文献库，生知库 | 链接生命科学的每一步

日期影响因子

A novel 2-oxopyrrolidine derivative (LN-53) efficiently induces Nrf-2 signaling pathway activation in human epidermal keratinocytes.

一种新型的 2-氧代吡咯烷衍生物（LN-53）能有效诱导人表皮角质形成细胞中 Nrf-2 信号通路的激活。

期刊:Pharmacological Reports

影响因子:3.8

doi:10.1007/s43440-025-00757-y

Sarac Basak Ezgi, Nissim Laura, Karaguzel Dilara, Arik Gokhan, Kahremany Shirin, Korshin Edward E, Gruzman Arie, Karaaslan Cagatay

细胞生物学

发表日期：2025

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NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis

NRF2 在皮肤疾病中的作用：药理学激活可保护皮肤免受光损伤和光敏性皮炎的侵害

期刊:Free Radical Biology and Medicine

影响因子:8.2

doi:10.1016/j.freeradbiomed.2022.06.238

Kahremany, Shirin; Hofmann, Lukas; Gruzman, Arie; Dinkova-Kostova, Albena T; Cohen, Guy

发表日期：2022

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Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy

合理改变手性氟化和氘代依米司他衍生物的药代动力学以用于视网膜治疗

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.1c00279

Blum, Eliav; Zhang, Jianye; Zaluski, Jordan; Einstein, David E; Korshin, Edward E; Kubas, Adam; Gruzman, Arie; Tochtrop, Gregory P; Kiser, Philip D; Palczewski, Krzysztof

发表日期：2021

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Multifunctionality of prostatic acid phosphatase in prostate cancer pathogenesis

前列腺酸性磷酸酶在前列腺癌发病机制中的多功能性

期刊:Bioscience Reports

影响因子:4.7

doi:10.1042/BSR20211646

Alpert, Evgenia; Akhavan, Armin; Gruzman, Arie; Hansen, William J; Lehrer-Graiwer, Joshua; Hall, Steven C; Johansen, Eric; McAllister, Sean; Gulati, Mittul; Lin, Ming-Fong; Lingappa, Vishwanath R

发表日期：2021

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A Potent Leukocyte Transmigration Blocker: GT-73 Showed a Protective Effect against LPS-Induced ARDS in Mice

一种强效的白细胞跨内皮迁移阻滞剂：GT-73 对 LPS 诱导的小鼠 ARDS 显示出保护作用

期刊:Molecules

影响因子:4.6

doi:10.3390/molecules26154583

Blum, Eliav; Margalit, Raanan; Levy, Laura; Getter, Tamar; Lahav, Ron; Zilber, Sofia; Bradfield, Paul; Imhof, Beat A; Alpert, Evgenia; Gruzman, Arie

细胞生物学

发表日期：2021

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SH-29 and SK-119 Attenuates Air-Pollution Induced Damage by Activating Nrf2 in HaCaT Cells

SH-29 和 SK-119 通过激活 HaCaT 细胞中的 Nrf2 来减轻空气污染引起的损伤

期刊:International Journal of Environmental Research and Public Health

doi:10.3390/ijerph182312371

Kahremany, Shirin; Hofmann, Lukas; Eretz-Kdosha, Noy; Silberstein, Eldad; Gruzman, Arie; Cohen, Guy

细胞生物学

发表日期：2021

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Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch

对瘙痒性瘙痒初始步骤理解的进展：瘙痒是如何触发的

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms21144883

Kahremany, Shirin; Hofmann, Lukas; Gruzman, Arie; Cohen, Guy

发表日期：2020

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Development of chiral fluorinated alkyl derivatives of emixustat as drug candidates for the treatment of retinal degenerative diseases

开发手性氟化烷基衍生物 emixustat 作为治疗视网膜退行性疾病的候选药物

期刊:Bioorganic & Medicinal Chemistry Letters

影响因子:2.2

doi:10.1016/j.bmcl.2020.127421

Blum, Eliav; Zhang, Jianye; Korshin, Edward; Palczewski, Krzysztof; Gruzman, Arie

发表日期：2020

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Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions

神经连接蛋白-2衍生的肽包覆的聚酰胺胺（PAMAM）树状聚合物可增强胰岛β细胞的增殖和功能

期刊:Medchemcomm

doi:10.1039/c8md00419f

Munder, Anna; Moskovitz, Yoni; Meir, Aviv; Kahremany, Shirin; Levy, Laura; Kolitz-Domb, Michal; Cohen, Guy; Shtriker, Efrat; Viskind, Olga; Lellouche, Jean-Paul; Senderowitz, Hanoch; Chessler, Steven D; Korshin, Edward E; Ruthstein, Sharon; Gruzman, Arie

细胞生物学

发表日期：2019

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An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist

CMF-019 的简便合成：(S)-5-甲基-3-{1-(戊-3-基)-2-(噻吩-2-基甲基)-1H-苯并[d]咪唑-5-甲酰胺基}己酸，一种强效的 Apelin 受体 (APJ) 激动剂

期刊:Medicinal Chemistry

影响因子:2.6

doi:10.2174/1573406414666180412154952

Trifonov, Lena; Afri, Michal; Palczewski, Krzysztof; Korshin, Edward E; Gruzman, Arie

发表日期：2018

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