日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia.

Polθ 活性调节 DNMT3A 缺陷型白血病对标准疗法的敏感性。

Le Bac Viet, Vekariya Umeshkumar, Toma Monika M, Nieborowska-Skorska Margaret, Caron Marie-Christine, Gozdecka Malgorzata, Haydar Zayd, Walsh Martin, Ghosh Jayashri, Vaughan-Williams Elaine, Podszywalow-Bartnicka Paulina, Kukuyan Anna-Mariya, Ziolkowska Sylwia, Atkins Jessica, Hadzijusufovic Emir, Chandramouly Gurushankar, Nejati Reza, Piwocka Katarzyna, Pomerantz Richard, Vassiliou George S, Huntly Brian J P, Valent Peter, Wasik Mariusz, Bellacosa Alfonso, Masson Jean-Yves, Gupta Gaorav P, Challen Grant A, Skorski Tomasz

BCOR mutations define a therapeutic vulnerability to DHODH Inhibition in acute myeloid leukemia

BCOR 突变决定了急性髓系白血病对 DHODH 抑制剂的治疗敏感性。

Robert, Florian; Badja, Cherif; Boushaki, Soraya; Degasperi, Andrea; Memari, Yasin; Momen, Sophie; Roumeliotis, Theodoros I; Kozik, Zuza; Gozdecka, Malgorzata; Choudhary, Jyoti; Vassiliou, George; Koh, Gene Cc; Nik-Zainal, Serena

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

线粒体代谢维持DNMT3A-R882突变克隆性造血

Malgorzata Gozdecka ,Monika Dudek # ,Sean Wen # ,Muxin Gu ,Richard J Stopforth ,Justyna Rak ,Aristi Damaskou ,Guinevere L Grice ,Matthew A McLoughlin ,Laura Bond ,Rachael Wilson ,George Giotopoulos ,Vijaya Mahalingam Shanmugiah ,Rula Bany Bakar ,Eliza Yankova ,Jonathan L Cooper ,Nisha Narayan ,Sarah J Horton ,Ryan Asby ,Dean C Pask ,Annalisa Mupo ,Graham Duddy ,Ludovica Marando ,Theodoros Georgomanolis ,Paul Carter ,Amirtha Priya Ramesh ,William G Dunn ,Clea Barcena ,Paolo Gallipoli ,Kosuke Yusa ,Slavé Petrovski ,Penny Wright ,Pedro M Quiros ,Christian Frezza ,James A Nathan ,Arthur Kaser ,Siddhartha Kar ,Konstantinos Tzelepis ,Jonathan Mitchell ,Margarete A Fabre ,Brian J P Huntly ,George S Vassiliou

Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis

端粒缩短成为衰老造血和白血病发生过程中克隆选择的工具

Matthew A McLoughlin #,Sruthi Cheloor Kovilakam #,William G Dunn #,Muxin Gu,Jake Tobin,Yash Pershad,Nicholas Williams,Daniel Leongamornlert,Kevin Dawson,Laura Bond,Ludovica Marando,Sean Wen,Rachael Wilson,Giampiero Valenzano,Vasiliki Symeonidou,Justyna Rak,Aristi Damaskou,Malgorzata Gozdecka,Xiaoxuan Liu,Clea Barcena,Josep Nomdedeu,Paul Costeas,Ioannis D Dimitriou,Edoardo Fiorillo,Valeria Orrù,Jose Guilherme de Almeida,Thomas McKerrell,Matthew Cullen,Irina Mohorianu,Theodora Foukaneli,Alan J Warren,Chi Wong,George Follows,Anna L Godfrey,Emma Gudgin,Francesco Cucca,Eoin McKinney,E Joanna Baxter,Moritz Gerstung,Jonathan Mitchell,Daniel Wiseman,Alexander G Bick,Margarete Fabre,Pedro M Quiros,Jyoti Nangalia,Siddhartha Kar,George S Vassiliou

DNA polymerase theta-mediated DNA repair is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells

