Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro.
XLF 和 XRCC4 无序区域的多价相互作用促进了强大的细胞 NHEJ，并驱动了体外连接增强凝聚体的形成
期刊:Nature Structural & Molecular Biology
影响因子:10.1
doi:10.1038/s41594-024-01339-x
Vu Duc-Duy, Bonucci Alessio, Brenière Manon, Cisneros-Aguirre Metztli, Pelupessy Philippe, Wang Ziqing, Carlier Ludovic, Bouvignies Guillaume, Cortes Patricia, Aggarwal Aneel K, Blackledge Martin, Gueroui Zoher, Belle Valérie, Stark Jeremy M, Modesti Mauro, Ferrage Fabien
