日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity

守护者泛素E3连接酶靶向癌症相关的APOBEC3脱氨酶进行降解,从而促进人类基因组的完整性。

Schwartz, Irene; Budroni, Valentina; Meyenberg, Mathilde; Hodakova, Zuzana; Hornegger, Harald; Hacker, Kathrin; Schwartz, Siegfried; Grabarczyk, Daniel B; Ehrmann, Julian F; Scinicariello, Sara; Haselbach, David; Menche, Jörg; Clausen, Tim; Karagöz, G Elif; Versteeg, Gijs A

Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control

UBR4复合物的结构:一种在真核生物蛋白质质量控制中起核心作用的巨型E4连接酶

Grabarczyk, Daniel B; Ehrmann, Julian F; Murphy, Paul; Yang, Woo Seok; Kurzbauer, Robert; Bell, Lillie E; Deszcz, Luiza; Neuhold, Jana; Schleiffer, Alexander; Shulkina, Alexandra; Lee, Juyeon; Shin, Jin Seok; Meinhart, Anton; Versteeg, Gijs A; Zavodszky, Eszter; Song, Hyun Kyu; Hegde, Ramanujan S; Clausen, Tim

ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213.

ATP 作为病原体相关分子模式,可激活 E3 泛素连接酶 RNF213

Ahel Juraj, Balci Arda, Faas Victoria, Grabarczyk Daniel B, Harmo Roosa, Squair Daniel R, Zhang Jiazhen, Roitinger Elisabeth, Lamoliatte Frederic, Mathur Sunil, Deszcz Luiza, Bell Lillie E, Lehner Anita, Williams Thomas L, Sowar Hanna, Meinhart Anton, Wood Nicola T, Clausen Tim, Virdee Satpal, Fletcher Adam J

TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases.

TRIM52 维持细胞健康,并受到多种巨型 E3 连接酶的严格蛋白水解控制

Shulkina Alexandra, Hacker Kathrin, Ehrmann Julian F, Budroni Valentina, Mandlbauer Ariane, Bock Johannes, Grabarczyk Daniel B, Edobor Genevieve, Cochella Luisa, Clausen Tim, Versteeg Gijs A

Crystal structure and interactions of the Tof1-Csm3 (Timeless-Tipin) fork protection complex

Tof1-Csm3(Timeless-Tipin)叉状保护复合物的晶体结构和相互作用

Grabarczyk, Daniel B