Groettrup相关文献与解析，生知库 | 链接生命科学的每一步

Vilaprisan for the treatment of symptomatic endometriosis: results from a terminated phase 2b randomized controlled trial

Vilaprisan治疗症状性子宫内膜异位症：一项已终止的2b期随机对照试验的结果

doi:10.1016/j.xfre.2024.03.002

Taylor, Hugh S; Dong, Liying; Haikonen, Johanna; Oppelt, Peter; Tamussino, Karl; Wenzl, Rene; Faustmann, Thomas; Groettrup-Wolfers, Esther; Ren, Xiaowei; Seitz, Christian

发表日期：2024

文献求助收藏

Co-inhibition of immunoproteasome subunits LMP2 and LMP7 enables prevention of transplant arteriosclerosis

免疫蛋白酶体亚基LMP2和LMP7的共同抑制可预防移植动脉硬化

期刊:Cardiovascular Research

影响因子:10.2

doi:10.1093/cvr/cvac181

Jun Li, Shaobo Hu, Henry W B Johnson, Christopher J Kirk, Peng Xian, Yanping Song, Yuan Li, Nan Liu, Marcus Groettrup, Michael Basler

免疫

发表日期：2023

文献求助收藏

Novel intranasal vaccine targeting SARS-CoV-2 receptor binding domain to mucosal microfold cells and adjuvanted with TLR3 agonist Riboxximâ¢ elicits strong antibody and T-cell responses in mice.

一种新型鼻内疫苗，靶向 SARS-CoV-2 受体结合域至粘膜微褶皱细胞，并佐以 TLR3 激动剂 Riboxxim™，可在小鼠体内引发强烈的抗体和 T 细胞反应

期刊:Scientific Reports

影响因子:3.9

doi:10.1038/s41598-023-31198-3

Horvath Dennis, Temperton Nigel, Mayora-Neto Martin, Da Costa Kelly, Cantoni Diego, Horlacher Reinhold, GÃ¼nther Armin, Brosig Alexander, Morath Jenny, Jakobs Barbara, Groettrup Marcus, Hoschuetzky Heinz, Rohayem Jacques, Ter Meulen Jan

细胞生物学

发表日期：2023

文献求助收藏

Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis

AKR1C3抑制剂BAY1128688的肝毒性：一项早期终止的IIa期治疗子宫内膜异位症试验的结果

期刊:Drugs in Research & Development

影响因子:2.1

doi:10.1007/s40268-023-00427-5

Hilpert, Jan; Groettrup-Wolfers, Esther; Kosturski, Hristiyan; Bennett, Laura; Barnes, Catriona L K; Gude, Kerstin; Gashaw, Isabella; Reif, Stefanie; Steger-Hartmann, Thomas; Scheerans, Christian; Solms, Alexander; Rottmann, Antje; Mao, Guangping; Chapron, Charles

毒理研究

发表日期：2023

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Immunoproteasome Inhibition Reduces the T Helper 2 Response in Mouse Models of Allergic Airway Inflammation

免疫蛋白酶体抑制可降低过敏性气道炎症小鼠模型中的T辅助细胞2反应

期刊:Frontiers in Immunology

影响因子:5.9

doi:10.3389/fimmu.2022.870720

Oliveri, Franziska; Basler, Michael; Rao, Tata Nageswara; Fehling, Hans Joerg; Groettrup, Marcus

炎症

炎症/感染

Immunology/Inflammation

PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy

携带TLR3/RIG-I配体Riboxxim的PLGA颗粒疫苗与免疫检查点阻断剂协同作用，可有效发挥抗癌免疫疗法的作用。

期刊:Nature Communications

影响因子:14.7

doi:10.1038/s41467-021-23244-3

Julia Koerner # ，Dennis Horvath # ，Valerie L Herrmann ，Anna MacKerracher ，Bruno Gander ，Hideo Yagita ，Jacques Rohayem ，Marcus Groettrup

Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy

Parkin 是泛素样修饰物 FAT10 的 E3 连接酶，可抑制 Parkin 活化和线粒体自噬

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2021.108857

Nicola D Roverato, Carolin Sailer, Nicola Catone, Annette Aichem, Florian Stengel, Marcus Groettrup

On the Role of the Immunoproteasome in Protein Homeostasis

免疫蛋白酶体在蛋白质稳态中的作用

期刊:Cells

影响因子:5.2

doi:10.3390/cells10113216

Basler, Michael; Groettrup, Marcus

Competitive Metabolite Profiling of Natural Products Reveals Subunit Specific Inhibitors of the 20S Proteasome

天然产物的竞争性代谢物分析揭示了20S蛋白酶体的亚基特异性抑制剂

期刊:ACS Central Science

影响因子:10.4

doi:10.1021/acscentsci.9b01170

Pawar, Atul; Basler, Michael; Goebel, Heike; Alvarez Salinas, Gerardo Omar; Groettrup, Marcus; Böttcher, Thomas

