Graham M Lord相关文献与解析，生知库 | 链接生命科学的每一步

Pedro Durao ，Timothy Budden ，Karthik Mallela ，Martha Gutteridge ，Isabella Mataloni ，Shilpa Gurung ，Mirco Mastrangelo ，Luke Roberts ，Antonia Banyard ，Garry Ashton ，Graham M Lord ，Adam Hurlstone ，Sara Valpione ，Amaya Viros

免疫/内分泌

发表日期：2025

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The TH1 cell lineage-determining transcription factor T-bet suppresses TH2 gene expression by redistributing GATA3 away from TH2 genes

TH1 细胞谱系决定转录因子 T-bet 通过将 GATA3 从 TH2 基因中重新分配出来，抑制 TH2 基因表达

期刊:Nucleic Acids Research

影响因子:16.6

doi:10.1093/nar/gkac258

Arnulf Hertweck, Maria Vila de Mucha, Paul R Barber, Robert Dagil, Hayley Porter, Andres Ramos, Graham M Lord, Richard G Jenner

Organoids capture tissue-specific innate lymphoid cell development in mice and humans

类器官能够模拟小鼠和人类组织特异性固有淋巴细胞的发育。

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2022.111281

Geraldine M Jowett ，Emily Read ，Luke B Roberts ，Diana Coman ，Marta Vilà González ，Tomasz Zabinski ，Umar Niazi ，Rita Reis ，Tung-Jui Trieu ，Davide Danovi ，Eileen Gentleman ，Ludovic Vallier ，Michael A Curtis ，Graham M Lord ，Joana F Neves

Cyclin-dependent Kinase 9 as a Potential Target for Anti-TNF-resistant Inflammatory Bowel Disease

细胞周期蛋白依赖性激酶 9 作为抗 TNF 耐药炎症性肠病的潜在靶点

期刊:Cellular and Molecular Gastroenterology and Hepatology

影响因子:7.1

doi:10.1016/j.jcmgh.2022.05.011

Omer S Omer, Arnulf Hertweck, Luke B Roberts, Jonathan W Lo, Jennie N Clough, Ian Jackson, Eirini D Pantazi, Peter M Irving, Tom T MacDonald, Polychronis Pavlidis, Richard G Jenner, Graham M Lord

ILC1 drive intestinal epithelial and matrix remodelling

ILC1驱动肠上皮和基质重塑

期刊:Nature Materials

影响因子:37.2

doi:10.1038/s41563-020-0783-8

Geraldine M Jowett ，Michael D A Norman # ，Tracy T L Yu # ，Patricia Rosell Arévalo ，Dominique Hoogland ，Suzette T Lust ，Emily Read ，Eva Hamrud ，Nick J Walters ，Umar Niazi ，Matthew Wai Heng Chung ，Daniele Marciano ，Omer S Omer ，Tomasz Zabinski ，Davide Danovi ，Graham M Lord ，Jöns Hilborn ，Nicholas D Evans ，Cécile A Dreiss ，Laurent Bozec ，Oommen P Oommen ，Christian D Lorenz ，Ricardo M P da Silva ，Joana F Neves # ，Eileen Gentleman #

发表日期：2021

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MicroRNA-142 Critically Regulates Group 2 Innate Lymphoid Cell Homeostasis and Function

MicroRNA-142 对 2 型固有淋巴细胞的稳态和功能起着关键的调控作用

期刊:

影响因子:3.6

doi:10.4049/jimmunol.2000647.

