日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Bypassing the immunosuppressive effects of CA125/MUC16 via re-engineered rituximab (NAV-006) to improve its antitumor activity in vivo.

通过重新设计的利妥昔单抗(NAV-006)绕过 CA125/MUC16 的免疫抑制作用,以提高其在体内的抗肿瘤活性

Grasso Luigi, Kline Bradford J, Nicolaides Nicholas C

NAV-001, a high-efficacy antibody-drug conjugate targeting mesothelin with improved delivery of a potent payload by counteracting MUC16/CA125 inhibitory effects

NAV-001 是一种高效抗体药物偶联物,靶向间皮素,通过拮抗 MUC16/CA125 的抑制作用,提高了有效载荷的递送效率。

Nicolaides, Nicholas C; Kline, J Bradford; Grasso, Luigi

Tumor-Shed Antigen Affects Antibody Tumor Targeting: Comparison of Two (89)Zr-Labeled Antibodies Directed against Shed or Nonshed Antigens

肿瘤脱落抗原影响抗体肿瘤靶向性:两种针对脱落抗原和非脱落抗原的(89)Zr标记抗体的比较

Lee, Jae-Ho; Kim, Heejung; Yao, Zhengsheng; Szajek, Lawrence P; Grasso, Luigi; Kim, Insook; Paik, Chang H

Antibody-based tumor vascular theranostics targeting endosialin/TEM1 in a new mouse tumor vascular model

基于抗体的肿瘤血管诊疗技术在新小鼠肿瘤血管模型中靶向内皮唾液酸蛋白/TEM1

Li, Chunsheng; Chacko, Ann-Marie; Hu, Jia; Hasegawa, Kosei; Swails, Jennifer; Grasso, Luigi; El-Deiry, Wafik S; Nicolaides, Nicholas; Muzykantov, Vladimir R; Divgi, Chaitanya R; Coukos, George

Co-development of diagnostic vectors to support targeted therapies and theranostics: essential tools in personalized cancer therapy

共同开发诊断载体以支持靶向治疗和诊疗一体化:个性化癌症治疗的关键工具

Nicolaides, Nicholas C; O'Shannessy, Daniel J; Albone, Earl; Grasso, Luigi

Development of 124I immuno-PET targeting tumor vascular TEM1/endosialin

开发靶向肿瘤血管TEM1/内皮唾液素的124I免疫PET

Chacko, Ann-Marie; Li, Chunsheng; Nayak, Madhura; Mikitsh, John L; Hu, Jia; Hou, Catherine; Grasso, Luigi; Nicolaides, Nicholas C; Muzykantov, Vladimir R; Divgi, Chaitanya R; Coukos, George

Bioconjugation by native chemical tagging of C-H bonds

通过天然化学标记CH键进行生物偶联

Zhou, Qianghui; Gui, Jinghan; Pan, Chung-Mao; Albone, Earl; Cheng, Xin; Suh, Edward M; Grasso, Luigi; Ishihara, Yoshihiro; Baran, Phil S

Gene expression analysis of tumor spheroids reveals a role for suppressed DNA mismatch repair in multicellular resistance to alkylating agents

肿瘤球体的基因表达分析揭示了DNA错配修复抑制在多细胞对烷化剂耐药性中的作用

Francia, Giulio; Man, Shan; Teicher, Beverly; Grasso, Luigi; Kerbel, Robert S