Groves Jay T相关文献与解析，生知库 | 链接生命科学的每一步

Conditional requirement for dimerization of the membrane-binding module for BTK signaling in lymphocyte cell lines.

淋巴细胞系中 BTK 信号传导对膜结合模块二聚化的条件性要求

期刊:Science Signaling

影响因子:6.6

doi:10.1126/scisignal.ado1252

Eisen Timothy J, Ghaffari-Kashani Sam, Hung Chien-Lun, Groves Jay T, Weiss Arthur, Kuriyan John

细胞生物学

发表日期：2025

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Autophosphorylation of oncoprotein TEL-ABL in myeloid and lymphoid cells confers resistance to the allosteric ABL inhibitor asciminib.

髓系和淋巴系细胞中癌蛋白 TEL-ABL 的自身磷酸化赋予了对变构 ABL 抑制剂 asciminib 的耐药性

期刊:Science Signaling

影响因子:6.6

doi:10.1126/scisignal.adt5931

Muratcioglu Serena, Eide Christopher A, Hung Chien-Lun, Gorday Kent, Sumpena Emily, Zuo Wenqi, Groves Jay T, Druker Brian J, Kuriyan John

Kinetic Proofreading through Parallel Reactions on a Single T Cell Receptor

通过单个T细胞受体上的平行反应进行动力学校正

期刊:

影响因子:

doi:10.1101/2025.06.01.657268

Morita, Shumpei; Groves, Jay T

A unifying model of LAT condensates in reconstitution experiments

重组实验中LAT凝聚物的统一模型

期刊:

影响因子:

doi:10.1101/2025.10.31.685772

Omar, Yannick A D; Sun, Simou; Kardar, Mehran; Groves, Jay T; Chakraborty, Arup K

LAT

发表日期：2025

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T cell costimulatory and inhibitory signals di4erentially modulate LAT condensate nucleation propensity after TCR ligation

T细胞共刺激和抑制信号差异性地调节TCR交联后LAT凝聚体成核倾向

期刊:

影响因子:

doi:10.1101/2025.11.01.685673

Choi, Saehyun; Kim, Sungi; Tijham, Jessica; Eisen, Timothy; Morita, Shumpei; O'Dair, Mark K; Groves, Jay T

Differential roles of kinetic on- and off-rates in T-cell receptor signal integration revealed with a modified Fab'-DNA ligand

利用修饰的Fab'-DNA配体揭示T细胞受体信号整合中动力学结合速率和解离速率的不同作用

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2406680121

Wilhelm, Kiera B; Vissa, Anand; Groves, Jay T

Positive feedback in Ras activation by full-length SOS arises from autoinhibition release mechanism

全长SOS对Ras激活的正反馈源于自身抑制解除机制

期刊:Biophysical Journal

影响因子:3.1

doi:10.1016/j.bpj.2024.07.014

Ren, He; Lee, Albert A; Lew, L J Nugent; DeGrandchamp, Joseph B; Groves, Jay T

发表日期：2024

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BTK autoinhibition analyzed by high-throughput swaps of SH2 domains

通过高通量SH2结构域交换分析BTK自身抑制

Parallel reactions on a single T cell receptor offer a robust kinetic proofreading mechanism

单个T细胞受体上的平行反应提供了一种强大的动力学校正机制

Proofreading and single-molecule sensitivity in T cell receptor signaling by condensate nucleation.

通过凝聚成核作用实现T细胞受体信号传导中的校对和单分子敏感性

Conditional requirement for dimerization of the membrane-binding module for BTK signaling in lymphocyte cell lines.

淋巴细胞系中 BTK 信号传导对膜结合模块二聚化的条件性要求

Autophosphorylation of oncoprotein TEL-ABL in myeloid and lymphoid cells confers resistance to the allosteric ABL inhibitor asciminib.

髓系和淋巴系细胞中癌蛋白 TEL-ABL 的自身磷酸化赋予了对变构 ABL 抑制剂 asciminib 的耐药性

Kinetic Proofreading through Parallel Reactions on a Single T Cell Receptor

通过单个T细胞受体上的平行反应进行动力学校正

A unifying model of LAT condensates in reconstitution experiments

重组实验中LAT凝聚物的统一模型

T cell costimulatory and inhibitory signals di4erentially modulate LAT condensate nucleation propensity after TCR ligation

T细胞共刺激和抑制信号差异性地调节TCR交联后LAT凝聚体成核倾向

Differential roles of kinetic on- and off-rates in T-cell receptor signal integration revealed with a modified Fab'-DNA ligand

利用修饰的Fab'-DNA配体揭示T细胞受体信号整合中动力学结合速率和解离速率的不同作用

Positive feedback in Ras activation by full-length SOS arises from autoinhibition release mechanism

全长SOS对Ras激活的正反馈源于自身抑制解除机制