日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An enhanced intracellular delivery platform based on a distant diphtheria toxin homolog that evades pre-existing antitoxin antibodies

一种基于远缘白喉毒素同源物的增强型细胞内递送平台,可逃避预先存在的抗毒素抗体。

Shivneet K Gill,Seiji N Sugiman-Marangos,Greg L Beilhartz,Elizabeth Mei,Mikko Taipale,Roman A Melnyk

Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins

梭菌致死毒素对信号蛋白的识别揭示了梭菌毒素受体特异性的原理

Hunsang Lee,Greg L Beilhartz,Iga Kucharska,Swetha Raman,Hong Cui,Mandy Hiu Yi Lam,Huazhu Liang,John L Rubinstein,Daniel Schramek,Jean-Philippe Julien,Roman A Melnyk,Mikko Taipale

Exploiting the diphtheria toxin internalization receptor enhances delivery of proteins to lysosomes for enzyme replacement therapy

利用白喉毒素内化受体增强蛋白质向溶酶体的输送,用于酶替代疗法

Seiji N Sugiman-Marangos, Greg L Beilhartz, Xiaochu Zhao, Dongxia Zhou, Rong Hua, Peter K Kim, James M Rini, Berge A Minassian, Roman A Melnyk

Attenuated diphtheria toxin mediates siRNA delivery

减毒白喉毒素介导 siRNA 递送

Amy E Arnold, Laura J Smith, Greg L Beilhartz, Laura C Bahlmann, Emma Jameson, Roman A Melnyk, Molly S Shoichet

Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota

宿主靶向氯硝柳胺可抑制艰难梭菌的毒力,并在不破坏肠道菌群的情况下预防小鼠发病

John Tam, Therwa Hamza, Bing Ma, Kevin Chen, Greg L Beilhartz, Jacques Ravel, Hanping Feng, Roman A Melnyk