文献库，生知库 | 链接生命科学的每一步

日期影响因子

Non-canonical G(q) activation by orexin receptor type 2 and lemborexant observed in microsecond molecular dynamics simulations

在微秒分子动力学模拟中观察到食欲素受体2型和伦博雷生对非经典G(q)的激活作用

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-025-03857-0

Dragan, Paulina; Gratio, Valerie; Voisin, Thierry; Couvineau, Alain; Latek, Dorota

发表日期：2025

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Identification of the Axis β-Catenin-BTK in the Dynamic Adhesion of Chronic Lymphocytic Leukemia Cells to Their Microenvironment

慢性淋巴细胞白血病细胞与其微环境的动态粘附中 β-Catenin-BTK 轴的鉴定

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms242417623

Imane Mihoub, Tareck Rharass, Souhaïl Ouriemmi, Antonin Oudar, Laure Aubard, Valérie Gratio, Gregory Lazarian, Jordan Ferreira, Elisabetta Dondi, Florence Cymbalista, Vincent Levy, Fanny Baran-Marszak, Nadine Varin-Blank, Dominique Ledoux, Christine Le Roy, Laura Gardano

发表日期：2023

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The Orexin receptors: Structural and anti-tumoral properties

食欲素受体：结构和抗肿瘤特性

期刊:Frontiers in Endocrinology

影响因子:4.6

doi:10.3389/fendo.2022.931970

Couvineau, Alain; Nicole, Pascal; Gratio, Valérie; Voisin, Thierry

发表日期：2022

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The Orexin-A/OX1R System Induces Cell Death in Pancreatic Cancer Cells Resistant to Gemcitabine and Nab-Paclitaxel Treatment

Orexin-A/OX1R 系统诱导对吉西他滨和白蛋白紫杉醇治疗有耐药性的胰腺癌细胞死亡

期刊:Frontiers in Oncology

影响因子:3.5

doi:10.3389/fonc.2022.904327

Thierry Voisin, Pascal Nicole, Valérie Gratio, Anaïs Chassac, Dounia Mansour, Vinciane Rebours, Anne Couvelard, Alain Couvineau

细胞生物学

发表日期：2022

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Orexins: A promising target to digestive cancers, inflammation, obesity and metabolism dysfunctions

食欲素：消化系统癌症、炎症、肥胖和代谢功能障碍的潜在治疗靶点

期刊:World Journal of Gastroenterology

影响因子:5.4

doi:10.3748/wjg.v27.i44.7582

Couvineau, Alain; Voisin, Thierry; Nicole, Pascal; Gratio, Valerie; Blais, Anne

发表日期：2021

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Orexins/Hypocretins and Cancer: A Neuropeptide as Emerging Target

食欲素/下丘脑泌素与癌症：一种作为新兴靶点的神经肽

期刊:Molecules

影响因子:4.6

doi:10.3390/molecules26164849

Alain, Couvineau; Pascal, Nicole; Valérie, Gratio; Thierry, Voisin

免疫/内分泌

发表日期：2021

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Orexins as Novel Therapeutic Targets in Inflammatory and Neurodegenerative Diseases

食欲素作为炎症和神经退行性疾病的新型治疗靶点

期刊:Frontiers in Endocrinology

影响因子:4.6

doi:10.3389/fendo.2019.00709

Couvineau, Alain; Voisin, Thierry; Nicole, Pascal; Gratio, Valérie; Abad, Catalina; Tan, Yossan-Var

发表日期：2019

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The Anti-tumoral Properties of Orexin/Hypocretin Hypothalamic Neuropeptides: An Unexpected Therapeutic Role

下丘脑神经肽食欲素/下丘脑泌素的抗肿瘤特性：一种意想不到的治疗作用

期刊:Frontiers in Endocrinology

影响因子:4.6

doi:10.3389/fendo.2018.00573

Couvineau, Alain; Dayot, Stéphanie; Nicole, Pascal; Gratio, Valérie; Rebours, Vinciane; Couvelard, Anne; Voisin, Thierry

免疫/内分泌

发表日期：2018

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Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A

溃疡性结肠炎中 OX1R 异位表达介导 orexin-A 的抗炎作用

期刊:Biochimica et Biophysica Acta-Molecular Basis of Disease

影响因子:4.2

doi:10.1016/j.bbadis.2018.08.023

N Messal, N Fernandez, S Dayot, V Gratio, P Nicole, C Prochasson, I Chantret, G LeGuilloux, A Jarry, A Couvelard, X Tréton, T Voisin, E Ogier-Denis, A Couvineau

发表日期：2018

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In vitro, in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma

体外、体内和离体证明下丘脑分泌素-1/食欲素-A 和阿莫雷森在胰腺导管腺癌中的抗肿瘤作用

期刊:Oncotarget

doi:10.18632/oncotarget.24084

Stéphanie Dayot #, Daniela Speisky #, Anne Couvelard, Pierre Bourgoin, Valérie Gratio, Jérôme Cros, Vinciane Rebours, Alain Sauvanet, Pierre Bedossa, Valérie Paradis, Philippe Ruszniewski, Alain Couvineau, Thierry Voisin

Fluorescence microscopy

发表日期：2018

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