日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis

全基因组 CRISPRi 筛选确定了结核分枝杆菌异烟肼耐药菌株的药物脆弱性

XinYue Wang, William J Jowsey, Chen-Yi Cheung, Caitlan J Smart, Hannah R Klaus, Noon Ej Seeto, Natalie Je Waller, Michael T Chrisp, Amanda L Peterson, Boatema Ofori-Anyinam, Emily Strong, Brunda Nijagal, Nicholas P West, Jason H Yang, Peter C Fineran, Gregory M Cook, Simon A Jackson, Matthew B McNei

Catalyst-free late-stage functionalization to assemble α-acyloxyenamide electrophiles for selectively profiling conserved lysine residues

无催化剂后期功能化组装 α-酰氧基酰胺亲电试剂以选择性分析保守的赖氨酸残基

Yuanyuan Zhao #, Kang Duan #, Youlong Fan #, Shengrong Li #, Liyan Huang, Zhengchao Tu, Hongyan Sun, Gregory M Cook, Jing Yang, Pinghua Sun, Yi Tan, Ke Ding, Zhengqiu Li

Marine sponge microbe provides insights into evolution and virulence of the tubercle bacillus

海洋海绵微生物为结核杆菌的进化和毒力提供了见解

Sacha J Pidot, Stephan Klatt, Louis S Ates, Wafa Frigui, Fadel Sayes, Laleh Majlessi, Hiroshi Izumi, Ian R Monk, Jessica L Porter, Vicki Bennett-Wood, Torsten Seemann, Ashley Otter, George Taiaroa, Gregory M Cook, Nicholas West, Nicholas J Tobias, John A Fuerst, Michael D Stutz, Marc Pellegrini, Mal

The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis

抗生素耐药性的演变与结核分枝杆菌的附带药物表型有关

Natalie J E Waller, Chen-Yi Cheung, Gregory M Cook, Matthew B McNeil

Impaired Succinate Oxidation Prevents Growth and Influences Drug Susceptibility in Mycobacterium tuberculosis

琥珀酸氧化受损会阻碍结核分枝杆菌的生长并影响其药物敏感性

Cara Adolph, Matthew B McNeil, Gregory M Cook

RNase HI Depletion Strongly Potentiates Cell Killing by Rifampicin in Mycobacteria

RNase HI 消耗可显著增强利福平对分枝杆菌细胞的杀伤力

Abeer Al-Zubaidi, Chen-Yi Cheung, Gregory M Cook, George Taiaroa, Valerie Mizrahi, J Shaun Lott, Stephanie S Dawes

The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB

结核分枝杆菌 bd 氧化酶的低温电子显微镜结构揭示了独特的结构框架,并有助于合理设计药物来对抗结核病

Schara Safarian, Helen K Opel-Reading, Di Wu, Ahmad R Mehdipour, Kiel Hards, Liam K Harold, Melanie Radloff, Ian Stewart, Sonja Welsch, Gerhard Hummer, Gregory M Cook, Kurt L Krause, Hartmut Michel

Cellular and Structural Basis of Synthesis of the Unique Intermediate Dehydro-F420-0 in Mycobacteria

分枝杆菌中独特中间体脱氢-F420-0合成的细胞和结构基础

Rhys Grinter, Blair Ney, Rajini Brammananth, Christopher K Barlow, Paul R F Cordero, David L Gillett, Thierry Izoré, Max J Cryle, Liam K Harold, Gregory M Cook, George Taiaroa, Deborah A Williamson, Andrew C Warden, John G Oakeshott, Matthew C Taylor, Paul K Crellin, Colin J Jackson, Ralf B Schitten

Inhalable Dry Powder of Bedaquiline for Pulmonary Tuberculosis: In Vitro Physicochemical Characterization, Antimicrobial Activity and Safety Studies

贝达喹啉吸入性干粉治疗肺结核:体外理化特性、抗菌活性及安全性研究

Mohammad A M Momin, Bhamini Rangnekar, Shubhra Sinha, Chen-Yi Cheung, Gregory M Cook, Shyamal C Das

Microtiter Screening Reveals Oxygen-Dependent Antimicrobial Activity of Natural Products Against Mastitis-Causing Bacteria

微量滴定筛选揭示天然产物对引起乳腺炎的细菌具有氧依赖性抗菌活性

Scott A Ferguson, Ayana Menorca, Essie M Van Zuylen, Chen-Yi Cheung, Michelle A McConnell, David Rennison, Margaret A Brimble, Kip Bodle, Scott McDougall, Gregory M Cook, Adam Heikal