日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Absorption, Metabolism, Distribution and Excretion (ADME) and Absolute Bioavailability Assessment of Zongertinib in Healthy Male Volunteers

宗格替尼在健康男性志愿者中的吸收、代谢、分布和排泄(ADME)及绝对生物利用度评估

Grempler, Rolf; Joseph, David; Gan, Guanfa; Auclair, Adam M; Tiessen, Renger G; Maw, Hlaing H; Laux, Ralf; Wind, Sven; Roessner, Philipp M; Sadrolhefazi, Behbood; Müller, Fabian; Minich, David

Relative Bioavailability of Zongertinib, an Orally Administered HER2-Selective Tyrosine Kinase Inhibitor, under Fed and Fasted Conditions in Healthy Male Participants: Results from Two Randomized, Open-Label, Crossover Studies

在健康男性受试者中,口服HER2选择性酪氨酸激酶抑制剂Zongertinib在空腹和进食状态下的相对生物利用度:两项随机、开放标签、交叉研究的结果

Pereira, Hélène; Wölke, Stefan; Sadrolhefazi, Behbood; Esmaeili, Habib; Wind, Sven; Gan, Guanfa; Müller, Fabian; Minich, David; Bader, Kerstin; Grempler, Rolf; Law, Yeuk Ki; Roessner, Philipp M

The effect of carbamazepine, a strong CYP3A inducer, on the pharmacokinetics of zongertinib in healthy male volunteers

卡马西平(一种强效CYP3A诱导剂)对健康男性志愿者体内宗格替尼药代动力学的影响

Tian, Xiaofan; Esmaeili, Habib; Minich, David; Seitz, Friedeborg; Roessner, Philipp M; Wind, Sven; Grempler, Rolf; Gan, Guanfa; Chan, Tom S; Mahmoudi, Mazyar; Sadrolhefazi, Behbood; Müller, Fabian

Discovery and Characterization of Brigimadlin, a Novel and Highly Potent MDM2-p53 Antagonist Suitable for Intermittent Dose Schedules

发现并鉴定出一种新型高效 MDM2-p53 拮抗剂 Brigimadlin,该药适用于间歇给药方案

Andreas Gollner #, Dorothea Rudolph #, Ulrike Weyer-Czernilofsky, Rosa Baumgartinger, Peter Jung, Harald Weinstabl, Jürgen Ramharter, Rolf Grempler, Jens Quant, Jörg Rinnenthal, Alejandro Pérez Pitarch, Bojana Golubovic, Daniel Gerlach, Gerd Bader, Kristiane Wetzel, Sebastian Otto, Christian Mandl, 

JS07.4.A A PHASE 0/IA STUDY OF BRIGIMADLIN CONCENTRATION IN BRAIN TISSUE AND A DOSE ESCALATION STUDY OF BRIGIMADLIN PLUS RADIOTHERAPY IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA

JS07.4.AA 0/IA期研究:布瑞吉马德林在脑组织中的浓度及布瑞吉马德林联合放射疗法治疗新诊断胶质母细胞瘤患者的剂量递增研究

Kumar, Mahesh; Brewer, Benjamin; Ali, Farwa; Clark, Heather M; Stierwalt, Julie; Stephens, Yehkyoung C; Savica, Rodolfo; Dickson, Dennis W; Whitwell, Jennifer L; Josephs, Keith A; Hanft, S; Elder, B; Giglio, P; Wu, S H; Farrell, C; Alnahhas, I; Lee, I Y; Walbert, T; Boockvar, J; Vojnic, M; Zacharia, B; Aregawi, D; Kim, L; Schulder, M; Ghatan, S; Singer, S; Silva Correia, C E; Ramakrishna, R; Wu, J; Jeyapalan, S; Magge, R; Patel, N; Agarwal, V; Bhatia, A; Brennan, C; Evans, L; Gill, B; Sengupta, S; Wong, E T; Amankulor, N; Quinones-Hinojosa, A; Neese, L; Scott, C; Perez-Olle, R; Andrews, D; Sarkaria, J N; Mrugala, M M; Jaeckle, K A; Burns, T C; Vaubel, R A; Parney, I F; Chaichana, K L; Clement, P M; Martínez-García, M; Sepúlveda Sanchez, J M; Omuro, A; Pronk, L; Ross, H; Teufel, M; Hesse, R; Grempler, R; Galanis, E

89Zr-immuno-PET using the anti-LAG-3 tracer [89Zr]Zr-BI 754111: demonstrating target specific binding in NSCLC and HNSCC

使用抗 LAG-3 示踪剂 [89Zr]Zr-BI 754111 的 89Zr-免疫-PET:展示 NSCLC 和 HNSCC 中的靶标特异性结合

Iris H C Miedema, Marc C Huisman, Gerben J C Zwezerijnen, Rolf Grempler, Alejandro Perez Pitarch, Andrea Thiele, Raphael Hesse, Mabrouk Elgadi, Alexander Peltzer, Danielle J Vugts, Guus A M S van Dongen, Tanja D de Gruijl, C Willemien Menke-van der Houven van Oordt, Idris Bahce

Trends in industrialization of biotherapeutics: a survey of product characteristics of 89 antibody-based biotherapeutics

生物治疗药物产业化趋势:89种抗体生物治疗药物产品特性调查

Martin, Kyle P; Grimaldi, Christine; Grempler, Rolf; Hansel, Steven; Kumar, Sandeep

Design and rationale of the EMPA-VISION trial: investigating the metabolic effects of empagliflozin in patients with heart failure

EMPA-VISION试验的设计和原理:研究恩格列净对心力衰竭患者的代谢影响

Hundertmark, Moritz J; Agbaje, Olorunsola F; Coleman, Ruth; George, Jyothis T; Grempler, Rolf; Holman, Rury R; Lamlum, Hanan; Lee, Jisoo; Milton, Joanne E; Niessen, Heiko G; Rider, Oliver; Rodgers, Christopher T; Valkovič, Ladislav; Wicks, Eleanor; Mahmod, Masliza; Neubauer, Stefan

Characterization of Micro-RNA Changes during the Progression of Type 2 Diabetes in Zucker Diabetic Fatty Rats

Zucker糖尿病肥胖大鼠2型糖尿病进展过程中microRNA变化的特征分析

Delic, Denis; Eisele, Claudia; Schmid, Ramona; Luippold, Gerd; Mayoux, Eric; Grempler, Rolf

Short- and Longterm Glycemic Control of Streptozotocin-Induced Diabetic Rats Using Different Insulin Preparations

使用不同胰岛素制剂对链脲佐菌素诱导糖尿病大鼠进行短期和长期血糖控制的研究

Luippold, Gerd; Bedenik, Jessica; Voigt, Anke; Grempler, Rolf