日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Translational molecular imaging and drug development in multiple sclerosis

多发性硬化症的转化分子影像和药物开发

Tay, Daniel; Ahmed, Hazem; Dawoud, Alyaa; Salam, Mohamed; Gobbi, Luca; Grether, Uwe; Edelmann, Martin R; Wittwer, Matthias B; Collin, Ludovic; Atz, Kenneth; Keaney, James; Giroud, Maude; Rossi, Alexia; Gennari, Antonio Giulio; Pagano, Gennaro; Parrot, Neil John; Barakovic, Muhamed; Rominger, Axel; Gebhard, Catherine; Ametamey, Simon M; Saindane, Amit M; Liang, Steven H; Haider, Achi

Single-position ligand modifications tune CB(2)R activity by targeting the toggle switch

通过靶向开关,单点配体修饰可以调节 CB(2)R 的活性。

Ganzoni, Rudolf L Z; Kosar, Miroslav; Han, Yongqi; Vitale, Rosa Maria; Amodeo, Pietro; Li, Xiaoting; Zha, Zhonghua; Patej, Kacper J; Kicin, Bilal; Strunden, Taddäus E N; Reichert, Lisa; Gómez-Bouzó, Uxía; Perera, Themiya P; Atz, Kenneth; Guba, Wolfgang; Bartelmus, Christian; Bigler, Raphael; Tosatti, Paolo; Bachmann, Stephan; Hua, Tian; Sykes, David A; Veprintsev, Dmitry B; Grether, Uwe; Carreira, Erick M

The Parkinson's Disease Drug Tolcapone and Analogues are Potent Glycomimetic Lectin Inhibitors of Pseudomonas aeruginosa LecA

帕金森病药物托卡朋及其类似物是铜绿假单胞菌LecA的强效糖模拟凝集素抑制剂。

Leusmann, Steffen; Siebs, Eike; Kuhaudomlarp, Sakonwan; Varrot, Annabelle; Imberty, Anne; Kuhn, Bernd; Lerner, Christian; Grether, Uwe; Titz, Alexander

A Highly Selective and Versatile Probe Platform for Visualization of Monoacylglycerol Lipase

一种用于可视化单酰甘油脂肪酶的高选择性和多功能探针平台

Hentsch, Axel; Guberman, Mónica; Radetzki, Silke; Kaushik, Sofia; Huizenga, Mirjam; Paul, Jerome; Schippers, Maria; Benz, Jörg; Kuhn, Bernd; Heer, Dominik; Topp, Andreas; Esteves Gloria, Ludivine; Walter, Alexander; Hochstrasser, Remo; Wittwer, Matthias B; von Kries, Jens Peter; Collin, Ludovic; Blaising, Julie; van der Stelt, Mario; Lipstein, Noa; Grether, Uwe; Nazaré, Marc

Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-dimensional optimization

通过反应预测和多维优化加速药物发现中的先导化合物转化进程

Nippa, David F; Atz, Kenneth; Stenzhorn, Yannick; Müller, Alex T; Tosstorff, Andreas; Benz, Jörg; Binch, Hayley; Bürkler, Markus; Haider, Achi; Heer, Dominik; Hochstrasser, Remo; Kramer, Christian; Reutlinger, Michael; Schneider, Petra; Shema, Thierry; Topp, Andreas; Walter, Alexander; Wittwer, Matthias B; Wolfard, Jens; Kuhn, Bernd; van der Stelt, Mario; Martin, Rainer E; Grether, Uwe; Schneider, Gisbert

Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research

高特异性微型荧光单酰甘油脂肪酶探针助力转化研究

Hentsch, Axel; Guberman, Mónica; Radetzki, Silke; Kaushik, Sofia; Huizenga, Mirjam; He, Yingfang; Contzen, Jörg; Kuhn, Bernd; Benz, Jörg; Schippers, Maria; Paul, Jerome; Leibrock, Lea; Collin, Ludovic; Wittwer, Matthias; Topp, Andreas; O'Hara, Fionn; Heer, Dominik; Hochstrasser, Remo; Blaising, Julie; von Kries, Jens P; Mu, Linjing; van der Stelt, Mario; Mergenthaler, Philipp; Lipstein, Noa; Grether, Uwe; Nazaré, Marc

Relevance of a peripheral site of action outside the brain-blood barrier for the beneficial effects of CB(2) receptor activation in experimental ALS in male mice

脑血屏障外外周作用位点与CB(2)受体激活在雄性小鼠实验性ALS中的有益作用的相关性

Gómez-Almería, Marta; Gonzalo-Consuegra, Claudia; Rodríguez-Cueto, Carmen; Cabañas-Cotillas, María; Jiménez-Amor, Alberto; Machín-Díaz, Isabel; Wittwer, Matthias B; Dzygiel, Pawel; Clemente, Diego; Grether, Uwe; Fernández-Ruiz, Javier; de Lago, Eva

Exploration of (R)-[(11)C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates

探索(R)-[(11)C]YH168作为PET示踪剂在脑内单酰甘油脂肪酶成像中的应用:从小鼠到非人灵长类动物

He, Yingfang; Zheng, MingQiang; Gu, Jiwei; Reichert, Lisa; Trimborn, Johannes; Zhang, Hui; Keller, Claudia; Crosby, Mallory; Collin, Ludovic; Heer, Dominik; Pavlovic, Anto; Topp, Andreas; Wittwer, Matthias Beat; Grether, Uwe; Gobbi, Luca; Schibli, Roger; Huang, Yiyun; Mu, Linjing

Bioprocess exploitation of microaerobic auto-induction using the example of rhamnolipid biosynthesis in Pseudomonas putida KT2440.

利用假单胞菌 KT2440 中鼠李糖脂的生物合成来研究微需氧自诱导的生物工艺。

Grether Jakob, Dittmann Holger, Willems Leon, Schmiegelt Tabea, Benatto Perino Elvio Henrique, Hubel Philipp, Lilge Lars, Hausmann Rudolf

CellEKT: A Robust Chemical Proteomics Workflow to Profile Cellular Target Engagement of Kinase Inhibitors.

CellEKT:一种稳健的化学蛋白质组学工作流程,用于分析激酶抑制剂的细胞靶标结合情况

Rüegger Joel, Gagestein Berend, Janssen Antonius P A, Valeanu Alexandra, Mori Alger Lazo, van der Peet Marielle, Boutkan Michael S, Florea Bogdan I, Henneman Alex A, Hochstrasser Remo, Wang Haiyan, Westwood Paul, Topp Andreas, Gomez Barila Patricia M, Medema Jan Paul, Jimenez Connie R, Woersdoerfer Bigna, Kirchner Stephan, Zhang Jitao David, Grether Uwe, Rufer Arne C, van der Stelt Mario