日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

OGFOD1 enables AML chemo- and nutrient stress resistance by regulating protein synthesis

OGFOD1通过调节蛋白质合成,使AML细胞能够抵抗化疗和营养胁迫。

Christina Mayerhofer ,Dan Li ,Trine Kristiansen ,Ernst Mayerhofer ,Azeem Sharda ,Giulia Schiroli ,Karin Gustafsson ,Lingli He ,Michael Mazzola ,Sam Keyes ,Anna Kiem ,Eve Crompton ,Yanxin Xu ,Sovannarith Korm ,Zhixun Dou ,Charles Vidoudez ,Peter G Miller ,Nick van Gastel ,Timothy A Graubert ,David T Scadden

Integrative cytogenetic and molecular studies unmask "chromosomal mimicry" in hematologic malignancies

整合细胞遗传学和分子生物学研究揭示血液系统恶性肿瘤中的“染色体模拟”现象

Zhao, Melissa; Ryall, Scott; Brody, Samuel J; Harris, Amyah C; Cabral, Kristin; Brownstein, Catherine; Kim, Jaeseung C; Smith, Adam C; Dal Cin, Paola; Narayan, Rupa; Sikkink, Kristin; Schmitt, Anthony; Hobbs, Gabriela S; Fathi, Amir T; Griffin, Gabriel K; Sait, Sheila N J; Iafrate, Anthony J; Aster, Jon C; Graubert, Timothy A; Nardi, Valentina; Dubuc, Adrian M

Sensitivity to ATR-CHK1 pathway inhibition in AML/MDS is enhanced by SRSF2 mutations and reduced by RUNX1 loss

在急性髓系白血病/骨髓增生异常综合征中,SRSF2 突变会增强对 ATR-CHK1 通路抑制的敏感性,而 RUNX1 缺失则会降低这种敏感性。

Eldfors, Samuli; Rai, Sumit; Sharma, Vineet; Hossan, Tareq; Pastrana, Claudia Cabrera; Bertino, Amy; Gilbert, Angelique; Porkka, Kimmo; Walter, Matthew; Graubert, Timothy A

Sialylated CD43 is a glyco-immune checkpoint for macrophage phagocytosis

唾液酸化的CD43是巨噬细胞吞噬作用的糖基免疫检查点

Chung, Jooho; Vallurupalli, Mounica; Noel, Sarah; Schor, Gail; Liu, YuhJong; Nobrega, Celeste; Perera, Jonathan J; Wrona, Ewa; Hu, Margaret; Lin, Yunkang; Wu, David W; Saberi, Maria; Scapozza, Ilario; Cruickshank, Aidan; Woods, Elliot C; Chuong, Cun Lan; Birocchi, Filippo; Kammula, Ashwin V; Avila, Omar I; Kocak, Mustafa; Doench, John G; Procter, Dean; Thornton, Lindsey; Brunner, Andrew M; Winer, Eric; DeAngelo, Daniel J; Garcia, Jacqueline S; Stone, Richard M; Jenkins, Russell W; Maus, Marcela V; Graubert, Timothy A; Yates, Kathleen B; Golub, Todd R; Manguso, Robert T

U2af1 (S34F) and U2af1 (Q157R) myeloid neoplasm-associated hotspot mutations induce distinct hematopoietic phenotypes in mice

U2af1 (S34F) 和 U2af1 (Q157R) 髓系肿瘤相关热点突变在小鼠中诱导不同的造血表型。

Alberti, Michael O; Srivatsan, Sridhar Nonavinkere; Shao, Jin; Fei, Dennis L; Zhu, Mengou; Pastrana, Clauida Cabrera; Grieb, Sarah; Graubert, Timothy A; Abdel-Wahab, Omar; Walter, Matthew J

Supporting Patients with Cancer after Dobbs v. Jackson Women's Health Organization

