日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Multiomics identifies a cholesterol-TFEB-PLD3-TLR9 axis driving immunosuppressive tumor-associated macrophage polarization in esophageal squamous cell carcinoma

多组学分析发现，胆固醇-TFEB-PLD3-TLR9轴驱动食管鳞状细胞癌中免疫抑制性肿瘤相关巨噬细胞的极化。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2520427123
Tan, Licheng; Zhou, Hongyu; Zhang, Baifeng; Kwong, Dora Lai Wan; Jia, Yongxu; Huang, Jiayi; Siu, Kin To Hugo; Zhang, Shuang; Huang, Jiao; Luo, Jie; Yang, Yuma; Liu, Qin; Lyu, Yingchen; Ban, Liuxian; Qi, Ziyang; Yu, Nanzhou; He, Chaohui; Zhang, Weiguang; Qin, Yanru; Liu, Beilei; Guan, Xinyuan
代谢
免疫/内分泌
细胞生物学
TLR9
巨噬细胞
巨噬细胞
TFEB
肿瘤
肿瘤免疫
发表日期：2026
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Virus-human chromatin interactions reorganise 3D genome and hijack KDM5B for promoting metastasis in nasopharyngeal carcinoma.

病毒与人类染色质相互作用重组 3D 基因组并劫持 KDM5B 以促进鼻咽癌转移

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-61597-1
Chung Dittman Lai-Shun, Hou Zhaozheng, Wang Ying, Islam Kazi Anisha, Liu Songran, Liu Jiayan, Chow Larry Ka-Yue, Wong Yuki Yuk-Wun, Chak Cyrus Paak-Ting, Zhang Yingpei, Gong Lanqi, Qi Ziyang, Cheng Kiu-Wai, Yu Zhuoyou, Feng Ping, Huang Zilu, Ngan Roger Kai-Cheong, Guan Xinyuan, Ng Wai-Tong, Liu Zhonghua, Tsang Anna Chi-Man, Kwong Dora Lai-Wan, Lee Anne Wing-Mui, Lee Victor Ho-Fun, Chen Honglin, Xia Yunfei, Dai Wei
肿瘤
Human
肿瘤免疫
发表日期：2025
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SNORA58 Facilitates Radioresistance via Suppressing JNK1-Mediated Ferroptosis in Esophageal Squamous Cell Carcinoma.

SNORA58 通过抑制 JNK1 介导的食管鳞状细胞癌铁死亡来促进放射抗性。

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202508515
Zheng Yinli, Liu Fangyi, Huang Yuhua, Feng Yanfen, Yang Xia, Wu Jinjun, Yang Xin, Lin Xuanhao, Jiang Lives, Zeng Tingting, Li Yan, Guan Xinyuan, Wang Yuanyuan, Chen Chunyan, Yun Jingping
细胞生物学
JNK
NK1
铁死亡
发表日期：2025
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C1q(+) Macrophage-Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma.

C1q(+)巨噬细胞-肿瘤细胞相互作用通过GPR17/PI3K/AKT通路诱导鼻咽癌DNA高甲基化促进肿瘤发生

期刊:Advanced Science
影响因子:14.1
doi:10.1002/advs.202503434
Liu Yunzhi, Huang Cuicui, Luo Min, Lu Wenfu, Zhang Baifeng, Bai Lu, Zheng Shuyue, Tan Yanan, Li Shanshan, Wang Huali, Gong Lanqi, Guan Xinyuan
细胞生物学
肿瘤
PI3K/Akt
巨噬细胞
发表日期：2025
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Regulatory factor X1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by transcriptional regulation of BECN1.

