日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Stalling the Enemy: Targeting Nsp13 for Next-Generation SARS-CoV-2 Antivirals

阻击敌人:以 Nsp13 为靶点开发下一代 SARS-CoV-2 抗病毒药物

Castro, Jose M; Slack, Ryan L; Ong, Yee T; Zhang, Huanchun; Gifford, Levi B; Courouble, Valentine V; Aiken, Riley M; Shankar, Vishal; O'Leary, Timothy R; Griffin, Patrick R; Lan, Shuiyun; Du, Yuhong; Fu, Haian; Sarafianos, Stefan G

PAR-Driven Condensation Maintains Stalled Replication Fork Stability

PAR驱动的冷凝维持停滞复制叉的稳定性

Zhang, Lei; Zhang, Zeyu; O'Leary, Timothy R; Shwartz, Arkadi; Kao, Guoyun; Griffin, Patrick R; Zhang, Yong

Human RIG-I Antiviral Deficiency Caused by a Dominant-Negative Variant Locked in a Signaling-Inactive State

人类RIG-I抗病毒缺陷是由一种处于信号传导失活状态的显性负性变异引起的

Solotchi, Mihai; Jing, Huie; Gebauer, Emma; Novick, Scott J; Pascal, Bruce D; Tung, Wesley; Hanpude, Pranita; Madura, Talia; Zhang, Yu; Alba, Camille; Saracino, Annalisa; Laghetti, Paola; Shaw, Elana R; Rosen, Lindsey B; Holland, Steven M; Lisco, Andrea; Dalgard, Clifton L; Marcotrigiano, Joseph; Griffin, Patrick R; Su, Helen C; Patel, Smita S

Development of clinically viable non-muscle myosin II small molecule inhibitors.

开发具有临床应用价值的非肌肉肌球蛋白 II 小分子抑制剂

Radnai Laszlo, Young Erica J, Kikuti Carlos, Toth Katalin, Zhou Minghai, Hafenbreidel Madalyn, Stremel Rebecca F, Lin Li, Pasetto Paolo, Jin Xiaomin, Patel Aagam, Conlon Michael, Briggs Sherri B, Heidsieck Leïla, Sweeney H Lee, Sellers James, Krieger-Burke Teresa, Martin William H, Sisco Jay, Young Steven, Pearson Paul, Rumbaugh Gavin, Araldi Gian Luca, Duddy Steven K, Cameron Michael D, Surman Matthew, Houdusse Anne, Griffin Patrick R, Kamenecka Theodore M, Miller Courtney A

Structural proteomics defines a sequential priming mechanism for the progesterone receptor

结构蛋白质组学揭示了孕激素受体的顺序启动机制

Mann, Matthew D; Wang, Min; Ferreon, Josephine C; Tsoi, Phoebe S; Suess, Michael P; Jain, Antrix; Malovannaya, Anna; Alvarez, Roberto Vera; Pascal, Bruce D; Kumar, Raj; Edwards, Dean P; Griffin, Patrick R

A ternary switch model governing ERα ligand binding domain conformation

控制ERα配体结合域构象的三元开关模型

McDougal, Daniel P; Pederick, Jordan L; Novick, Scott J; Jovcevski, Blagojce; Warrender, Annmaree K; Pascal, Bruce D; Griffin, Patrick R; Bruning, John B

Structural determinants of non-covalent PPARγ inverse agonism and their therapeutic implications.

非共价 PPARγ 反向激动作用的结构决定因素及其治疗意义。

Kuo Kuang-Ting, Bdiri Bilel, He Yuanjun, Garcia-Ordonez Ruben D, McDougal Daniel P, Ruiz Claudia, Chang Mi Ra, Cameron Michael D, Bruning John B, Kamenecka Theodore M, Griffin Patrick R

Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation

靶向选择性PCK1和PGC-1α赖氨酸乙酰化的小分子通过增加乳酸氧化发挥抗糖尿病作用。

Mutlu, Beste; Sharabi, Kfir; Sohn, Jee Hyung; Yuan, Bo; Latorre-Muro, Pedro; Qin, Xin; Yook, Jin-Seon; Lin, Hua; Yu, Deyang; Camporez, João Paulo G; Kajimura, Shingo; Shulman, Gerald I; Hui, Sheng; Kamenecka, Theodore M; Griffin, Patrick R; Puigserver, Pere

Nucleosome Engagement Regulates RORγt Structure and Dynamics.

核小体结合调节 RORγt 结构和动态

Strutzenberg Timothy S, Mann Matthew D, Li Xiandu, Shin Hyejeong, Kelsey Jordan, Aiyer Sriram, Yu Jingting, Gray Gennavieve, Zhang Zeyuan, Shan Zelin, Zhou Bo, Zheng Ye, Griffin Patrick R, Lyumkis Dmitry

Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation.

靶向选择性 PCK1 和 PGC-1α 赖氨酸乙酰化的小分子通过增加乳酸氧化发挥抗糖尿病作用

Mutlu Beste, Sharabi Kfir, Sohn Jee Hyung, Yuan Bo, Latorre-Muro Pedro, Qin Xin, Yook Jin-Seon, Lin Hua, Yu Deyang, Camporez João Paulo G, Kajimura Shingo, Shulman Gerald I, Hui Sheng, Kamenecka Theodore M, Griffin Patrick R, Puigserver Pere