日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis

线粒体代谢维持DNMT3A-R882突变克隆性造血

Malgorzata Gozdecka ,Monika Dudek # ,Sean Wen # ,Muxin Gu ,Richard J Stopforth ,Justyna Rak ,Aristi Damaskou ,Guinevere L Grice ,Matthew A McLoughlin ,Laura Bond ,Rachael Wilson ,George Giotopoulos ,Vijaya Mahalingam Shanmugiah ,Rula Bany Bakar ,Eliza Yankova ,Jonathan L Cooper ,Nisha Narayan ,Sarah J Horton ,Ryan Asby ,Dean C Pask ,Annalisa Mupo ,Graham Duddy ,Ludovica Marando ,Theodoros Georgomanolis ,Paul Carter ,Amirtha Priya Ramesh ,William G Dunn ,Clea Barcena ,Paolo Gallipoli ,Kosuke Yusa ,Slavé Petrovski ,Penny Wright ,Pedro M Quiros ,Christian Frezza ,James A Nathan ,Arthur Kaser ,Siddhartha Kar ,Konstantinos Tzelepis ,Jonathan Mitchell ,Margarete A Fabre ,Brian J P Huntly ,George S Vassiliou

Epi-microRNA mediated metabolic reprogramming counteracts hypoxia to preserve affinity maturation

表观遗传微RNA介导的代谢重编程可对抗缺氧,从而维持亲和力成熟

Rinako Nakagawa ,Miriam Llorian ,Sunita Varsani-Brown ,Probir Chakravarty ,Jeannie M Camarillo ,David Barry ,Roger George ,Neil P Blackledge ,Graham Duddy ,Neil L Kelleher ,Robert J Klose ,Martin Turner ,Dinis P Calado

Pathological mechanisms and candidate therapeutic approaches in the hearing loss of mice carrying human MIR96 mutations

携带人类MIR96突变的小鼠听力损失的病理机制和候选治疗方法

Morag A Lewis ,Maria Lachgar-Ruiz ,Francesca Di Domenico ,Graham Duddy ,Jing Chen ,Sergio Fernandez ,Matias Morin ,Gareth Williams ,Miguel Angel Moreno Pelayo ,Karen P Steel

Donor template delivery by recombinant adeno-associated virus for the production of knock-in mice

通过重组腺相关病毒递送供体模板以产生敲入小鼠

Graham Duddy, Katherine Courtis, Juliette Horwood, Jessica Olsen, Helen Horsler, Tina Hodgson, Sunita Varsani-Brown, Abdullah Abdullah, Laura Denti, Hollie Lane, Fabio Delaqua, Julia Janzen, Molly Strom, Ian Rosewell, Katharine Crawley, Benjamin Davies

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

肿瘤诱导 T 细胞中类固醇从头生物合成以逃避免疫

Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A Fonseca, Kousik Kundu, Lia S Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J Adams, Jacqueline D Shields, Sarah A Teichmann

Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation

全基因组 CRISPR 筛选 T 辅助细胞揭示激活与分化之间普遍存在的相互作用

Johan Henriksson ,Xi Chen ,Tomás Gomes ,Ubaid Ullah ,Kerstin B Meyer ,Ricardo Miragaia ,Graham Duddy ,Jhuma Pramanik ,Kosuke Yusa ,Riitta Lahesmaa ,Sarah A Teichmann

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

磷酸化蛋白质组学揭示帕金森病激酶 LRRK2 调节 Rab GTPases 的一个子集

Martin Steger, Francesca Tonelli, Genta Ito, Paul Davies, Matthias Trost, Melanie Vetter, Stefanie Wachter, Esben Lorentzen, Graham Duddy, Stephen Wilson, Marco As Baptista, Brian K Fiske, Matthew J Fell, John A Morrow, Alastair D Reith, Dario R Alessi, Matthias Mann

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

LRRK2 对 Rab10 磷酸化的 Phos-tag 分析:一种评估激酶功能和抑制剂的强效检测方法

Genta Ito, Kristina Katsemonova, Francesca Tonelli, Pawel Lis, Marco A S Baptista, Natalia Shpiro, Graham Duddy, Steve Wilson, Philip Wing-Lok Ho, Shu-Leong Ho, Alastair D Reith, Dario R Alessi

Targeting apoptosis signalling kinase-1 (ASK-1) does not prevent the development of neuropathy in streptozotocin-induced diabetic mice

针对凋亡信号激酶-1(ASK-1)并不能阻止链脲佐菌素诱发的糖尿病小鼠神经病变的发展

Victoria L Newton, Sumia Ali, Graham Duddy, Alan J Whitmarsh, Natalie J Gardiner

Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target

K390R ITK 激酶死亡转基因小鼠的表征——对 ITK 作为治疗靶点的意义

Angela Deakin, Graham Duddy, Steve Wilson, Steve Harrison, Judi Latcham, Mick Fulleylove, Sylvia Fung, Jason Smith, Mike Pedrick, Tom McKevitt, Leigh Felton, Joanne Morley, Diana Quint, Dilniya Fattah, Brian Hayes, Jade Gough, Roberto Solari