在多布斯诉杰克逊妇女健康组织案之后,为癌症患者提供支持

Shuman, Andrew G; Aapro, Matti S; Anderson, Benjamin; Arbour, Katherine; Barata, Pedro C; Bardia, Aditya; Bruera, Eduardo; Chabner, Bruce A; Chen, Herbert; Choy, Edwin; Conte, Pierfranco; Curigliano, Giuseppe; Dizon, Don; O'Reilly, Eileen; Tito Fojo, Antonio; Gelderblom, Hans; Graubert, Timothy A; Gurtler, Jayne S; Hall, Evan; Hirsch, Fred R; Idbaih, Ahmed; Ilson, David H; Kelley, Michael; La Vecchia, Carlo; Ludwig, Heinz; Moy, Beverly; Muss, Hyman; Opdam, Frans; Pentz, Rebecca D; Posner, Marshall R; Ross, Jeffrey S; Sacher, Adrian; Senan, Suresh; Perez de Celis, Enrique Soto; Tanabe, Kenneth K; Vermorken, Jan B; Wehrenberg-Klee, Eric; Bates, Susan E

Implementation and Clinical Adoption of Precision Oncology Workflows Across a Healthcare Network

在医疗保健网络中实施和临床应用精准肿瘤学工作流程

Dias-Santagata, Dora; Heist, Rebecca S; Bard, Adam Z; da Silva, Annacarolina F L; Dagogo-Jack, Ibiayi; Nardi, Valentina; Ritterhouse, Lauren L; Spring, Laura M; Jessop, Nicholas; Farahani, Alexander A; Mino-Kenudson, Mari; Allen, Jill; Goyal, Lipika; Parikh, Aparna; Misdraji, Joseph; Shankar, Ganesh; Jordan, Justin T; Martinez-Lage, Maria; Frosch, Matthew; Graubert, Timothy; Fathi, Amir T; Hobbs, Gabriela S; Hasserjian, Robert P; Raje, Noopur; Abramson, Jeremy; Schwartz, Joel H; Sullivan, Ryan J; Miller, David; Hoang, Mai P; Isakoff, Steven; Ly, Amy; Bouberhan, Sara; Watkins, Jaclyn; Oliva, Esther; Wirth, Lori; Sadow, Peter M; Faquin, William; Cote, Gregory M; Hung, Yin P; Gao, Xin; Wu, Chin-Lee; Garg, Salil; Rivera, Miguel; Le, Long P; John Iafrate, A; Juric, Dejan; Hochberg, Ephraim P; Clark, Jeffrey; Bardia, Aditya; Lennerz, Jochen K

CLINICAL AND RADIOLOGICAL FINDINGS IN PEDIATRIC PATIENTS WITH ACUTE LEUKEMIA DURING COVID-19 INFECTION - WHAT HAVE WE LEARNED?

COVID-19 感染期间急性白血病患儿的临床和放射学发现——我们学到了什么?

Klco, Jeffery M; Spencer, David H; Miller, Christopher A; Griffith, Malachi; Lamprecht, Tamara L; O'Laughlin, Michelle; Fronick, Catrina; Magrini, Vincent; Demeter, Ryan T; Fulton, Robert S; Eades, William C; Link, Daniel C; Graubert, Timothy A; Walter, Matthew J; Mardis, Elaine R; Dipersio, John F; Wilson, Richard K; Ley, Timothy J; Mota, FO; Lederman, HM; Carlesse, FAMC; Silva, AMPS; Grossman, I; Michalowski, MB; Santos, NS; Delbuono, E; Sousa, AVL

U2af1 is a haplo-essential gene required for hematopoietic cancer cell survival in mice

U2af1 是小鼠造血癌细胞存活所必需的单倍体必需基因

Brian A Wadugu, Sridhar Nonavinkere Srivatsan, Amanda Heard, Michael O Alberti, Matthew Ndonwi, Jie Liu, Sarah Grieb, Joseph Bradley, Jin Shao, Tanzir Ahmed, Cara L Shirai, Ajay Khanna, Dennis L Fei, Christopher A Miller, Timothy A Graubert, Matthew J Walter

A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex

一种合成小分子通过促进早期 U2AF2-RNA 复合物来阻止前 mRNA 剪接

Rakesh Chatrikhi, Callen F Feeney, Mary J Pulvino, Georgios Alachouzos, Andrew J MacRae, Zackary Falls, Sumit Rai, William W Brennessel, Jermaine L Jenkins, Matthew J Walter, Timothy A Graubert, Ram Samudrala, Melissa S Jurica, Alison J Frontier, Clara L Kielkopf