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Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis

利用阳离子载体持续向软骨内递送低剂量地塞米松治疗创伤后骨关节炎

Bajpayee, A G; De la Vega, R E; Scheu, M; Varady, N H; Yannatos, I A; Brown, L A; Krishnan, Y; Fitzsimons, T J; Bhattacharya, P; Frank, E H; Grodzinsky, A J; Porter, R M

关节炎

发表日期：2017

文献求助收藏

Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term

利用生物素蛋白纳米载体进行基于电荷的软骨内单剂量地塞米松递送，可长期抑制细胞因子诱导的分解代谢。

期刊:Osteoarthritis and Cartilage

影响因子:9

doi:10.1016/j.joca.2015.07.010

Bajpayee, A G; Quadir, M A; Hammond, P T; Grodzinsky, A J

Osteoarthritis year in review 2015: mechanics

2015年骨关节炎年度回顾：力学

期刊:Osteoarthritis and Cartilage

影响因子:9

doi:10.1016/j.joca.2015.08.018

Varady, N H; Grodzinsky, A J

关节炎

发表日期：2016

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Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology

体内和一种新型体外方法研究早期骨关节炎中空间组织丧失和细胞周围基质破坏的现象

期刊:Osteoarthritis and Cartilage

影响因子:9

doi:10.1016/j.joca.2016.02.001

Felka, T; Rothdiener, M; Bast, S; Uynuk-Ool, T; Zouhair, S; Ochs, B G; De Zwart, P; Stoeckle, U; Aicher, W K; Hart, M L; Shiozawa, T; Grodzinsky, A J; Schenke-Layland, K; Venkatesan, J K; Cucchiarini, M; Madry, H; Kurz, B; Rolauffs, B

Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: relevance to post-traumatic osteoarthritis

胰岛素样生长因子-1和地塞米松对细胞因子刺激的软骨的影响：与创伤后骨关节炎的相关性

期刊:Osteoarthritis and Cartilage

影响因子:9

doi:10.1016/j.joca.2014.11.006

Li, Y; Wang, Y; Chubinskaya, S; Schoeberl, B; Florine, E; Kopesky, P; Grodzinsky, A J

Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, tumor necrosis factor-α and interleukin-6, but accentuates degradation above a strain threshold

适度的动态压缩可抑制软骨对机械损伤、肿瘤坏死因子-α和白细胞介素-6的促分解代谢反应，但超过一定应变阈值则会加剧软骨的降解。

期刊:Osteoarthritis and Cartilage

影响因子:9

doi:10.1016/j.joca.2013.08.021

Li, Y; Frank, E H; Wang, Y; Chubinskaya, S; Huang, H-H; Grodzinsky, A J

Adult bone marrow stromal cell-based tissue-engineered aggrecan exhibits ultrastructure and nanomechanical properties superior to native cartilage

基于成人骨髓基质细胞的组织工程化聚集蛋白聚糖展现出优于天然软骨的超微结构和纳米力学性能。

期刊:Osteoarthritis and Cartilage

影响因子:9

doi:10.1016/j.joca.2010.07.015

Lee, H-Y; Kopesky, P W; Plaas, A; Sandy, J; Kisiday, J; Frisbie, D; Grodzinsky, A J; Ortiz, C

In-vivo time-dependent articular cartilage contact behavior of the tibiofemoral joint

胫股关节体内随时间变化的关节软骨接触行为

期刊:Osteoarthritis and Cartilage

影响因子:9

doi:10.1016/j.joca.2010.04.011

Hosseini, A; Van de Velde, S K; Kozanek, M; Gill, T J; Grodzinsky, A J; Rubash, H E; Li, G

发表日期：2010

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Nonuniformity in Periodontal Ligament: Mechanics and Matrix Composition

牙周韧带的不均匀性：力学和基质组成

Dexamethasone: chondroprotective corticosteroid or catabolic killer?

地塞米松：软骨保护性皮质类固醇还是分解代谢杀手？

Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis

利用阳离子载体持续向软骨内递送低剂量地塞米松治疗创伤后骨关节炎

Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term

利用生物素蛋白纳米载体进行基于电荷的软骨内单剂量地塞米松递送，可长期抑制细胞因子诱导的分解代谢。

Osteoarthritis year in review 2015: mechanics

2015年骨关节炎年度回顾：力学

Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology

体内和一种新型体外方法研究早期骨关节炎中空间组织丧失和细胞周围基质破坏的现象

Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: relevance to post-traumatic osteoarthritis

胰岛素样生长因子-1和地塞米松对细胞因子刺激的软骨的影响：与创伤后骨关节炎的相关性

Moderate dynamic compression inhibits pro-catabolic response of cartilage to mechanical injury, tumor necrosis factor-α and interleukin-6, but accentuates degradation above a strain threshold

适度的动态压缩可抑制软骨对机械损伤、肿瘤坏死因子-α和白细胞介素-6的促分解代谢反应，但超过一定应变阈值则会加剧软骨的降解。

Adult bone marrow stromal cell-based tissue-engineered aggrecan exhibits ultrastructure and nanomechanical properties superior to native cartilage

基于成人骨髓基质细胞的组织工程化聚集蛋白聚糖展现出优于天然软骨的超微结构和纳米力学性能。

In-vivo time-dependent articular cartilage contact behavior of the tibiofemoral joint

胫股关节体内随时间变化的关节软骨接触行为