日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Maraviroc attenuates orbital remodeling, inflammation, and lipid dysregulation in a murine model of thyroid eye disease associated with Graves' disease.

在与格雷夫斯病相关的甲状腺眼病小鼠模型中，马拉维罗克可减轻眼眶重塑、炎症和脂质失调。

期刊:Frontiers in Endocrinology
影响因子:4.6
doi:10.3389/fendo.2026.1717212
Hashemi Arani Fahimeh, Gulbins Anne, Horstmann Mareike, Nolte Insa, Daser Anke, Bechrakis Nikolaos E, Banga J Paul, Gulbins Erich, Eckstein Anja, Görtz Gina-Eva
炎症/感染
Immunology/Inflammation
炎症
发表日期：2026
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Rhinovirus infection promotes suppression of sphingosine and enhanced bacterial infection in cystic fibrosis airways

鼻病毒感染会抑制鞘氨醇的产生，并加剧囊性纤维化气道中的细菌感染。

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2026.111381
Wilson, Gregory C; Keitsch, Simone; Wilker, Barbara; Soddemann, Matthias; Kamler, Markus; Gulbins, Erich
微生物学
炎症/感染
发表日期：2026
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Immune activation and response dynamics of human iPSC-derived macrophages in tuberculosis infection models.

结核病感染模型中人iPSC衍生巨噬细胞的免疫激活和反应动态。

期刊:Clinical & Translational Immunology
影响因子:3.8
doi:10.1002/cti2.70071
Paasch Daniela, Schevel Hannah, Riehle Andrea, Costa Bibiana, Toufaili Hassan, Gehnen Tabea, Dahlmann Julia, Pavlou Andreas, Neehus Anna-Lena, Nguyen Ariane Hai Ha, Schiering Erika, Buchegger Theresa, Bustamante Jacinta, Hansen Gesine, Kalinke Ulrich, Gulbins Erich, Grassmé Heike, Lachmann Nico
巨噬细胞
细胞生物学
炎症/感染
巨噬细胞
免疫/内分泌
发表日期：2026
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Zuclopenthixol inhibits residual activity of acid sphingomyelinase in Niemann pick disease type B: a case report with in vitro validation

佐克洛喷噻醇抑制尼曼匹克病B型患者酸性鞘磷脂酶的残余活性：一例病例报告及体外验证

期刊:Orphanet Journal of Rare Diseases
影响因子:3.5
doi:10.1186/s13023-026-04238-0
Schiller, Maximilian; Steiner, Katharina Marie; Bonnet, Udo; Gulbins, Erich; Scherbaum, Norbert
发表日期：2026
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Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment strategy for schizophrenia

酸性鞘磷脂酶活性提示了一种治疗精神分裂症的新型抗精神病药物治疗策略

期刊:Molecular Psychiatry
影响因子:10.1
doi:10.1038/s41380-025-02893-6
Chestnykh, Daria; Mühle, Christiane; Schumacher, Fabian; Kalinichenko, Liubov S; Löber, Stefan; Gmeiner, Peter; Alzheimer, Christian; von Hörsten, Stephan; Kleuser, Burkhard; Uebe, Steffen; Ekici, Arif B; Gulbins, Erich; Kornhuber, Johannes; Jin, Hee Kyung; Bae, Jae-Sung; Lourdusamy, Anbarasu; Müller, Christian P
精神分裂症
神经科学
发表日期：2025
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Selective inhibition of mitochondrial Kv1.3 prevents and alleviates multiple sclerosis in vivo

选择性抑制线粒体Kv1.3可预防和缓解体内多发性硬化症。

期刊:EMBO Molecular Medicine
影响因子:9
doi:10.1038/s44321-025-00307-2
Beatrice Angi # ，Tatiana Varanita # ，Marco Puthenparampil ，Valentina Scattolini ，Michael Donadon ，Mitra Tavakoli ，Marta Favero ，Maguie El Boustani ，Matthias Soddemann ，Lucia Biasutto ，Diletta Arcidiacono ，Alberto Ongaro ，Andrea Mattarei ，Livio Trentin ，Gregory Wilson ，Erich Gulbins ，Paolo Gallo ，Ildiko Szabo
信号转导
多发性硬化症
线粒体
发表日期：2025
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Amitriptyline potently neutralizes distinct SARS-CoV-2 variants including D614G, Omicron BA.5, and Omicron XBB.1

阿米替林能有效中和多种SARS-CoV-2变异株，包括D614G、Omicron BA.5和Omicron XBB.1。

期刊:Frontiers in Microbiology
影响因子:4.5
doi:10.3389/fmicb.2025.1631947
Zydek, Isabel; Thümmler, Laura; Beckmann, Nadine; Sehl, Carolin; Soddemann, Matthias; Grüneberg, Rabea; Elsner, Carina; Kamler, Markus; Dittmer, Ulf; Witzke, Oliver; Kadow, Stephanie; Gulbins, Erich; Becker, Katrin Anne; Krawczyk, Adalbert
SARS-CoV-2
发表日期：2025
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Sphingosine kills Mycobacteria and suppresses mycobacterial lung infections

鞘氨醇能杀死分枝杆菌并抑制分枝杆菌肺部感染。

期刊:Journal of Molecular Medicine-Jmm
影响因子:4.2
doi:10.1007/s00109-025-02534-z
Wu, Yuqing; Schnitker, Fabian; Liu, Yongjie; Keitsch, Simone; Caicci, Federico; Schumacher, Fabian; Riehle, Andrea; Pollmeier, Barbara; Kehrmann, Jan; Kleuser, Burkhard; Kamler, Markus; Szabo, Ildiko; Grassmé, Heike; Gulbins, Erich
炎症/感染
发表日期：2025
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Sphingosine-mediated death of Pseudomonas aeruginosa involves degradation of cardiolipin by the maintenance of outer lipid asymmetry system.

鞘氨醇介导的铜绿假单胞菌死亡涉及通过维持外部脂质不对称系统降解心磷脂

期刊:Infection and Immunity
影响因子:2.8
doi:10.1128/iai.00591-24
Grassmé Heike, Wilson Gregory C, Wu Yuqing, Hasenberg Mike, Keitsch Simone, Caicci Federico, Edwards Michael J, Szabo Ildiko, Gulbins Erich
心血管
发表日期：2025
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Acid sphingomyelinase inhibition induces cerebral angiogenesis post-ischemia/reperfusion in an oxidative stress-dependent way and promotes endothelial survival by regulating mitochondrial metabolism

酸性鞘磷脂酶抑制剂以氧化应激依赖的方式诱导缺血/再灌注后脑血管生成，并通过调节线粒体代谢促进内皮细胞存活。

期刊:Cell Death & Disease
影响因子:8.1
doi:10.1038/s41419-024-06935-9
Ayan Mohamud Yusuf # ,Mina Borbor # ,Tanja Hussner # ,Carolin Weghs ,Britta Kaltwasser ,Matthias Pillath-Eilers ,Bernd Walkenfort ,Richard Kolesnick ,Erich Gulbins ,Dirk M Hermann # ,Ulf Brockmeier #
代谢
毒理研究
血管生成
氧化应激
细胞生物学
线粒体
神经科学
内皮细胞
发表日期：2024
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