In vivo CRISPR screening identifies NF1/RASA1/TP53 co-mutations and downstream MEK signaling as a common key mechanism of sinonasal tumorigenesis
体内CRISPR筛选发现NF1/RASA1/TP53共突变和下游MEK信号通路是鼻窦肿瘤发生的常见关键机制
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影响因子:
doi:10.1101/2025.05.19.654661
Vu, Kenny; Gunti, Sreenivasulu; Viswanathan, Ramya; Nandal, Anjali; Larkin, Riley; Cho, Sungwoo; Zou, Jonathan; Ramolia, Shivani; Hoke, Austin T K; Barbosa, Siani M; Gallia, Gary L; Rooper, Lisa M; Floudas, Charalampos S; Cheng, Hui; Miller, Christine N; Guest, Mary R; Notaro, Marco; Raziuddin, Arati; Sun, Zhonghe; Wu, Xiaolin; Faraji, Farhoud; Lechner, Matt; Comoglio, Federico; Edmondson, Elijah F; Chari, Raj; London, Nyall R Jr
