日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332(gp120) glycan-independent epitope

鉴定出一种针对N332(gp120)糖基非依赖性表位的强效V3糖基位点广谱中和抗体

Gieselmann, Lutz; DeLaitsch, Andrew T; Rohde, Malena; Radford, Caelan; Worczinski, Johanna; Ashurov, Anna; Ahmadov, Elvin; Burger, Judith A; Havenar-Daughton, Colin; Deshpande, Sharvari; Giovannoni, Federico; Corti, Davide; Kreer, Christoph; Ercanoglu, Meryem Seda; Schommers, Philipp; Georgiev, Ivelin S; West, Anthony P Jr; Knüfer, Jacqueline; Stumpf, Ricarda; Kroidl, Arne; Geldmacher, Christof; Maganga, Lucas; William, Wiston; Ntinginya, Nyanda E; Hoelscher, Michael; Yang, Zhengrong; Wei, Qing; Renfrow, Matthew B; Green, Todd J; Novak, Jan; van Gils, Marit J; Gristick, Harry B; Gruell, Henning; Bloom, Jesse D; Seaman, Michael S; Bjorkman, Pamela J; Klein, Florian

Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy.

HIV-1 精英中和抗体队列分析揭示了一种用于 HIV-1 预防和治疗的 CD4 结合位点广谱中和抗体。

Gieselmann Lutz, DeLaitsch Andrew T, Rohde Malena, Gruell Henning, Kreer Christoph, Ercanoglu Meryem Seda, Gristick Harry B, Schommers Philipp, Ahmadov Elvin, Radford Caelan, Mazzolini Andrea, Zhang Lily, West Anthony P Jr, Worczinski Johanna, Momot Anna, Reichwein Maren L, Knüfer Jacqueline, Stumpf Ricarda, Mkhize Nonhlanhla N, Kaldine Haajira, Bhebhe Sinethemba, Deshpande Sharvari, Giovannoni Federico, Stefanutti Erin, Benigni Fabio, Havenar-Daughton Colin, Corti Davide, Kroidl Arne, Adhikari Anurag, Nanfack Aubin J, Ambada Georgia E, Duerr Ralf, Maganga Lucas, William Wiston, Ntinginya Nyanda E, Wolf Timo, Geldmacher Christof, Hoelscher Michael, Lehmann Clara, Moore Penny L, Mora Thierry, Walczak Aleksandra M, Gilbert Peter B, Doria-Rose Nicole A, Huang Yunda, Bloom Jesse D, Seaman Michael S, Bjorkman Pamela J, Klein Florian

Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design

绘制 CD4 结合位点广谱中和抗体中关键体细胞高频突变图谱,有助于 HIV-1 疫苗设计。

Kim-Marie A Dam ,Harry B Gristick ,Yancheng E Li ,Zhi Yang ,Priyanthi N P Gnanapragasam ,Anthony P West Jr ,Michael S Seaman ,Pamela J Bjorkman

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design

通过一种新型两步机制持续诱导广谱中和HIV抗体,为免疫原设计提供指导

Skelly, Ashwin N; Gristick, Harry B; Li, Hui; Gavor, Edem; Connell, Andrew J; Kreider, Edward F; Marchitto, Lorie; Hogarty, Michael P; Newby, Maddy L; Allen, Joel D; Liu, Weimin; West, Anthony P Jr; Ayyanathan, Kasirajan; Campion, Mary S; Winters, Kaitlyn; Gordon, Colette G; Osbaldeston, Rebecca A; Akeley, Macy J; Li, Yingying; Singh, Ajay; Cruickshank, Kendra; Park, Younghoon; Zhao, Chengyan; Li, Xuduo; Amereh, Khaled; Itallie, Elizabeth Van; Carey, John W; Albertus, Amie; DeLaitsch, Andrew T; Keeffe, Jennifer R; Lituchy, Melinda G; Walsh, Agnes A; Morris, Daniel J; Habib, Rumi; Bibollet-Ruche, Frederic; Mishra, Nitesh; Avillion, Gabriel; Koranda, Nicholas S; Plante, Samantha J; Martella, Christian L; Lora, Jinery; Wang, Eric J D; Lewis, Mark G; Martin, Malcolm A; Nussenzweig, Michel C; Seaman, Michael S; Irvine, Darrell J; Wiehe, Kevin J; Haynes, Barton F; Wagh, Kshitij; Korber, Bette T; Andrabi, Raiees; Crispin, Max; Weissman, Drew; Bjorkman, Pamela J; Hahn, Beatrice H; Shaw, George M

Profiling a large HIV-1 elite neutralizer cohort reveals remarkable CD4bs bNAb for HIV-1 prevention and therapy

