日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Activated ATF6α is a hepatic tumour driver restricting immunosurveillance.

活化的 ATF6α 是肝肿瘤的驱动因子,可限制免疫监视。

Li Xin, Lebeaupin Cynthia, Kadianaki Aikaterini, Druelle-Cedano Clementine, Vesper Niklas, Rennert Charlotte, Huguet-Pradell Júlia, Gomez Ramos Borja, Fan Chaofan, Piecyk Robert Stefan, Zizmare Laimdota, Ramadori Pierluigi, Li Luqing, Frick Lukas, Qiu Menjie, Zhang Cangang, Martins Nascentes Melo Luiza, Ranvir Vikas Prakash, Shen Peng, Hanselmann Johannes, Kosla Jan, Fernández-Vaquero Mirian, Vucur Mihael, Baskaran Praveen, Bao Xuanwen, Coleman Olivia I, Tang Yingyue, Cetin Miray, Chen Zhouji, Jang Insook, Del Prete Stefania, Rahbari Mohammad, Zhang Peng, Pham Timothy V, Hou Yushan, Sun Aihua, Gu Li, Kim Laura C, Rothermel Ulrike, Heide Danijela, Ali Adnan, Gallage Suchira, Talvard-Balland Nana, Piqué-Gili Marta, Gris-Oliver Albert, Bevilacqua Alessio, Schlicker Lisa, Duffey Alec, Unger Kristian, Szydlowska Marta, Hetzer Jenny, Odom Duncan T, Machauer Tim, Bucci Daniele, Sant Pooja, Lee Jun-Hoe, Rösler Jonas, Meckelmann Sven W, Schreck Johannes, Murray Sue, Simon M Celeste, Nahnsen Sven, Schulze Almut, Ho Ping-Chih, Jugold Manfred, Breuhahn Kai, Mallm Jan-Philipp, Schirmacher Peter, Roth Susanne, Rahbari Nuh, Tschaharganeh Darjus F, Roessler Stephanie, Goeppert Benjamin, Bengsch Bertram, Andrieux Geoffroy, Boerries Melanie, Malek Nisar P, Prinz Marco, Weber Achim, Zeiser Robert, Tamayo Pablo, Bronsert Peter, Kurowski Konrad, Thimme Robert, Yuan Detian, Carretero Rafael, Luedde Tom, Pinyol Roser, Hartmann Felix J, Karin Michael, Tasdogan Alpaslan, Trautwein Christoph, Mall Moritz, Hofmann Maike, Llovet Josep M, Haller Dirk, Kaufman Randal J, Heikenwälder Mathias

Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signaling

突变扫描揭示致癌性CTNNB1突变对信号传导具有多种影响

Krishna, Anagha; Meynert, Alison; Dolt, Karamjit Singh; Kelder, Martijn; Mesropian, Agavni; Ewing, Ailith; Brouwers, Conny; Claassens, Jill Wc; Linssen, Margot M; Sheraz, Shahida; Taylor, Gillian Ca; Gautier, Philippe; Ferrer-Vaquer, Anna; Grimes, Graeme; Becher, Hannes; Silk, Ryan; Gris-Oliver, Albert; Pinyol, Roser; Semple, Colin A; Kendall, Timothy J; Bird, Thomas Graham; Hadjantonakis, Anna-Katerina; Marsh, Joseph A; Llovet, Josep M; Hohenstein, Peter; Wood, Andrew J; Ozdemir, Derya D

Effective therapeutic targeting of CTNNB1-mutant hepatoblastoma with WNTinib.

WNTinib 可有效靶向治疗 CTNNB1 突变型肝母细胞瘤。

Balaseviciute Ugne, Huguet-Pradell Júlia, Abril-Fornaguera Jordi, Gris-Oliver Albert, Rialdi Alex, Fernández-Martínez Elisa, Montironi Carla, Del Pozo Vanessa, Houghton Peter, Zanatto Laura, Mesropian Agavni, Keraite Ieva, Thung Swan, Armengol Carolina, Sancho-Bru Pau, Guccione Ernesto, Pinyol Roser, Llovet Josep M

Human-correlated genetic models identify precision therapy for liver cancer

人类相关遗传模型揭示肝癌的精准治疗方案

Miryam Müller ,Stephanie May # ,Holly Hall # ,Timothy J Kendall ,Lynn McGarry ,Lauriane Blukacz ,Sandro Nuciforo ,Anastasia Georgakopoulou ,Thomas Jamieson ,Narisa Phinichkusolchit ,Sandeep Dhayade ,Toshiyasu Suzuki ,Júlia Huguet-Pradell ,Ian R Powley ,Leah Officer-Jones ,Rachel L Pennie ,Roger Esteban-Fabró ,Albert Gris-Oliver ,Roser Pinyol ,George L Skalka ,Jack Leslie ,Matthew Hoare ,Joep Sprangers ,Gaurav Malviya ,Agata Mackintosh ,Emma Johnson ,Misti McCain ,John Halpin ,Christos Kiourtis ,Colin Nixon ,Graeme Clark ,William Clark ,Robin Shaw ,Ann Hedley ,Thomas M Drake ,Ee Hong Tan ,Matt Neilson ,Daniel J Murphy ,David Y Lewis ,Helen L Reeves ,John Le Quesne ,Derek A Mann ,Leo M Carlin ,Karen Blyth ,Josep M Llovet ,Markus H Heim ,Owen J Sansom ,Crispin J Miller ,Thomas G Bird

E7386 Enhances Lenvatinib's Antitumor Activity in Preclinical Models and Human Hepatocellular Carcinoma.

