日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain.

Nicastrin 的作用是空间位阻,从而阻碍底物跨膜结构域驱动的 β-分泌酶-底物相互作用

Bolduc David M, Montagna Daniel R, Gu Yongli, Selkoe Dennis J, Wolfe Michael S

Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones

第三部分:不影响Notch通路γ-分泌酶的抑制剂:2-取代氨基吡啶并嘧啶酮的构效关系研究

Zhang, Jing; Lu, Dai; Wei, Han-Xun; Gu, Yongli; Selkoe, Dennis J; Wolfe, Michael S; Augelli-Szafran, Corinne E

Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs

第一部分:不影响Notch通路γ-分泌酶的抑制剂:新型萘基和苯并呋喃基酰胺类似物的鉴定

Lu, Dai; Wei, Han-Xun; Zhang, Jing; Gu, Yongli; Osenkowski, Pamela; Ye, Wenjuan; Selkoe, Dennis J; Wolfe, Michael S; Augelli-Szafran, Corinne E

Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols

第二部分:不影响Notch通路的γ-分泌酶抑制剂:新型γ-氨基萘醇的研究

Wei, Han-Xun; Lu, Dai; Sun, Vivien; Zhang, Jing; Gu, Yongli; Osenkowski, Pamela; Ye, Wenjuan; Selkoe, Dennis J; Wolfe, Michael S; Augelli-Szafran, Corinne E

Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein

γ-分泌酶调控的定量分析可以区分抑制剂化合物对两种底物(Notch 和淀粉样前体蛋白)的选择性。

Yang, Ting; Arslanova, Dilyara; Gu, Yongli; Augelli-Szafran, Corinne; Xia, Weiming