日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dosing Colistimethate Every 8 h Results in Higher Plasma Concentrations of Active Colistin Than Every 12-Hourly Dosing without Increase in Nephrotoxicity: A Phase 1 Pharmacokinetics Trial in Healthy Adult Volunteers

一项针对健康成年志愿者的 1 期药代动力学试验表明,每 8 小时给予一次粘菌素甲酯可使血浆中活性粘菌素浓度高于每 12 小时给予一次,且不会增加肾毒性。

Yendewa, George A; Griffiss, John McLeod; Gray, Wesley A; Healen, Amanda; Proskin, Howard M; Fulton, Scott A; O'Riordan, Mary Ann; Hoppel, Charles; Blumer, Jeffrey L; Salata, Robert A

A two-part phase 1 study to establish and compare the safety and local tolerability of two nasal formulations of XF-73 for decolonisation of Staphylococcus aureus: A previously investigated 0.5mg/g viscosified gel formulation versus a modified formulation

一项分为两部分的 I 期研究,旨在确定并比较两种 XF-73 鼻腔制剂用于清除金黄色葡萄球菌的安全性和局部耐受性:一种是先前研究过的 0.5mg/g 粘稠凝胶制剂,另一种是改良制剂。

Yendewa, George A; Griffiss, J McLeod; Jacobs, Michael R; Fulton, Scott A; O'Riordan, Mary Ann; Gray, Wesley A; Proskin, Howard M; Winkle, Peter; Salata, Robert A

Impact of Rifabutin or Rifampin on Bedaquiline Safety, Tolerability, and Pharmacokinetics Assessed in a Randomized Clinical Trial with Healthy Adult Volunteers

利福布汀或利福平对贝达喹啉安全性、耐受性和药代动力学的影响:一项针对健康成年志愿者的随机临床试验

Healan, Amanda M; Griffiss, J McLeod; Proskin, Howard M; O'Riordan, Mary Ann; Gray, Wesley A; Salata, Robert A; Blumer, Jeffrey L

Mycobactericidal activity of bedaquiline plus rifabutin or rifampin in ex vivo whole blood cultures of healthy volunteers: A randomized controlled trial

贝达喹啉联合利福布汀或利福平在健康志愿者离体全血培养物中的杀分枝杆菌活性:一项随机对照试验

Wallis, Robert S; Good, Caryn E; O'Riordan, Mary A; Blumer, Jeffrey L; Jacobs, Michael R; Griffiss, J McLeod; Healan, Amanda; Salata, Robert A

Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study

在一项 1 期研究中,评估了 CRS3123(一种用于治疗艰难梭菌感染的甲硫氨酰-tRNA 合成酶抑制剂)的安全性、耐受性、全身暴露量和代谢情况。

Nayak, Seema U; Griffiss, J McLeod; Blumer, Jeffrey; O'Riordan, Mary Ann; Gray, Wesley; McKenzie, Robin; Jurao, Robert A; An, Amanda T; Le, Melissa; Bell, Stacie J; Ochsner, Urs A; Jarvis, Thale C; Janjic, Nebojsa; Zenilman, Jonathan M

A response adaptive randomization platform trial for efficient evaluation of Ebola virus treatments: A model for pandemic response

一种用于高效评估埃博拉病毒治疗方案的响应自适应随机化平台试验:一种应对大流行的模型

Berry, Scott M; Petzold, Elizabeth A; Dull, Peter; Thielman, Nathan M; Cunningham, Coleen K; Corey, G Ralph; McClain, Micah T; Hoover, David L; Russell, James; Griffiss, J McLeod; Woods, Christopher W

Safety and pharmacokinetics of XOMA 3AB, a novel mixture of three monoclonal antibodies against botulinum toxin A

XOMA 3AB(一种新型的抗A型肉毒杆菌毒素单克隆抗体混合物)的安全性和药代动力学研究

Nayak, S U; Griffiss, J M; McKenzie, R; Fuchs, E J; Jurao, R A; An, A T; Ahene, A; Tomic, M; Hendrix, C W; Zenilman, J M

Stability of colistimethate sodium in aqueous solution

粘菌素甲磺酸钠在水溶液中的稳定性

Healan, A M; Gray, W; Fuchs, E J; Griffiss, J M; Salata, R A; Blumer, J

Lack of lipid A pyrophosphorylation and functional lptA reduces inflammation by Neisseria commensals

脂质A焦磷酸化和功能性lptA的缺乏会降低奈瑟菌共生菌引起的炎症。

John, Constance M; Liu, Mingfeng; Phillips, Nancy J; Yang, Zhijie; Funk, Courtney R; Zimmerman, Lindsey I; Griffiss, J McLeod; Stein, Daniel C; Jarvis, Gary A

Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure

预防地方性脑膜炎球菌病的人类脂寡糖IGG可识别内部乳糖-N-新四糖结构

Hui Cheng, Zhijie Yang, Michele M Estabrook, Constance M John, Gary A Jarvis, Stephanie McLaughlin, J McLeod Griffiss