日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Correction: SIRT2 Ablation Has No Effect on Tubulin Acetylation in Brain, Cholesterol Biosynthesis or the Progression of Huntington's Disease Phenotypes In Vivo.

更正:SIRT2 消融对脑内微管蛋白乙酰化、胆固醇生物合成或亨廷顿病表型的进展没有影响

Bobrowska Anna, Donmez Gizem, Weiss Andreas, Guarente Leonard, Bates Gillian

Nicotinamide riboside with pterostilbene (NRPT) increases NAD(+) in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI

烟酰胺核苷与紫檀芪 (NRPT) 可提高急性肾损伤 (AKI) 患者的 NAD(+) 水平:一项随机、双盲、安慰剂对照、逐步递增剂量 NRPT 治疗 AKI 患者的安全性研究

Simic, Petra; Vela Parada, Xavier Fernando; Parikh, Samir M; Dellinger, Ryan; Guarente, Leonard P; Rhee, Eugene P

Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer's disease

脑老化速度和APOE ε4是阿尔茨海默病的协同危险因素

Glorioso, Christin A; Pfenning, Andreas R; Lee, Sam S; Bennett, David A; Sibille, Etienne L; Kellis, Manolis; Guarente, Leonard P

DEP domain-containing mTOR-interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease

含有DEP结构域的mTOR相互作用蛋白抑制脂肪生成,并改善酒精性肝病中的肝脂肪变性和急性加重型慢性肝损伤

Chen, Hanqing; Shen, Feng; Sherban, Alex; Nocon, Allison; Li, Yu; Wang, Hua; Xu, Ming-Jiang; Rui, Xianliang; Han, Jinyan; Jiang, Bingbing; Lee, Donghwan; Li, Na; Keyhani-Nejad, Farnaz; Fan, Jian-Gao; Liu, Feng; Kamat, Amrita; Musi, Nicolas; Guarente, Leonard; Pacher, Pal; Gao, Bin; Zang, Mengwei

SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis.

SIRT1 去乙酰化酶在衰老引起的神经肌肉退行性变和肌萎缩侧索硬化症中的作用

Herskovits Adrianna Z, Hunter Tegan A, Maxwell Nicholas, Pereira Katherine, Whittaker Charles A, Valdez Gregorio, Guarente Leonard P

Mutations that Allow SIR2 Orthologs to Function in a NAD(+)-Depleted Environment

使SIR2同源蛋白能够在NAD(+)耗竭环境中发挥功能的突变

Ondracek, Caitlin R; Frappier, Vincent; Ringel, Alison E; Wolberger, Cynthia; Guarente, Leonard

SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2

SIRT1是成骨细胞主转录因子RUNX2的正调控因子。

Zainabadi, Kayvan; Liu, Cassie J; Guarente, Leonard

SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis

SIRT1是体内骨量的正向调节因子,也是骨质疏松症的治疗靶点。

Zainabadi, Kayvan; Liu, Cassie J; Caldwell, Alison L M; Guarente, Leonard

It takes two to tango: NAD(+) and sirtuins in aging/longevity control

跳探戈需要两个人:NAD(+) 和 sirtuins 在衰老/长寿控制中的作用

Imai, Shin-Ichiro; Guarente, Leonard

Correction: Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

更正:Sirt1通过抑制胰岛β细胞中的UCP2来调节胰岛素分泌

Bordone, Laura; Motta, Maria Carla; Picard, Frederic; Robinson, Ashley; Jhala, Ulupi S; Apfeld, Javier; McDonagh, Thomas; Lemieux, Madeleine; McBurney, Michael; Szilvasi, Akos; Easlon, Erin J; Lin, Su-Ju; Guarente, Leonard