日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9

ATX968 的发现:一种口服有效的 DHX9 变构抑制剂

Daniels, Matthew H; Castro, Jennifer; Lee, Young-Tae; Gotur, Deepali; Knockenhauer, Kevin E; Grigoriu, Simina; Lockbaum, Gordon J; Cheong, Jae Eun; Lu, Chuang; Brennan, David; Buker, Shane M; Liu, Julie; Yao, Shihua; Sparling, Brian A; Sickmier, E Allen; Ribich, Scott; Blakemore, Steve J; Silver, Serena J; Boriack-Sjodin, P Ann; Duncan, Kenneth W; Copeland, Robert A

Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.

核糖核酸外切酶 XRN1 作为癌症靶点的特性分析以及腺苷-3',5'-二磷酸作为强效酶抑制剂的鉴定

Lockbaum Gordon J, Lynes Maureen M, Shen Sophie A, Liu Julie, Holt Nicholas, Nayak Sunaina P, Knockenhauer Kevin E, Yao Shihua, Sickmier E Allen, Raman Anugraha, Wu Jie, Case April, Shehaj Livia, Buker Shane M, Grigoriu Simina, Ribich Scott, Blakemore Stephen J, Sparling Brian A, Duncan Kenneth W, Copeland Robert A, Silver Serena J, Boriack-Sjodin P Ann

Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement

发现驱动蛋白KIF18A抑制剂ATX020:硅原子取代的战术应用

Sparling, Brian A; Lee, Hyelee; Zablocki, Mary-Margaret; Lynes, Maureen M; Grigoriu, Simina; Shehaj, Livia; Lockbaum, Gordon J; Khan, Sanjoy K; Hotz, Taylor; Lee, Young-Tae; Buker, Shane M; Gotur, Deepali; Lu, Chuang; Ribich, Scott; Blakemore, Stephen J; Boriack-Sjodin, P Ann; Silver, Serena J; Copeland, Robert A; Duncan, Kenneth W

Crystal structures of the DExH-box RNA helicase DHX9

DExH盒RNA解旋酶DHX9的晶体结构

Lee, Young Tae; Sickmier, E Allen; Grigoriu, Simina; Castro, Jennifer; Boriack-Sjodin, P Ann

The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin

RCAN1:CN复合物的结构解释了钙调磷酸酶对底物的抑制和募集作用

Li, Yang; Sheftic, Sarah R; Grigoriu, Simina; Schwieters, Charles D; Page, Rebecca; Peti, Wolfgang

Covalently circularized nanodiscs for studying membrane proteins and viral entry

用于研究膜蛋白和病毒入侵的共价环化纳米盘

Nasr, Mahmoud L; Baptista, Diego; Strauss, Mike; Sun, Zhen-Yu J; Grigoriu, Simina; Huser, Sonja; Plückthun, Andreas; Hagn, Franz; Walz, Thomas; Hogle, James M; Wagner, Gerhard

Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding

G蛋白α亚基的构象动力学受到核苷酸结合的严格调控

Goricanec, David; Stehle, Ralf; Egloff, Pascal; Grigoriu, Simina; Plückthun, Andreas; Wagner, Gerhard; Hagn, Franz

The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin

钙调磷酸酶底物结合和免疫抑制剂抑制的分子机制

Grigoriu, Simina; Bond, Rachel; Cossio, Pilar; Chen, Jennifer A; Ly, Nina; Hummer, Gerhard; Page, Rebecca; Cyert, Martha S; Peti, Wolfgang

Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD.

大肠杆菌毒素/抗毒素对 MqsR/MqsA 调节毒素 CspD

Kim Younghoon, Wang Xiaoxue, Zhang Xue-Song, Grigoriu Simina, Page Rebecca, Peti Wolfgang, Wood Thomas K