日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA

骨架碳氢化合物约束的核酸调节 RNA 的杂交动力学

Tamilselvan Rajasekaran, Graeme C Freestone, Rodrigo Galindo-Murillo, Barbara Lugato, Lorena Rico, Juan C Salinas, Hans Gaus, Michael T Migawa, Eric E Swayze, Thomas E Cheatham 3rd, Stephen Hanessian, Punit P Seth

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides

迈向下一代反义寡核苷酸:甲磺酰基磷酰胺修饰可改善间隙体反义寡核苷酸的治疗指数和作用持续时间

Brooke A Anderson, Graeme C Freestone, Audrey Low, Cheryl L De-Hoyos, William J Drury Iii, Michael E Østergaard, Michael T Migawa, Michael Fazio, W Brad Wan, Andres Berdeja, Eli Scandalis, Sebastien A Burel, Timothy A Vickers, Stanley T Crooke, Eric E Swayze, Xuehai Liang, Punit P Seth

Site-specific incorporation of 5'-methyl DNA enhances the therapeutic profile of gapmer ASOs

5'-甲基 DNA 的位点特异性结合增强了 gapmer ASO 的治疗特性

Guillermo Vasquez, Graeme C Freestone, W Brad Wan, Audrey Low, Cheryl Li De Hoyos, Jinghua Yu, Thazha P Prakash, Michael E Ǿstergaard, Xue-Hai Liang, Stanley T Crooke, Eric E Swayze, Michael T Migawa, Punit P Seth