Luke B Roberts,Geraldine M Jowett,Emily Read,Tomas Zabinski,Rita Berkachy,Murray E Selkirk,Ian Jackson,Umar Niazi,Nelomi Anandagoda,Masatake Araki,Kimi Araki,Jagath Kasturiarachchi,Chela James,Tariq Enver,Rachael Nimmo,Rita Reis,Jane K Howard,Joana F Neves,Graham M Lord

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells

调节性T细胞抑制CD4+ T细胞通过白细胞介素-2和Blimp-1依赖性途径获得细胞毒性功能

期刊:Immunity

影响因子:25.5

doi:10.1016/j.immuni.2019.12.007

Anna Śledzińska ，Maria Vila de Mucha ，Katharina Bergerhoff ，Alastair Hotblack ，Dafne Franz Demane ，Ehsan Ghorani ，Ayse U Akarca ，Maria A V Marzolini ，Isabelle Solomon ，Frederick Arce Vargas ，Martin Pule ，Masahiro Ono ，Benedict Seddon ，George Kassiotis ，Charlotte E Ariyan ，Thomas Korn ，Teresa Marafioti ，Graham M Lord ，Hans Stauss ，Richard G Jenner ，Karl S Peggs ，Sergio A Quezada

Exhausted CD4+ T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression

疟疾期间耗竭的 CD4+ T 细胞表现出 mTORc1 活性降低，与 T-bet 表达丧失相关

期刊:Journal of Immunology

影响因子:3.6

doi:10.4049/jimmunol.2000450

Ana Villegas-Mendez, Garima Khandelwal, Lucy M McGowan, Rebecca S Dookie, Michael J Haley, Charlotte George, David Sims, Graham M Lord, Linda V Sinclair, Richard G Jenner, Kevin N Couper

Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues

皮肤免疫激活先天淋巴细胞-单核细胞轴，调节 CD8+ 效应细胞向粘膜组织的募集

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-019-09969-2

Marija Zaric, Pablo D Becker, Catherine Hervouet, Petya Kalcheva, Andor Doszpoly, Negin Blattman, Lauren A O' Neill, Barbara Ibarzo Yus, Clement Cocita, Sung-Yun Kwon, Andrew H Baker, Graham M Lord, Linda S Klavinskis

microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance

microRNA-142 介导的磷酸二酯酶 3B 抑制关键调节外周免疫耐受

期刊:Journal of Clinical Investigation

影响因子:13.3

doi:10.1172/JCI124725

Nelomi Anandagoda, Joanna Cd Willis, Arnulf Hertweck, Luke B Roberts, Ian Jackson, M Refik Gökmen, Richard G Jenner, Jane K Howard, Graham M Lord

免疫

发表日期：2019

文献求助收藏

Systemic immunosuppression from ultraviolet radiation exposure inhibits cancer immunotherapy

紫外线辐射引起的全身免疫抑制会抑制癌症免疫疗法。

The TH1 cell lineage-determining transcription factor T-bet suppresses TH2 gene expression by redistributing GATA3 away from TH2 genes

TH1 细胞谱系决定转录因子 T-bet 通过将 GATA3 从 TH2 基因中重新分配出来，抑制 TH2 基因表达

Organoids capture tissue-specific innate lymphoid cell development in mice and humans

类器官能够模拟小鼠和人类组织特异性固有淋巴细胞的发育。

Cyclin-dependent Kinase 9 as a Potential Target for Anti-TNF-resistant Inflammatory Bowel Disease

细胞周期蛋白依赖性激酶 9 作为抗 TNF 耐药炎症性肠病的潜在靶点

ILC1 drive intestinal epithelial and matrix remodelling

ILC1驱动肠上皮和基质重塑

MicroRNA-142 Critically Regulates Group 2 Innate Lymphoid Cell Homeostasis and Function

MicroRNA-142 对 2 型固有淋巴细胞的稳态和功能起着关键的调控作用

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells

调节性T细胞抑制CD4+ T细胞通过白细胞介素-2和Blimp-1依赖性途径获得细胞毒性功能

Exhausted CD4+ T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression

疟疾期间耗竭的 CD4+ T 细胞表现出 mTORc1 活性降低，与 T-bet 表达丧失相关

Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues

皮肤免疫激活先天淋巴细胞-单核细胞轴，调节 CD8+ 效应细胞向粘膜组织的募集

microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance

microRNA-142 介导的磷酸二酯酶 3B 抑制关键调节外周免疫耐受