日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Novel regulators of heparan sulfate proteoglycans modulate cellular uptake of α-synuclein fibrils

新型硫酸乙酰肝素蛋白聚糖调节因子调控细胞对α-突触核蛋白原纤维的摄取

Benoît Vanderperre # ,Amitha Muraleedharan # ,Marie-France Dorion ,Frédérique Larroquette ,Esther Del Cid Pellitero ,Nishani Rajakulendran ,Carol X-Q Chen ,Roxanne Larivière ,Charlotte Michaud-Tardif ,Thomas Goiran ,Rony Chidiac ,Damien Lipuma ,Graham MacLeod ,Rhalena Thomas ,Zhangjie Wang ,Wolfgang E Reintsch ,Wen Luo ,Irina Shlaifer ,Fuming Zhang ,Ke Xia ,Zachary Steinhart ,Robert J Linhardt ,Jean-François Trempe ,Jian Liu ,Thomas M Durcan ,Stephane Angers ,Edward A Fon

Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes

利用磁控碳纳米管对化疗耐药性胶质母细胞瘤进行机械纳米手术

Xian Wang,Zheyuan Gong,Tiancong Wang,Junhui Law,Xin Chen,Siyi Wanggou,Jintian Wang,Binbin Ying,Michelle Francisco,Weifan Dong,Yi Xiong,Jerry J Fan,Graham MacLeod,Stephane Angers,Xuejun Li,Peter B Dirks,Xinyu Liu,Xi Huang,Yu Sun

The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma

CDK12 抑制剂 SR-4835 可作为分子胶,促进黑色素瘤中的细胞周期蛋白 K 降解

Thibault Houles #, Jonathan Boucher #, Geneviève Lavoie, Graham MacLeod, Sichun Lin, Stephane Angers, Philippe P Roux

Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity

发育和损伤反应转录状态的梯度定义了胶质母细胞瘤异质性的功能脆弱性

Laura M Richards #, Owen K N Whitley #, Graham MacLeod, Florence M G Cavalli, Fiona J Coutinho, Julia E Jaramillo, Nataliia Svergun, Mazdak Riverin, Danielle C Croucher, Michelle Kushida, Kenny Yu, Paul Guilhamon, Naghmeh Rastegar, Moloud Ahmadi, Jasmine K Bhatti, Danielle A Bozek, Naijin Li, Lilian

A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy

Norrin/Wnt替代抗体刺激内皮细胞屏障功能并挽救视网膜病变

Rony Chidiac, Md Abedin, Graham Macleod, Andy Yang, Pierre E Thibeault, Levi L Blazer, Jarrett J Adams, Lingling Zhang, Heidi Roehrich, Ha-Neul Jo, Somasekar Seshagiri, Sachdev S Sidhu, Harald J Junge, Stephane Angers

Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival

胶质母细胞瘤的单细胞染色质可及性分析确定了与较低生存率相关的侵袭性癌症干细胞群

Paul Guilhamon, Charles Chesnelong, Michelle M Kushida, Ana Nikolic, Divya Singhal, Graham MacLeod, Seyed Ali Madani Tonekaboni, Florence Mg Cavalli, Christopher Arlidge, Nishani Rajakulendran, Naghmeh Rastegar, Xiaoguang Hao, Rozina Hassam, Laura J Smith, Heather Whetstone, Fiona J Coutinho, Bettin

Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma

表观基因组的代谢调控驱动致命性婴儿室管膜瘤

Kulandaimanuvel Antony Michealraj,Sachin A Kumar,Leo J Y Kim,Florence M G Cavalli,David Przelicki,John B Wojcik,Alberto Delaidelli,Andrea Bajic,Olivier Saulnier,Graham MacLeod,Ravi N Vellanki,Maria C Vladoiu,Paul Guilhamon,Winnie Ong,John J Y Lee,Yanqing Jiang,Borja L Holgado,Alex Rasnitsyn,Ahmad A Malik,Ricky Tsai,Cory M Richman,Kyle Juraschka,Joonas Haapasalo,Evan Y Wang,Pasqualino De Antonellis,Hiromichi Suzuki,Hamza Farooq,Polina Balin,Kaitlin Kharas,Randy Van Ommeren,Olga Sirbu,Avesta Rastan,Stacey L Krumholtz,Michelle Ly,Moloud Ahmadi,Geneviève Deblois,Dilakshan Srikanthan,Betty Luu,James Loukides,Xiaochong Wu,Livia Garzia,Vijay Ramaswamy,Evgeny Kanshin,María Sánchez-Osuna,Ibrahim El-Hamamy,Fiona J Coutinho,Panagiotis Prinos,Sheila Singh,Laura K Donovan,Craig Daniels,Daniel Schramek,Mike Tyers,Samuel Weiss,Lincoln D Stein,Mathieu Lupien,Bradly G Wouters,Benjamin A Garcia,Cheryl H Arrowsmith,Poul H Sorensen,Stephane Angers , Nada Jabado , Peter B Dirks , Stephen C Mack , Sameer Agnihotri , Jeremy N Rich , Michael D Taylor

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

铜的生物利用度是结直肠癌中 KRAS 基因特异性的脆弱性

Léo Aubert #, Neethi Nandagopal #, Zachary Steinhart, Geneviève Lavoie, Sami Nourreddine, Jacob Berman, Marc K Saba-El-Leil, David Papadopoli, Sichun Lin, Traver Hart, Graham Macleod, Ivan Topisirovic, Louis Gaboury, Christoph J Fahrni, Daniel Schramek, Sylvain Meloche, Stephane Angers, Philippe P R

Functional Enhancers Shape Extrachromosomal Oncogene Amplifications

功能增强子塑造染色体外致癌基因扩增

Andrew R Morton, Nergiz Dogan-Artun, Zachary J Faber, Graham MacLeod, Cynthia F Bartels, Megan S Piazza, Kevin C Allan, Stephen C Mack, Xiuxing Wang, Ryan C Gimple, Qiulian Wu, Brian P Rubin, Shashirekha Shetty, Stephane Angers, Peter B Dirks, Richard C Sallari, Mathieu Lupien, Jeremy N Rich, Peter

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells

全基因组 CRISPR-Cas9 筛选揭示胶质母细胞瘤干细胞的遗传脆弱性和替莫唑胺敏感性机制

Graham MacLeod, Danielle A Bozek, Nishani Rajakulendran, Vernon Monteiro, Moloud Ahmadi, Zachary Steinhart, Michelle M Kushida, Helen Yu, Fiona J Coutinho, Florence M G Cavalli, Ian Restall, Xiaoguang Hao, Traver Hart, H Artee Luchman, Samuel Weiss, Peter B Dirks, Stephane Angers