E7386 增强了乐伐替尼在临床前模型和人类肝细胞癌中的抗肿瘤活性。

Mesropian Agavni, Gris-Oliver Albert, Balaseviciute Ugne, Potdar Alka A, Kimura Takayuki, Shen Jialing, Torres-Marcén Martí, Abril-Fornaguera Jordi, Piqué-Gili Marta, Camell-Raventos David, Peix Judit, Fernández-Martínez Elisa, Huguet-Pradell Júlia, Hernández de Sande Ana, Keraite Ieva, Esteban-Fabró Roger, Bárcena-Varela Marina, Lindblad Katherine E, Lujambio Amaia, Guccione Ernesto, Thung Swan, Ikeda Masafumi, Kudo Masatoshi, Sia Daniela, Pinyol Roser, Llovet Josep M

Oncogenic role of PMEPA1 and its association with immune exhaustion and TGF-β activation in HCC

PMEPA1 的致癌作用及其与肝细胞癌中的免疫衰竭和 TGF-β 激活的关系

Marta Piqué-Gili, Carmen Andreu-Oller, Agavni Mesropian, Roger Esteban-Fabró, Marina Bárcena-Varela, Marina Ruiz de Galarreta, Carla Montironi, Iris Martinez-Quetglas, Sarah Cappuyns, Judit Peix, Ieva Keraite, Albert Gris-Oliver, Elisa Fernández-Martínez, Ezequiel Mauro, Miguel Torres-Martin, Jordi

Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance

鉴定出对 WEE1 或 ATR 抑制剂有反应、克服 PARP 抑制剂耐药性的乳腺癌和卵巢癌模型中分子定义的亚群。

Serra, Violeta; Wang, Anderson T; Castroviejo-Bermejo, Marta; Polanska, Urszula M; Palafox, Marta; Herencia-Ropero, Andrea; Jones, Gemma N; Lai, Zhongwu; Armenia, Joshua; Michopoulos, Filippos; Llop-Guevara, Alba; Brough, Rachel; Gulati, Aditi; Pettitt, Stephen J; Bulusu, Krishna C; Nikkilä, Jenni; Wilson, Zena; Hughes, Adina; Wijnhoven, Paul W G; Ahmed, Ambar; Bruna, Alejandra; Gris-Oliver, Albert; Guzman, Marta; Rodríguez, Olga; Grueso, Judit; Arribas, Joaquin; Cortés, Javier; Saura, Cristina; Lau, Alan; Critchlow, Susan; Dougherty, Brian; Caldas, Carlos; Mills, Gordon B; Barrett, J Carl; Forment, Josep V; Cadogan, Elaine; Lord, Christopher J; Cruz, Cristina; Balmaña, Judith; O'Connor, Mark J

TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS-CoV-2 infection

TLR2 和 TLR7 介导针对 SARS-CoV-2 感染的不同免疫病理学和抗病毒浆细胞样树突状细胞反应

Renée M van der Sluis ,Lamin B Cham ,Albert Gris-Oliver # ,Kristine R Gammelgaard # ,Jesper G Pedersen # ,Manja Idorn ,Ulvi Ahmadov ,Sabina Sanches Hernandez ,Ena Cémalovic ,Stine H Godsk ,Jacob Thyrsted ,Jesper D Gunst ,Silke D Nielsen ,Janni J Jørgensen ,Tobias Wang Bjerg ,Anders Laustsen ,Line S Reinert ,David Olagnier ,Rasmus O Bak ,Mads Kjolby ,Christian K Holm ,Martin Tolstrup ,Søren R Paludan ,Lasse S Kristensen ,Ole S Søgaard ,Martin R Jakobsen

AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors

AKT-mTORC1 重新激活是 PTEN 基因缺失的乳腺癌中 PI3Kβ/AKT 抑制剂产生耐药性的主要驱动因素,可通过与 Mcl-1 抑制剂联合使用来克服

Shanade Dunn, Cath Eberlein, Jason Yu, Albert Gris-Oliver, Swee Hoe Ong, Urs Yelland, Natalie Cureton, Anna Staniszewska, Robert McEwen, Millie Fox, James Pilling, Philip Hopcroft, Elizabeth A Coker, Patricia Jaaks, Mathew J Garnett, Beverley Isherwood, Violeta Serra, Barry R Davies, Simon T Barry, 

GDF15 Is an Eribulin Response Biomarker also Required for Survival of DTP Breast Cancer Cells

GDF15 是 Eribulin 反应生物标志物,也是 DTP 乳腺癌细胞存活所必需的

Chiara Bellio, Marta Emperador, Pol Castellano, Albert Gris-Oliver, Francesc Canals, Alex Sánchez-Pla, Esther Zamora, Joaquín Arribas, Cristina Saura, Violeta Serra, Josep Tabernero, Bruce A Littlefield, Josep Villanueva