调控因子 X1 通过转录调控 BECN1 促进索拉非尼诱导的肝细胞癌铁死亡

期刊:Cellular Oncology
影响因子:4.8
doi:10.1007/s13402-024-01017-6
Yang Zhiwen, Yuan Yichuan, Niu Yi, Zuo Dinglan, Liu Wenwu, Li Kai, Shi Yunxing, Qiu Zhiyu, Li Keren, Lin Zhu, Zhong Chengrui, Huang Zhenkun, He Wei, Guan Xinyuan, Yuan Yunfei, Zeng Weian, Qiu Jiliang, Li Binkui
细胞生物学
转录调控
铁死亡
发表日期：2025
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S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos

S100A10 通过细胞外囊泡转运并调节其蛋白质载荷来促进肝细胞癌的发生发展。

期刊:Gut
影响因子:25.8
doi:10.1136/gutjnl-2022-327998
Wang, Xia; Huang, Hongyang; Sze, Karen Man-Fong; Wang, Jin; Tian, Lu; Lu, Jingyi; Tsui, Yu-Man; Ma, Hoi Tang; Lee, Eva; Chen, Ao; Lee, Joyce; Wang, Ying; Yam, Judy Wai Ping; Cheung, Tan-To; Guan, Xinyuan; Ng, Irene Oi-Lin
囊泡
细胞生物学
肿瘤
肿瘤免疫
发表日期：2023
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3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor-on-a-Chip

用于体外重建肿瘤微环境的3D仿生模型：球状体、类器官和芯片肿瘤

期刊:Advanced Healthcare Materials
影响因子:9.6
doi:10.1002/adhm.202202609
Li, Wenxiu; Zhou, Zhihang; Zhou, Xiaoyu; Khoo, Bee Luan; Gunawan, Renardi; Chin, Y Rebecca; Zhang, Liang; Yi, Changqing; Guan, Xinyuan; Yang, Mengsu
3D/类器官
肿瘤
肿瘤微环境
肿瘤免疫
发表日期：2023
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Author Correction: Isoliquiritigenin modulates miR-374a/PTEN/Akt axis to suppress breast cancer tumorigenesis and metastasis

作者更正：异甘草素通过调节 miR-374a/PTEN/Akt 轴抑制乳腺癌的肿瘤发生和转移

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-023-36401-z
Peng, Fu; Tang, Hailin; Liu, Peng; Shen, Jiangang; Guan, Xinyuan; Xie, Xiaofang; Gao, Jihai; Xiong, Liang; Jia, Lei; Chen, Jianping; Peng, Cheng
肿瘤免疫
乳腺癌
PTEN
肿瘤
发表日期：2023
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Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors

重塑系统性肿瘤免疫环境（STIE）和肿瘤免疫微环境（TIME）以增强实体瘤免疫疗法的疗效

期刊:Journal of Hematology & Oncology
影响因子:40.4
doi:10.1186/s13045-022-01307-2
Xu, Liangliang; Zou, Chang; Zhang, Shanshan; Chu, Timothy Shun Man; Zhang, Yan; Chen, Weiwei; Zhao, Caining; Yang, Li; Xu, Zhiyuan; Dong, Shaowei; Yu, Hao; Li, Bo; Guan, Xinyuan; Hou, Yuzhu; Kong, Feng-Ming
肿瘤
肿瘤免疫
TIM
免疫/内分泌
发表日期：2022
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G3BP2 regulated by the lncRNA LINC01554 facilitates esophageal squamous cell carcinoma metastasis through stabilizing HDGF transcript

lncRNA LINC01554调控的G3BP2通过稳定HDGF转录本促进食管鳞状细胞癌转移。

期刊:Oncogene
影响因子:7.3
doi:10.1038/s41388-021-02073-0
Zheng, Yinli; Wu, Jinjun; Deng, Ru; Lin, Censhan; Huang, Yuhua; Yang, Xia; Wang, Chunhua; Yang, Mingming; He, Yangfan; Lu, Jiabin; Su, Xiaodong; Yan, Qian; Zhu, Yinghui; Guan, Xinyuan; Li, Yan; Yun, Jingping
肿瘤
肿瘤免疫
信号转导
G3BP2
3BP2
lncRNA
HDGF
细胞生物学
发表日期：2022
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