日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis

GLP-1R/GcgR 双激动剂 Cotadutide 通过调节线粒体功能和脂肪生成来缓解 NASH 和肝纤维化

Michelle L Boland #, Rhianna C Laker #, Karly Mather, Arkadiusz Nawrocki, Stephanie Oldham, Brandon B Boland, Hilary Lewis, James Conway, Jacqueline Naylor, Silvia Guionaud, Michael Feigh, Sanne S Veidal, Louise Lantier, Owen P McGuinness, Joseph Grimsby, Cristina M Rondinone, Lutz Jermutus, Martin

Innovations, challenges, and minimal information for standardization of humanized mice

人源化小鼠标准化方面的创新、挑战和信息匮乏

Stripecke, Renata; Münz, Christian; Schuringa, Jan Jacob; Bissig, Karl-Dimiter; Soper, Brian; Meeham, Terrence; Yao, Li-Chin; Di Santo, James P; Brehm, Michael; Rodriguez, Estefania; Wege, Anja Kathrin; Bonnet, Dominique; Guionaud, Silvia; Howard, Kristina E; Kitchen, Scott; Klein, Florian; Saeb-Parsy, Kourosh; Sam, Johannes; Sharma, Amar Deep; Trumpp, Andreas; Trusolino, Livio; Bult, Carol; Shultz, Leonard

Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction

非酒精性脂肪性肝炎的严重程度定义为线粒体功能障碍导致的代偿性抗氧化能力丧失

Michelle L Boland, Stephanie Oldham, Brandon B Boland, Sarah Will, Jean-Martin Lapointe, Silvia Guionaud, Christopher J Rhodes, James L Trevaskis

Superior reductions in hepatic steatosis and fibrosis with co-administration of a glucagon-like peptide-1 receptor agonist and obeticholic acid in mice

在小鼠中联合使用胰高血糖素样肽-1 受体激动剂和奥贝胆酸可显著减少肝脏脂肪变性和纤维化

Hani Jouihan, Sarah Will, Silvia Guionaud, Michelle L Boland, Stephanie Oldham, Peter Ravn, Anthony Celeste, James L Trevaskis

Inhibition of T-cell activation by the CTLA4-Fc Abatacept is sufficient to ameliorate proteinuric kidney disease

CTLA4-Fc 阿巴西普抑制 T 细胞活化足以改善蛋白尿性肾病

Marcela Herrera, Magnus Söderberg, Alan Sabirsh, Barbara Valastro, Johan Mölne, Beatriz Santamaria, Angela M Valverde, Silvia Guionaud, Stephanie Heasman, Alison Bigley, Lutz Jermutus, Cristina Rondinone, Matthew Coghlan, David Baker, Carol Moreno Quinn