Greka相关文献与解析，生知库 | 链接生命科学的每一步

Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway

TMED9 寡聚化和早期分泌途径中错误折叠蛋白质货物捕获的分子基础

Le Xiao, Xiong Pi, Alissa C Goss, Tarick El-Baba, Julian F Ehrmann, Elizabeth Grinkevich, Silvana Bazua-Valenti, Valeria Padovano, Seth L Alper, Dominique Carey, Namrata D Udeshi, Steven A Carr, Juan Lorenzo Pablo, Carol V Robinson, Anna Greka, Hao Wu

信号转导

Protective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury

肾脏TREM2高表达巨噬细胞在肥胖和糖尿病引起的肾损伤中发挥保护作用

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2024.114253

Ayshwarya Subramanian ，Katherine A Vernon ，Yiming Zhou ，Jamie L Marshall ，Maria Alimova ，Carlos Arevalo ，Fan Zhang ，Michal Slyper ，Julia Waldman ，Monica S Montesinos ，Danielle Dionne ，Lan T Nguyen ，Michael S Cuoco ，Dan Dubinsky ，Jason Purnell ，Keith Keller ，Samuel H Sturner ，Elizabeth Grinkevich ，Ayan Ghoshal ，Amanda Kotek ，Giorgio Trivioli ，Nathan Richoz ，Mary B Humphrey ，Isabella G Darby ，Sarah J Miller ，Yingping Xu ，Astrid Weins ，Alexandra Chloe-Villani ，Steven L Chang ，Matthias Kretzler ，Orit Rosenblatt-Rosen ，Jillian L Shaw ，Kurt A Zimmerman ，Menna R Clatworthy ，Aviv Regev ，Anna Greka

FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses

FAF2 是过氧化物酶体稳态和饱和脂质反应的双功能调节剂

期刊:

影响因子:

doi:10.1101/2024.12.12.628015

Choah Kim, Katlyn R Gabriel, Dylan Boone, Matthew R Brown, Katherine Oppenheimer, Maria Kost-Alimova, Juan Lorenzo B Pablo, Anna Greka

发表日期：2024

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N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer's disease mouse model

N-乙酰神经氨酸与饮食诱导的肥胖阿尔茨海默病小鼠模型中的免疫耗竭和记忆力减退加速有关

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-023-36759-8

Stefano Suzzi # ，Tommaso Croese # ，Adi Ravid ，Or Gold ，Abbe R Clark ，Sedi Medina ，Daniel Kitsberg ，Miriam Adam ，Katherine A Vernon ，Eva Kohnert ，Inbar Shapira ，Sergey Malitsky ，Maxim Itkin ，Alexander Brandis ，Tevie Mehlman ，Tomer M Salame ，Sarah P Colaiuta ，Liora Cahalon ，Michal Slyper ，Anna Greka ，Naomi Habib ，Michal Schwartz

Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolution

在单细胞分辨率下揭示黏着斑和干扰素-γ在肾脏同种异体移植细胞排斥反应中的新作用

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2023.1139358

Halawi, Ahmad; El Kurdi, Abdullah B; Vernon, Katherine A; Solhjou, Zhabiz; Choi, John Y; Saad, Anis J; Younis, Nour K; Elfekih, Rania; Mohammed, Mostafa Tawfeek; Deban, Christa A; Weins, Astrid; Abdi, Reza; Riella, Leonardo V; De Serres, Sasha A; Cravedi, Paolo; Greka, Anna; Khoueiry, Pierre; Azzi, Jamil R

Single-Cell Transcriptomics Reveal Disrupted Kidney Filter Cell-Cell Interactions after Early and Selective Podocyte Injury

单细胞转录组学揭示早期和选择性足细胞损伤后肾脏过滤器细胞间相互作用中断

期刊:American Journal of Pathology

影响因子:4.7

doi:10.1016/j.ajpath.2021.11.004

Abbe R Clark, Jamie Marshall, Yiming Zhou, Monica S Montesinos, Haiqi Chen, Lan Nguyen, Fei Chen, Anna Greka

Further Exploration of the Benzimidazole Scaffold as TRPC5 Inhibitors: Identification of 1-Alkyl-2-(pyrrolidin-1-yl)-1H-benzo[d]imidazoles as Potent and Selective Inhibitors.

进一步探索苯并咪唑骨架作为 TRPC5 抑制剂：鉴定 1-烷基-2-(吡咯烷-1-基)-1H-苯并[d]咪唑作为强效选择性抑制剂

期刊:ChemMedChem

影响因子:3.4

doi:10.1002/cmdc.202200151

Sharma Swagat, L Pablo Juan, Tolentino Kirsten T, Gallegos Wacey, Hinman Jennifer, Beninato Madison, Asche MacKenzie, Greka Anna, Hopkins Corey R

骨科研究

发表日期：2022

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Gasdermin D pore structure reveals preferential release of mature interleukin-1

Gasdermin D 的孔结构揭示了成熟白细胞介素-1 的优先释放

期刊:Nature

影响因子:50.5

doi:10.1038/s41586-021-03478-3

Shiyu Xia,Zhibin Zhang,Venkat Giri Magupalli,Juan Lorenzo Pablo,Ying Dong,Setu M Vora,Longfei Wang,Tian-Min Fu,Matthew P Jacobson,Anna Greka,Judy Lieberman,Jianbin Ruan,Hao Wu

Ann Chahroudi receives the 2025 ASCI/Marian W. Ropes, MD, Award

安·查鲁迪荣获2025年ASCI/玛丽安·W·罗普斯医学博士奖

FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses.

FAF2 是过氧化物酶体稳态和饱和脂质反应的双功能调节因子

Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway

TMED9 寡聚化和早期分泌途径中错误折叠蛋白质货物捕获的分子基础

Protective role for kidney TREM2high macrophages in obesity- and diabetes-induced kidney injury

肾脏TREM2高表达巨噬细胞在肥胖和糖尿病引起的肾损伤中发挥保护作用

FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses

FAF2 是过氧化物酶体稳态和饱和脂质反应的双功能调节剂

N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer's disease mouse model

N-乙酰神经氨酸与饮食诱导的肥胖阿尔茨海默病小鼠模型中的免疫耗竭和记忆力减退加速有关

Uncovering a novel role of focal adhesion and interferon-gamma in cellular rejection of kidney allografts at single cell resolution

在单细胞分辨率下揭示黏着斑和干扰素-γ在肾脏同种异体移植细胞排斥反应中的新作用

Single-Cell Transcriptomics Reveal Disrupted Kidney Filter Cell-Cell Interactions after Early and Selective Podocyte Injury

单细胞转录组学揭示早期和选择性足细胞损伤后肾脏过滤器细胞间相互作用中断

Further Exploration of the Benzimidazole Scaffold as TRPC5 Inhibitors: Identification of 1-Alkyl-2-(pyrrolidin-1-yl)-1H-benzo[d]imidazoles as Potent and Selective Inhibitors.

进一步探索苯并咪唑骨架作为 TRPC5 抑制剂：鉴定 1-烷基-2-(吡咯烷-1-基)-1H-苯并[d]咪唑作为强效选择性抑制剂

Gasdermin D pore structure reveals preferential release of mature interleukin-1

Gasdermin D 的孔结构揭示了成熟白细胞介素-1 的优先释放