日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells

稳定同位素辅助非靶向代谢组学鉴定肺癌细胞中 ALDH1A1 驱动的赤藓糖酸积累

Jie Zhang, Mark A Keibler, Wentao Dong, Jenny Ghelfi, Thekla Cordes, Tamara Kanashova, Arnaud Pailot, Carole L Linster, Gunnar Dittmar, Christian M Metallo, Tim Lautenschlaeger, Karsten Hiller, Gregory Stephanopoulos

Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth

质子输出使细胞内 pH 值碱化,并重新编程碳代谢以驱动正常和恶性细胞生长

Cheuk Him Man, Francois E Mercier, Nian Liu, Wentao Dong, Gregory Stephanopoulos, Li Jiang, Yookyung Jung, Charles P Lin, Anskar Y H Leung, David T Scadden

Removal of lycopene substrate inhibition enables high carotenoid productivity in Yarrowia lipolytica

消除番茄红素底物抑制可使解脂耶氏酵母获得较高的类胡萝卜素产量

Yongshuo Ma, Nian Liu, Per Greisen, Jingbo Li, Kangjian Qiao, Sanwen Huang, Gregory Stephanopoulos

Engineered yeast tolerance enables efficient production from toxified lignocellulosic feedstocks

工程酵母耐受性使有毒木质纤维素原料能够高效生产

Felix H Lam, Burcu Turanlı-Yıldız, Dany Liu, Michael G Resch, Gerald R Fink, Gregory Stephanopoulos

Differential substrate use in EGF- and oncogenic KRAS-stimulated human mammary epithelial cells

EGF 和致癌 KRAS 刺激的人类乳腺上皮细胞中的差异底物使用

Mark A Keibler, Wentao Dong, Keegan D Korthauer, Aaron M Hosios, Sun Jin Moon, Lucas B Sullivan, Nian Liu, Keene L Abbott, Orlando D Arevalo, Kailing Ho, Jennifer Lee, Aasavari S Phanse, Joanne K Kelleher, Othon Iliopoulos, Jonathan L Coloff, Matthew G Vander Heiden, Gregory Stephanopoulos

Synthesis of high-titer alka(e)nes in Yarrowia lipolytica is enabled by a discovered mechanism

通过发现的机制实现解脂耶氏酵母中高滴度烷烃的合成

Jingbo Li, Yongshuo Ma, Nian Liu, Bekir E Eser, Zheng Guo, Peter Ruhdal Jensen, Gregory Stephanopoulos

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

胰腺肿瘤中癌细胞自主细胞外蛋白质分解代谢的直接证据

Shawn M Davidson, Oliver Jonas, Mark A Keibler, Han Wei Hou, Alba Luengo, Jared R Mayers, Jeffrey Wyckoff, Amanda M Del Rosario, Matthew Whitman, Christopher R Chin, Kendall J Condon, Alex Lammers, Katherine A Kellersberger, Brian K Stall, Gregory Stephanopoulos, Dafna Bar-Sagi, Jongyoon Han, Joshua

Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers

谷氨酰胺酶和聚(ADP-核糖)聚合酶抑制剂可抑制嘧啶合成和 VHL 缺陷型肾癌

Arimichi Okazaki, Paulo A Gameiro, Danos Christodoulou, Laura Laviollette, Meike Schneider, Frances Chaves, Anat Stemmer-Rachamimov, Stephanie A Yazinski, Richard Lee, Gregory Stephanopoulos, Lee Zou, Othon Iliopoulos

Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells

Akt调控糖酵解介导上皮细胞的生物能量稳定性

Yin P Hung # ,Carolyn Teragawa # ,Nont Kosaisawe ,Taryn E Gillies ,Michael Pargett ,Marta Minguet ,Kevin Distor ,Briana L Rocha-Gregg ,Jonathan L Coloff ,Mark A Keibler ,Gregory Stephanopoulos ,Gary Yellen ,Joan S Brugge ,John G Albeck

Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation

默克尔细胞多瘤病毒小 T 抗原促进转化所需的促糖酵解代谢扰动

Christian Berrios, Megha Padi, Mark A Keibler, Donglim Esther Park, Vadim Molla, Jingwei Cheng, Soo Mi Lee, Gregory Stephanopoulos, John Quackenbush, James A DeCaprio