日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

De novo designed protein inhibitors of amyloid aggregation and seeding

从头设计淀粉样蛋白聚集和播种的蛋白质抑制剂

Murray, Kevin A; Hu, Carolyn J; Griner, Sarah L; Pan, Hope; Bowler, Jeannette T; Abskharon, Romany; Rosenberg, Gregory M; Cheng, Xinyi; Seidler, Paul M; Eisenberg, David S

The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical

HIV-1整合酶中保留的HTH对接裂隙具有重要的功能意义

Galilee, Meytal; Britan-Rosich, Elena; Griner, Sarah L; Uysal, Serdar; Baumgärtel, Viola; Lamb, Don C; Kossiakoff, Anthony A; Kotler, Moshe; Stroud, Robert M; Marx, Ailie; Alian, Akram

Development and binding mode assessment of N-[4-[2-propyn-1-yl[(6S)-4,6,7,8-tetrahydro-2-(hydroxymethyl)-4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells.

对靶向肿瘤细胞的新型胸苷酸合成酶抑制剂 N-[4-[2-丙炔-1-基[(6S)-4,6,7,8-四氢-2-(羟甲基)-4-氧代-3H-环戊并[g]喹唑啉-6-基]氨基]苯甲酰基]-l-γ-谷氨酰-D-谷氨酸 (BGC 945) 进行开发和结合模式评估

Tochowicz Anna, Dalziel Sean, Eidam Oliv, O'Connell Joseph D 3rd, Griner Sarah, Finer-Moore Janet S, Stroud Robert M

Fabs enable single particle cryoEM studies of small proteins

Fab片段能够实现对小蛋白的单颗粒冷冻电镜研究。

Wu, Shenping; Avila-Sakar, Agustin; Kim, JungMin; Booth, David S; Greenberg, Charles H; Rossi, Andrea; Liao, Maofu; Li, Xueming; Alian, Akram; Griner, Sarah L; Juge, Narinobu; Yu, Yadong; Mergel, Claudia M; Chaparro-Riggers, Javier; Strop, Pavel; Tampé, Robert; Edwards, Robert H; Stroud, Robert M; Craik, Charles S; Cheng, Yifan

Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome.

RluF-RNA复合物的晶体结构:碱基对重排是RluF对核糖体U2604选择性的关键

Alian Akram, DeGiovanni Andrew, Griner Sarah L, Finer-Moore Janet S, Stroud Robert M