barrett ,Arsene-Bienvenu Loembé ,Serge Y Fuchs ,Umamaheswar Duvvuri ,Pei-Jen Lou ,Melonie A Nance ,Carlos Alberto Gomez Roca ,Elaine Cadogan ,Susan E Critichlow ,Steven Fawell ,Mark Cobbold ,Emma Dean ,Viia Valge-Archer ,Alan Lau ,Dmitry I Gabrilovich ,Simon T Barry

Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models

抗 CD73 和抗 PD-L1 单克隆抗体联合细胞毒疗法的疗效和药效学作用:来自小鼠肿瘤模型的观察

Brajesh P Kaistha, Gozde Kar, Andreas Dannhorn, Amanda Watkins, Grace Opoku-Ansah, Kristina Ilieva, Stefanie Mullins, Judith Anderton, Elena Galvani, Fabien Garcon, Jean-Martin Lapointe, Lee Brown, James Hair, Tim Slidel, Nadia Luheshi, Kelli Ryan, Elizabeth Hardaker, Simon Dovedi, Rakesh Kumar, Rob

Ferroptosis of tumour neutrophils causes immune suppression in cancer

肿瘤中性粒细胞的铁死亡会导致癌症免疫抑制。

Rina Kim # ,Ayumi Hashimoto # ,Nune Markosyan ,Vladimir A Tyurin ,Yulia Y Tyurina ,Gozde Kar ,Shuyu Fu ,Mohit Sehgal ,Laura Garcia-Gerique ,Andrew Kossenkov ,Bereket A Gebregziabher ,John W Tobias ,Kristin Hicks ,Rebecca A Halpin ,Nevena Cvetesic ,Hui Deng ,Laxminarasimha Donthireddy ,Andrew Greenberg ,Brian Nam ,Robert H Vonderheide ,Yulia Nefedova ,Valerian E Kagan ,Dmitry I Gabrilovich

Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer

使用新型反义寡核苷酸 AZD8701 直接靶向 Treg 中的 FOXP3,以缓解癌症中的免疫抑制

Alexey Revenko #, Larissa S Carnevalli #, Charles Sinclair #, Ben Johnson, Alison Peter, Molly Taylor, Lisa Hettrick, Melissa Chapman, Stephanie Klein, Anisha Solanki, Danielle Gattis, Andrew Watt, Adina M Hughes, Lukasz Magiera, Gozde Kar, Lucy Ireland, Deanna A Mele, Vasu Sah, Maneesh Singh, Josep

Mapping Rora expression in resting and activated CD4+ T cells

绘制静息和活化CD4+ T细胞中Rora的表达图谱

Liora Haim-Vilmovsky ,Johan Henriksson ,Jennifer A Walker ,Zhichao Miao ,Eviatar Natan ,Gozde Kar ,Simon Clare ,Jillian L Barlow ,Evelina Charidemou ,Lira Mamanova ,Xi Chen ,Valentina Proserpio ,Jhuma Pramanik ,Steven Woodhouse ,Anna V Protasio ,Mirjana Efremova ,Julian L Griffin ,Matt Berriman ,Gordon Dougan ,Jasmin Fisher ,John C Marioni ,Andrew N J McKenzie ,Sarah A Teichmann

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

肿瘤诱导 T 细胞中类固醇从头生物合成以逃避免疫

Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A Fonseca, Kousik Kundu, Lia S Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J Adams, Jacqueline D Shields, Sarah A Teichmann

Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth

单细胞RNA测序揭示了支持肿瘤生长的动态基质微环境

Sarah Davidson ,Mirjana Efremova ,Angela Riedel ,Bidesh Mahata ,Jhuma Pramanik ,Jani Huuhtanen ,Gozde Kar ,Roser Vento-Tormo ,Tzachi Hagai ,Xi Chen ,Muzlifah A Haniffa ,Jacqueline D Shields ,Sarah A Teichmann

A cellular census of human lungs identifies novel cell states in health and in asthma

人类肺部细胞普查确定了健康和哮喘中的新细胞状态

Felipe A Vieira Braga #, Gozde Kar #, Marijn Berg #, Orestes A Carpaij #, Krzysztof Polanski #, Lukas M Simon, Sharon Brouwer, Tomás Gomes, Laura Hesse, Jian Jiang, Eirini S Fasouli, Mirjana Efremova, Roser Vento-Tormo, Carlos Talavera-López, Marnix R Jonker, Karen Affleck, Subarna Palit, Paulina M

Single cell analysis of human foetal liver captures the transcriptional profile of hepatobiliary hybrid progenitors

对人类胎肝进行单细胞分析,可获得肝胆杂交祖细胞的转录谱。

Joe M Segal ,Deniz Kent ,Daniel J Wesche ,Soon Seng Ng ,Maria Serra ,Bénédicte Oulès ,Gozde Kar ,Guy Emerton ,Samuel J I Blackford ,Spyros Darmanis ,Rosa Miquel ,Tu Vinh Luong ,Ryo Yamamoto ,Andrew Bonham ,Wayel Jassem ,Nigel Heaton ,Alessandra Vigilante ,Aileen King ,Rocio Sancho ,Sarah Teichmann ,Stephen R Quake ,Hiromitsu Nakauchi ,S Tamir Rashid

Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

全基因组分析表明,IRE1a-XBP1 通路通过解决分泌压力和加速增殖来促进 T 辅助细胞分化

Jhuma Pramanik, Xi Chen, Gozde Kar, Johan Henriksson, Tomás Gomes, Jong-Eun Park, Kedar Natarajan, Kerstin B Meyer, Zhichao Miao, Andrew N J McKenzie, Bidesh Mahata, Sarah A Teichmann