DNA聚合酶θ介导的DNA修复是DNMT3A缺陷型白血病细胞的功能依赖性和治疗脆弱性所在。

Le, Bac Viet; Vekariya, Umeshkumar; Toma, Monika M; Nieborowska-Skorska, Margaret; Caron, Marie-Christine; Gozdecka, Malgorzata; Haydar, Zayd; Walsh, Martin; Ghosh, Jayashri; Vaughan-Williams, Elaine; Podszywalow-Bartnicka, Paulina; Kukuyan, Anna-Mariya; Ziolkowska, Sylwia; Hadzijusufovic, Emir; Chandramouly, Gurushankar; Piwocka, Katarzyna; Pomerantz, Richard; Vassiliou, George S; Huntly, Brian Jp; Valent, Peter; Bellacosa, Alfonso; Masson, Jean-Yves; Gupta, Gaorav P; Challen, Grant A; Skorski, Tomasz

Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages

METTL3的药理学抑制会影响特定的造血谱系。

Sturgess, Katherine; Yankova, Eliza; Vijayabaskar, M S; Isobe, Tomoya; Rak, Justyna; Kucinski, Iwo; Barile, Melania; Webster, Natalie A; Eleftheriou, Maria; Hannah, Rebecca; Gozdecka, Malgorzata; Vassiliou, George; Rausch, Oliver; Wilson, Nicola K; Göttgens, Berthold; Tzelepis, Konstantinos

Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes

白血病前期单细胞图谱揭示了突变特异性机制和基因程序,这些机制和程序可预测急性髓系白血病(AML)患者的预后。

Tomoya Isobe ,Iwo Kucinski ,Melania Barile ,Xiaonan Wang ,Rebecca Hannah ,Hugo P Bastos ,Shirom Chabra ,M S Vijayabaskar ,Katherine H M Sturgess ,Matthew J Williams ,George Giotopoulos ,Ludovica Marando ,Juan Li ,Justyna Rak ,Malgorzata Gozdecka ,Daniel Prins ,Mairi S Shepherd ,Sam Watcham ,Anthony R Green ,David G Kent ,George S Vassiliou ,Brian J P Huntly ,Nicola K Wilson ,Berthold Göttgens

Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis

转录变异通过细胞多样化和扰乱蛋白质合成加速白血病前期进程

Shikha Gupta ,Oliver M Dovey ,Ana Filipa Domingues ,Oliwia W Cyran ,Caitlin M Cash ,George Giotopoulos ,Justyna Rak ,Jonathan Cooper ,Malgorzata Gozdecka ,Liza Dijkhuis ,Ryan J Asby ,Noor Al-Jabery ,Victor Hernandez-Hernandez ,Sudhakaran Prabakaran ,Brian J Huntly ,George S Vassiliou ,Cristina Pina

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

小分子抑制剂METTL3作为对抗髓系白血病的策略

Eliza Yankova # ,Wesley Blackaby # ,Mark Albertella ,Justyna Rak ,Etienne De Braekeleer ,Georgia Tsagkogeorga ,Ewa S Pilka ,Demetrios Aspris ,Dan Leggate ,Alan G Hendrick ,Natalie A Webster ,Byron Andrews ,Richard Fosbeary ,Patrick Guest ,Nerea Irigoyen ,Maria Eleftheriou ,Malgorzata Gozdecka ,Joao M L Dias ,Andrew J Bannister ,Binje Vick ,Irmela Jeremias ,George S Vassiliou ,Oliver Rausch ,Konstantinos Tzelepis ,Tony Kouzarides

Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression

白血病诱导过程中的突变协同作用重塑了染色质的可及性、组蛋白修饰和三维 DNA 拓扑结构,从而改变了基因表达

Haiyang Yun, Nisha Narayan, Shabana Vohra, George Giotopoulos, Annalisa Mupo, Pedro Madrigal, Daniel Sasca, David Lara-Astiaso, Sarah J Horton, Shuchi Agrawal-Singh, Eshwar Meduri, Faisal Basheer, Ludovica Marando, Malgorzata Gozdecka, Oliver M Dovey, Aracely Castillo-Venzor, Xiaonan Wang, Paolo Gal