日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Clinical trial success rate in lymphoma: fate of trials and agents from 2000 to 2019

淋巴瘤临床试验成功率:2000年至2019年试验和药物的命运

Luo, Zhiping; Li, Meng; Primeaux, Brian C; Shah, Rahul; Lin, Ruitao; Iyer, Swaminathan P; Nastoupil, Loretta J; Green, Michael R; Westin, Jason R; Flowers, Christopher R; Chihara, Dai

The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation.

白血病中发现的 SETD2 L1609P 突变会破坏甲基转移酶活性,降低组蛋白 H3K36 三甲基化。

Michail Christina, Berthelet Jérémy, Mechaly Ariel E, Bui Linh-Chi, Yang Haopeng, Cai Duo, Al Mahi Amira, Xie Aowei, Bisio Valeria, Sirri Valentina, Dupret Jean-Marie, Guidez Fabien, Xu Ximing, Joly Nicolas, Regad Leslie, Viguier Mireille, Deshayes Frédérique, Dulphy Nicolas, Green Michael R, Haouz Ahmed, Rodrigues Lima Fernando

Proteome landscape of B-cell malignancies identifies mantle cell lymphoma protein signature

B细胞恶性肿瘤的蛋白质组图谱揭示了套细胞淋巴瘤的蛋白质特征

Swenson, Samantha A; Winship, C Bea; Dobish, Kasidy K; Wittorf, Karli J; Law, Henry Ch; Vose, Julie M; Greiner, Timothy; Green, Michael R; Woods, Nicholas T R; Buckley, Shannon M

A patient derived xenograft repository capturing clinical and molecular heterogeneity of large B-cell lymphoma

一个源自患者的异种移植模型库,用于捕捉大B细胞淋巴瘤的临床和分子异质性

Yang, Haopeng; Arita, Kotaro; Bowman, Kevin; Chihara, Dai; Henderson, Jared; Rost, Griffin; Rojas, Estela; Parsons, Sydney; Lakra, Priya; Abedin, Aneela; Neelapu, Sattva S; Strati, Paolo; Nastoupil, Loretta J; Fayad, Luis; Iyer, Swaminathan P; Rodriguez, Alma; Hagemeister, Frederick B; Malpica, Luis; Lee, Hun Ju; Hilton, Laura; Scott, David W; Davis, Richard Eric; Flowers, Christopher R; Westin, Jason R; Inghirami, Giorgio; Vega, Francisco; Green, Michael R

Multi-modal spatial characterization of tumor immune microenvironments identifies targetable inflammatory niches in diffuse large B cell lymphoma

肿瘤免疫微环境的多模态空间表征可识别弥漫性大B细胞淋巴瘤中可靶向的炎症微环境

Dai, Yibo; Kizhakeyil, Atish; Chihara, Dai; Li, Xubin; Liu, Yunhe; Sainz Zuniga, Tania Patricia; Wilson, Ashley; Henderson, Jared; Vibe, Daniil; Petrosyants, Arman; Jacobson, Connor; Sarachakov, Alexander; Nomie, Krystle; Kryukov, Kirill; Bagaev, Aleksander; Chauhan, Ayushi; Westin, Jason R; Flowers, Christopher R; Vega, Francisco; Wang, Linghua; Green, Michael R

Blunted CD40-responsive enhancer activation in CREBBP-mutant lymphomas can be restored by enforced CD4 T-cell engagement

CREBBP突变淋巴瘤中CD40反应性增强子激活减弱可通过强制CD4 T细胞参与来恢复。

Yang, Haopeng; Zhang, Wenchao; Ravanmehr, Vida; Cui, Guiling; Bowman, Kevin; Chen, Ruidong; Henderson, Jared M; Lockman, Shyanne; Rojas, Estela; Wilson, Ashley; Parsons, Sydney; Mechaly, Ariel; Regad, Leslie; Haouz, Ahmed; Flowers, Christopher R; Neelapu, Sattva; Nastoupil, Loretta; Davis, R Eric; Deng, Qing; Rodrigues-Lima, Fernando; Green, Michael R

Targeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype

靶向microRNA依赖的X染色体失活调控可改善雷特综合征表型

Lou, Song; DJiake Tihagam, Rachisan; Wasko, Urszula N; Equbal, Zaffar; Venkatesan, Sanjay; Braczyk, Klaudia; Przanowski, Piotr; Il Koo, Bon; Saltani, Ilyas; Singh, Arjun Tushir; Likhite, Shibi; Powers, Samantha; Souza, George M P R; Maxwell, Robert A; Yu, Jun; Zhu, Lihua J; Beenhakker, Mark; Abbott, Stephen B G; Lu, Zhipeng; Green, Michael R; Meyer, Kathrin C; Tushir-Singh, Jogender; Bhatnagar, Sanchita

Multiomic analysis reveals a key BCAT1 role in mTOR activation by B cell receptor and TLR9

多组学分析揭示了BCAT1在B细胞受体和TLR9激活mTOR中的关键作用

Guo, Rui; Sun, Yizhe; Lim, Matthew Y; Shah, Hardik; Paulo, Joao A; Ahmed, Rahaman A; Li, Weixing; Zhang, Yuchen; Yang, Haopeng; Wang, Liang Wei; Strebinger, Daniel; Smith, Nicholas A; Li, Meng; Leong, Merrin Man Long; Lutchenkov, Michael; Liang, Jin Hua; Li, Zhixuan; Wang, Yin; Puri, Rishi; Melnick, Ari; Green, Michael R; Asara, John M; Papathanassiu, Adonia E; Wesemann, Duane R; Gygi, Steven P; Mootha, Vamsi K; Gewurz, Benjamin E

PPT1 is a negative regulator of STING signaling in cancer cells and its inhibition reactivates immune surveillance in cold tumors

PPT1是癌细胞中STING信号的负调控因子,抑制PPT1可以重新激活冷肿瘤中的免疫监视功能。

Chowdhury, Shreya R; Parikh, Chaitanya N; Kaur, Arshia N; DeMarco, Kelly D; Giwa, Hadiya K; Mishra, Alok K; Murphy, Katherine C; Zhou, Lin; Ma, Boyang; Ye, Tianyi; Li, Junhui; Liu, Haibo; Bai, Shi; Johnson, Calvin; Simin, Karl; Pitarresi, Jason R; Zhu, Lihua Julie; Watson, Emma V; Kelliher, Michelle A; Green, Michael R; Fitzgerald, Katherine A; Ruscetti, Marcus

Inhibition of Rho-Associated Kinases ROCK1 and ROCK2 as a Therapeutic Strategy to Reactivate the Repressed FXN Gene in Friedreich Ataxia

抑制 Rho 相关激酶 ROCK1 和 ROCK2 作为治疗弗里德赖希共济失调症中激活被抑制的 FXN 基因的策略

Fang, Minggang; Banday, Shahid; Deibler, Sara K; Simone, Tessa M; Coleman, Madison; O'Connor, Emerald; Li, Rui; Zhu, Lihua Julie; Green, Michael R