对大量 HIV-1 精英中和抗体队列进行分析,揭示了用于 HIV-1 预防和治疗的显著 CD4 结合位点广谱中和抗体 (bNAb)。

Gieselmann, Lutz; DeLaitsch, Andrew T; Rohde, Malena; Gruell, Henning; Kreer, Christoph; Ercanoglu, Meryem Seda; Gristick, Harry B; Schommers, Philipp; Ahmadov, Elvin; Radford, Caelan; Mazzolini, Andrea; Zhang, Lily; West, Anthony P Jr; Worczinski, Johanna; Momot, Anna; Reichwein, Maren L; Knüfer, Jacqueline; Stumpf, Ricarda; Mkhize, Nonhlanhla N; Kaldine, Haajira; Bhebhe, Sinethemba; Deshpande, Sharvari; Giovannoni, Frederico; Stefanutti, Erin; Benigni, Fabio; Havenar-Daughton, Colin; Corti, Davide; Kroidl, Arne; Adhikari, Anurag; Nanfack, Aubin J; Ambada, Georgia E; Duerr, Ralf; Maganga, Lucas; William, Wiston; Ntinginya, Nyanda E; Wolf, Timo; Geldmacher, Christof; Hoelscher, Michael; Lehmann, Clara; Moore, Penny L; Mora, Thierry; Walczak, Aleksandra M; Gilbert, Peter B; Doria-Rose, Nicole A; Huang, Yunda; Bloom, Jesse D; Seaman, Michael S; Bjorkman, Pamela J; Klein, Florian

Identification of a broad and potent V3 glycan site bNAb targeting an N332(gp120) glycan-independent epitope

鉴定出一种靶向N332(gp120)糖基非依赖性表位的广谱高效V3糖基化位点bNAb

Gieselmann, Lutz; DeLaitsch, Andrew T; Rohde, Malena; Radford, Caelan; Worczinski, Johanna; Momot, Anna; Ahmadov, Elvin; Burger, Judith A; Havenar-Daughton, Colin; Deshpande, Sharvari; Giovannoni, Federico; Corti, Davide; Kreer, Christoph; Ercanoglu, Meryem Seda; Schommers, Philipp; Georgiev, Ivelin S; West, Anthony P Jr; Knüfer, Jacqueline; Stumpf, Ricarda; Kroidl, Arne; Geldmacher, Christof; Maganga, Lucas; William, Wiston; Ntinginya, Nyanda E; Hoelscher, Michael; Yang, Zhengrong; Wei, Qing; Renfrow, Matthew; Green, Todd J; Novak, Jan; van Gils, Marit J; Gristick, Harry B; Gruell, Henning; Bloom, Jesse D; Seaman, Michael S; Bjorkman, Pamela J; Klein, Florian

Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes

设计和鉴定HIV-1候选疫苗,以诱导产生针对多个表位的抗体

Gristick, Harry B; Hartweger, Harald; Nishimura, Yoshiaki; Gavor, Edem; Nagashima, Kaito; Koranda, Nicholas S; Gnanapragasam, Priyanthi N P; Kakutani, Leesa M; Segovia, Luisa N; Donau, Olivia K; Keeffe, Jennifer R; West, Anthony P Jr; Martin, Malcolm A; Nussenzweig, Michel C; Bjorkman, Pamela J

Neutralizing antibodies elicited in macaques recognize V3 residues on altered conformations of HIV-1 Env trimer

猕猴体内产生的中和抗体可识别HIV-1 Env三聚体构象改变上的V3残基。

DeLaitsch, Andrew T; Keeffe, Jennifer R; Gristick, Harry B; Lee, Juliet A; Ding, Wenge; Liu, Weimin; Skelly, Ashwin N; Shaw, George M; Hahn, Beatrice H; Björkman, Pamela J

Short CDRL1 in intermediate VRC01-like mAbs is not sufficient to overcome key glycan barriers on HIV-1 Env

中等长度的VRC01样单克隆抗体中的短CDRL1不足以克服HIV-1 Env上的关键聚糖屏障。

Agrawal, Parul; Knudsen, Maria L; MacCamy, Anna; Hurlburt, Nicholas K; Khechaduri, Arineh; Salladay, Kelsey R; Kher, Gargi M; Kallur Siddaramaiah, Latha; Stuart, Andrew B; Bontjer, Ilja; Shen, Xiaoying; Montefiori, David; Gristick, Harry B; Bjorkman, Pamela J; Sanders, Rogier W; Pancera, Marie; Stamatatos, Leonidas

CD4 binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wild-type animals

CD4 结合位点免疫原在转基因和野生型动物中引发异源抗 HIV-1 中和抗体

Harry B Gristick, Harald Hartweger, Maximilian Loewe, Jelle van Schooten, Victor Ramos, Thiago Y Oliveira, Yoshiaki Nishimura, Nicholas S Koranda, Abigail Wall, Kai-Hui Yao, Daniel Poston, Anna Gazumyan, Marie Wiatr, Marcel Horning, Jennifer R Keeffe, Magnus A G Hoffmann, Zhi Yang, Morgan E Abernath