日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

VX-809 corrects folding defects in cystic fibrosis transmembrane conductance regulator protein through action on membrane-spanning domain 1

VX-809 通过作用于跨膜结构域 1 来纠正囊性纤维化跨膜传导调节蛋白的折叠缺陷

Ren, Hong Yu; Grove, Diane E; De La Rosa, Oxana; Houck, Scott A; Sopha, Pattarawut; Van Goor, Fredrick; Hoffman, Beth J; Cyr, Douglas M

The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508

内质网相关 Hsp40 DNAJB12 和 Hsc70 协同作用,促进新生 CFTRDeltaF508 的 RMA1 E3 依赖性降解。

Grove, Diane E; Fan, Chun-Yang; Ren, Hong Yu; Cyr, Douglas M

Analysis of CFTR folding and degradation in transiently transfected cells.

对瞬时转染细胞中 CFTR 折叠和降解的分析

Grove Diane E, Rosser Meredith F N, Watkins Richard L, Cyr Douglas M

Mechanisms for rescue of correctable folding defects in CFTRDelta F508

CFTRDelta F508 中可纠正折叠缺陷的修复机制

Grove, Diane E; Rosser, Meredith F N; Ren, Hong Yu; Naren, Anjaparavanda P; Cyr, Douglas M

The Use of Small Molecules to Correct Defects in CFTR Folding, Maturation, and Channel Activity

利用小分子纠正CFTR折叠、成熟和通道活性缺陷

Rosser, Meredith F N; Grove, Diane E; Cyr, Douglas M

Assembly and misassembly of cystic fibrosis transmembrane conductance regulator: folding defects caused by deletion of F508 occur before and after the calnexin-dependent association of membrane spanning domain (MSD) 1 and MSD2.

囊性纤维化跨膜电导调节因子的组装和错误组装:F508 缺失引起的折叠缺陷发生在钙网蛋白依赖的跨膜结构域 (MSD) 1 和 MSD2 结合之前和之后

Rosser Meredith F N, Grove Diane E, Chen Liling, Cyr Douglas M