Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.
共存的基因组改变定义了 KRAS 突变肺腺癌的主要亚型，这些亚型具有不同的生物学特性、免疫特征和治疗脆弱性
期刊:Cancer Discovery
影响因子:33.3
doi:10.1158/2159-8290.CD-14-1236
Skoulidis Ferdinandos, Byers Lauren A, Diao Lixia, Papadimitrakopoulou Vassiliki A, Tong Pan, Izzo Julie, Behrens Carmen, Kadara Humam, Parra Edwin R, Canales Jaime Rodriguez, Zhang Jianjun, Giri Uma, Gudikote Jayanthi, Cortez Maria A, Yang Chao, Fan Youhong, Peyton Michael, Girard Luc, Coombes Kevin R, Toniatti Carlo, Heffernan Timothy P, Choi Murim, Frampton Garrett M, Miller Vincent, Weinstein John N, Herbst Roy S, Wong Kwok-Kin, Zhang Jianhua, Sharma Padmanee, Mills Gordon B, Hong Waun K, Minna John D, Allison James P, Futreal Andrew, Wang Jing, Wistuba Ignacio I, Heymach John V
