日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

DNA damage response profile distinguishes poor-acting gliomas with shared methylome signatures

DNA损伤反应谱可区分具有共同甲基化组特征的不良预后胶质瘤

Leelatian, Nalin; Singh, Charu; Bouffard, Richard; Sundaram, Ranjini K; Diggins, Kirsten E; Sullivan, William; Paradkar, Sateja; Omay, Zeynep Erson; Mobley, Bret C; Gueble, Susan E; Vasquez, Juan C; Bindra, Ranjit S

Targeted CRISPR knockout screening identifies known and novel chemogenomic interactions between DNA damaging agents and DNA repair genes

靶向 CRISPR 基因敲除筛选可识别 DNA 损伤剂与 DNA 修复基因之间已知的和新的化学基因组学相互作用

Heer, Collin D; Elia, James L; Menon, Vijay; Johnson, Spenser S; Arbelaez, Sofia R; Friedman, Sam; Lopez-Giraldez, Francesc; Sundaram, Ranjini K; Herzon, Seth B; Bindra, Ranjit S; Gueble, Susan E

The novel DNA cross-linking agent KL-50 is active against patient-derived models of new and recurrent post-temozolomide mismatch repair-deficient glioblastoma.

新型 DNA 交联剂 KL-50 对替莫唑胺治疗后新发和复发性错配修复缺陷型胶质母细胞瘤的患者来源模型具有活性

McCord Matthew, Sears Thomas, Wang Wenxia, Chaliparambil Rahul, An Shejuan, Sarkaria Jann, James C David, Ruggeri Bruce, Gueble Susan, Bindra Ranjit, Horbinski Craig

DNA repair helicases: from mechanistic understanding to therapeutic implications

DNA修复解旋酶:从机制理解到治疗意义

Menon, Vijay; Gueble, Susan E

Development of Syngeneic Murine Glioma Models with Somatic Mismatch Repair Deficiency to Study Therapeutic Responses to Alkylating Agents and Immunotherapy.

建立具有体细胞错配修复缺陷的同基因小鼠胶质瘤模型,以研究烷化剂和免疫疗法的治疗反应

Bhatt Deepti, Sundaram Ranjini K, López Karla S Lugo, Lee Teresa, Gueble Susan E, Vasquez Juan C

Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers

KL-50(一种用于治疗耐药性脑癌的候选咪唑并四嗪类药物)的作用机制

Huseman, Eric D; Lo, Anna; Fedorova, Olga; Elia, James L; Gueble, Susan E; Lin, Kingson; Sundaram, Ranjini K; Oh, Joonseok; Liu, Jinchan; Menges, Fabian; Rees, Matthew G; Ronan, Melissa M; Roth, Jennifer A; Batista, Victor S; Crawford, Jason M; Pyle, Anna M; Bindra, Ranjit S; Herzon, Seth B

Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51

西地尼布通过下调 BRCA1/2 和 RAD51 来抑制同源定向 DNA 修复

Alanna R Kaplan, Susan E Gueble, Yanfeng Liu, Sebastian Oeck, Hoon Kim, Zhong Yun, Peter M Glazer