日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A Rationally Designed Novel Bifunctional Human TNF-α- and Janus Kinase-Targeted soloMER Drug Conjugate (SDC) with a Neutrophil Elastase Cleavable Linker Delivering Inflammation Site-Specific Release of Payload

一种合理设计的新型双功能人TNF-α和Janus激酶靶向soloMER药物偶联物（SDC），带有中性粒细胞弹性蛋白酶可切割的连接子，可实现有效载荷在炎症部位的特异性释放。

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.6c00532
Murray, Euan; Priyanka, Stella; Martinez-Fraile, Julia; Grygorash, Ruslan; Idress, Mohannad; Brownbridge, Luke C; Glavina, Stella; Camper, Nicolas; Boyd, Robert; Porter, Andrew J; Barelle, Caroline J; Ubah, Obinna C
信号转导
中性粒细胞
炎症/感染
Immunology/Inflammation
TNF-α
Human
细胞生物学
炎症
粒细胞
发表日期：2026
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Incorporation of Hydrophilic Macrocycles Into Drug-Linker Reagents Produces Antibody-Drug Conjugates With Enhanced in vivo Performance

将亲水性大环化合物引入药物连接剂中，可制备出体内性能增强的抗体-药物偶联物。

期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2022.764540
Evans, Nick; Grygorash, Ruslan; Williams, Paul; Kyle, Andrew; Kantner, Terrence; Pathak, Ravindra; Sheng, XiaoBo; Simoes, Fabio; Makwana, Hiteshri; Resende, Ricardo; de Juan, Elena; Jenkins, Alan; Morris, David; Michelet, Aurelie; Jewitt, Frances; Rudge, Felicity; Camper, Nicolas; Manin, Anaïs; McDowell, William; Pabst, Martin; Godwin, Antony; Frigerio, Mark; Bird, Matthew
发表日期：2022
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