代谢

发表日期：2020

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Safety and efficacy of vilaprisan in Japanese women with fibroids: The Phase 3 ASTEROID 8 trial

维拉普利生治疗日本子宫肌瘤女性患者的安全性和有效性：3期ASTEROID 8试验

Vilaprisan for the treatment of symptomatic endometriosis: results from a terminated phase 2b randomized controlled trial

Vilaprisan治疗症状性子宫内膜异位症：一项已终止的2b期随机对照试验的结果

Co-inhibition of immunoproteasome subunits LMP2 and LMP7 enables prevention of transplant arteriosclerosis

免疫蛋白酶体亚基LMP2和LMP7的共同抑制可预防移植动脉硬化

Novel intranasal vaccine targeting SARS-CoV-2 receptor binding domain to mucosal microfold cells and adjuvanted with TLR3 agonist Riboxximâ¢ elicits strong antibody and T-cell responses in mice.

一种新型鼻内疫苗，靶向 SARS-CoV-2 受体结合域至粘膜微褶皱细胞，并佐以 TLR3 激动剂 Riboxxim™，可在小鼠体内引发强烈的抗体和 T 细胞反应

Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis

AKR1C3抑制剂BAY1128688的肝毒性：一项早期终止的IIa期治疗子宫内膜异位症试验的结果

Immunoproteasome Inhibition Reduces the T Helper 2 Response in Mouse Models of Allergic Airway Inflammation

免疫蛋白酶体抑制可降低过敏性气道炎症小鼠模型中的T辅助细胞2反应

PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy

携带TLR3/RIG-I配体Riboxxim的PLGA颗粒疫苗与免疫检查点阻断剂协同作用，可有效发挥抗癌免疫疗法的作用。

Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy

Parkin 是泛素样修饰物 FAT10 的 E3 连接酶，可抑制 Parkin 活化和线粒体自噬

On the Role of the Immunoproteasome in Protein Homeostasis

免疫蛋白酶体在蛋白质稳态中的作用

Competitive Metabolite Profiling of Natural Products Reveals Subunit Specific Inhibitors of the 20S Proteasome

天然产物的竞争性代谢物分析揭示了20S蛋白酶体的亚基特异性抑制剂

Safety and efficacy of vilaprisan in Japanese women with fibroids: The Phase 3 ASTEROID 8 trial

维拉普利生治疗日本子宫肌瘤女性患者的安全性和有效性：3期ASTEROID 8试验

Vilaprisan for the treatment of symptomatic endometriosis: results from a terminated phase 2b randomized controlled trial

Vilaprisan治疗症状性子宫内膜异位症：一项已终止的2b期随机对照试验的结果

Co-inhibition of immunoproteasome subunits LMP2 and LMP7 enables prevention of transplant arteriosclerosis

免疫蛋白酶体亚基LMP2和LMP7的共同抑制可预防移植动脉硬化

Novel intranasal vaccine targeting SARS-CoV-2 receptor binding domain to mucosal microfold cells and adjuvanted with TLR3 agonist Riboxximâ¢ elicits strong antibody and T-cell responses in mice.

一种新型鼻内疫苗，靶向 SARS-CoV-2 受体结合域至粘膜微褶皱细胞，并佐以 TLR3 激动剂 Riboxxim™，可在小鼠体内引发强烈的抗体和 T 细胞反应

Hepatotoxicity of AKR1C3 Inhibitor BAY1128688: Findings from an Early Terminated Phase IIa Trial for the Treatment of Endometriosis

AKR1C3抑制剂BAY1128688的肝毒性：一项早期终止的IIa期治疗子宫内膜异位症试验的结果

Immunoproteasome Inhibition Reduces the T Helper 2 Response in Mouse Models of Allergic Airway Inflammation

免疫蛋白酶体抑制可降低过敏性气道炎症小鼠模型中的T辅助细胞2反应

PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy

携带TLR3/RIG-I配体Riboxxim的PLGA颗粒疫苗与免疫检查点阻断剂协同作用，可有效发挥抗癌免疫疗法的作用。

Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy

Parkin 是泛素样修饰物 FAT10 的 E3 连接酶，可抑制 Parkin 活化和线粒体自噬

On the Role of the Immunoproteasome in Protein Homeostasis

免疫蛋白酶体在蛋白质稳态中的作用

Competitive Metabolite Profiling of Natural Products Reveals Subunit Specific Inhibitors of the 20S Proteasome

天然产物的竞争性代谢物分析揭示了20S蛋白酶体的亚基特异性抑制剂

Novel intranasal vaccine targeting SARS-CoV-2 receptor binding domain to mucosal microfold cells and adjuvanted with TLR3 agonist Riboxximâ¢ elicits strong antibody and T-cell responses in mice.