日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators

获得的靶向改变导致对 p53-Y220C 激活剂的临床耐药性

Fece de la Cruz, Ferran; Varkaris, Andreas; Patel, Parasvi S; Kushner, Elijah W; Morales-Giron, Alvin A; Lee, Sangmi Sandra; Singh, Ankit; Kim, Clara T; Norden, Bryanna L; Ehnstrom, Sara; Riedl, Jakob M; Curtis, Jacquelyn M; Barnes, Haley; Kehlmann, Allison M; Chevalier, Nicholas J; Okuma, Hitomi S; Patel, Manisha; Wirth, Lori J; Connell, Brendan; Nugent, Francis; Pappas, Leontios; Lau, Kayao; Juric, Dejan; Hopkins, Jessica L; Guiley, Keelan Z; Shokat, Kevan M; Gulhan, Doga C; Parikh, Aparna R; Corcoran, Ryan B

Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket

通过保守的隐蔽口袋靶向 Ras、Rho 和 Rab 家族 GTPase

Johannes Morstein, Victoria Bowcut, Micah Fernando, Yue Yang, Lawrence Zhu, Meredith L Jenkins, John T Evans, Keelan Z Guiley, D Matthew Peacock, Sophie Krahnke, Zhi Lin, Katrine A Taran, Benjamin J Huang, Andrew G Stephen, John E Burke, Felice C Lightstone, Kevan M Shokat

Strain-release alkylation of Asp12 enables mutant selective targeting of K-Ras-G12D

Asp12 的应变释放烷基化可实现对 K-Ras-G12D 突变体的选择性靶向

Qinheng Zheng #,Ziyang Zhang #,Keelan Z Guiley,Kevan M Shokat

A foundational atlas of autism protein interactions reveals molecular convergence

自闭症蛋白质相互作用基础图谱揭示分子趋同性

Wang, Belinda; Vartak, Rasika; Zaltsman, Yefim; Naing, Zun Zar Chi; Hennick, Kelsey M; Polacco, Benjamin J; Bashir, Ali; Eckhardt, Manon; Bouhaddou, Mehdi; Xu, Jiewei; Sun, Nawei; Lasser, Micaela C; Zhou, Yuan; McKetney, Justin; Guiley, Keelan Z; Chan, Una; Kaye, Julia A; Chadha, Nishant; Cakir, Merve; Gordon, Martin; Khare, Prachi; Drake, Sam; Drury, Vanessa; Burke, David F; Gonzalez, Silvano; Alkhairy, Sahar; Thomas, Reuben; Lam, Stephanie; Morris, Montana; Bader, Ethel; Seyler, Meghan; Baum, Tierney; Krasnoff, Rebecca; Wang, Sheng; Pham, Presley; Arbalaez, Juan; Pratt, Dexter; Chag, Shivali; Mahmood, Nadir; Rolland, Thomas; Bourgeron, Thomas; Finkbeiner, Steven; Swaney, Danielle L; Bandyopadhay, Sourav; Ideker, Trey; Beltrao, Pedro; Willsey, Helen Rankin; Obernier, Kirsten; Nowakowski, Tomasz J; Hüttenhain, Ruth; State, Matthew W; Willsey, A Jeremy; Krogan, Nevan J

A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability

小分子与 p53 体细胞突变体 Y220C 发生反应,挽救野生型热稳定性

Keelan Z Guiley, Kevan M Shokat

Nanomolar Protein Thermal Profiling with Modified Cyanine Dyes

利用修饰的花菁染料进行纳摩尔级蛋白质热分析

Malakoutikhah, Morteza; Mahran, Randa; Gooran, Negin; Masoumi, Ahmadreza; Lundell, Katri; Liljeblad, Arto; Guiley, Keelan; Dai, Shizhong; Zheng, Qinheng; Zhu, Lawrence; Shokat, Kevan M; Kopra, Kari; Härmä, Harri

The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes

MuvB 复合物结合并稳定细胞周期依赖性基因转录起始位点下游的核小体

Anushweta Asthana, Parameshwaran Ramanan, Alexander Hirschi, Keelan Z Guiley, Tilini U Wijeratne, Robert Shelansky, Michael J Doody, Haritha Narasimhan, Hinrich Boeger, Sarvind Tripathi, Gerd A Müller, Seth M Rubin

Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S)

获得性丝氨酸的化学酰化抑制K-Ras(G12S)的致癌信号传导

Ziyang Zhang,Keelan Z Guiley,Kevan M Shokat

Cyclin-dependent kinase-mediated phosphorylation and the negative regulatory domain of transcription factor B-Myb modulate its DNA binding

细胞周期蛋白依赖性激酶介导的磷酸化和转录因子B-Myb的负调控域调节其DNA结合

Tilini U Wijeratne, Keelan Z Guiley, Hsiau-Wei Lee, Gerd A Müller, Seth M Rubin

p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition

p27 变构激活细胞周期蛋白依赖性激酶 4 并拮抗 palbociclib 抑制

Keelan Z Guiley, Jack W Stevenson, Kevin Lou, Krister J Barkovich, Vishnu Kumarasamy, Tilini U Wijeratne, Katharine L Bunch, Sarvind Tripathi, Erik S Knudsen, Agnieszka K Witkiewicz, Kevan M Shokat, Seth M Rubin